Test Price
2,800 AED✅ Home Collection Available
DHA-APPROVED GENOMICS · ISO 9001:2015
CALM1 Gene Catecholaminergic Polymorphic Ventricular Tachycardia Type 4 (CPVT4) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity – ISO 15189–accredited NGS processing with clinical-grade variant calling across the full CALM1 coding region.
- VIP Mobile Phlebotomy – Temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM; hospital-grade specimen handling.
- Clinical Guidance – Complimentary telephonic post-test clinical correlation session with our medical genetics team.
- Insurance Support – Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The CALM1 gene encodes calmodulin, a critical calcium-signaling protein expressed in cardiac myocytes. Pathogenic variants in CALM1 disrupt calcium handling and cause catecholaminergic polymorphic ventricular tachycardia type 4 (CPVT4), a potentially lethal inherited arrhythmia syndrome. Our next-generation sequencing assay interrogates the entire coding region, all exon-intron boundaries, and flanking regulatory elements of CALM1, providing definitive molecular risk stratification for at-risk individuals and families.
| Feature | Our Test (NGS) | Sanger Sequencing Alternative |
|---|---|---|
| Method | Next-Generation Sequencing (HiSeq) | Capillary electrophoresis (single amplicon) |
| Analytical Sensitivity | >99.9% for SNVs and small indels | ~99% (limited to predefined region) |
| Turnaround Time | 3–4 Weeks | 5–7 business days (incomplete coverage) |
| Clinical Utility | Full gene plus adjacent regions, ACMG/AMP classification | Known familial variant only |
Physician Insight & Safety Protocols
“As a consultant in medical genetics, I emphasise that genetic testing for CPVT4 through CALM1 analysis provides definitive variant identification when present, yet the result must always be integrated with the full clinical phenotype, family pedigree, and electrocardiographic findings. A negative sequencing result does not exclude the diagnosis, and any variant of uncertain significance requires multidisciplinary review before being used to guide clinical management.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Advisory on Cardiac Therapy
Genetic results from this assay must never serve as the sole basis for altering prescribed cardiac therapy. All decisions regarding antiarrhythmic medications, beta-blockers, or implantable cardioverter-defibrillator therapy must be made by your treating cardiologist in conjunction with the complete genetic report and clinical assessment. Never self-adjust or discontinue prescribed medications.
Exclusion Criteria & Emergency Red Flags
- Individuals who have undergone allogeneic bone marrow transplant within the last six months (donor DNA interference may compromise results).
- Patients in active hemodynamic instability or ongoing cardiac arrest.
- Inability to provide informed consent (legal guardian must authorise for minors).
- Emergency warning: If you experience syncope, chest pain, or sustained palpitations, seek immediate emergency medical attention; do not wait for genetic test results before seeking care.
Patient FAQ & Clinical Guidance
1. Why do I need this genetic test if I already have a clinical diagnosis?
The CALM1 NGS test identifies the exact pathogenic variant underlying your catecholaminergic polymorphic ventricular tachycardia, enabling precision risk stratification and family cascade screening. Knowing the specific variant allows your cardiologist to tailor therapy and provides relatives with the option of predictive testing.
2. Is the sample collection painful, and how should I prepare?
Our VIP mobile phlebotomist uses a single venipuncture for whole blood collection; discomfort is minimal and transient. No fasting, medication adjustment, or special preparation is required. Collection is performed in your home environment under strict cold-chain conditions.
3. What happens after the result is reported?
You will receive a comprehensive ACMG-classified report detailing any identified variant, its pathogenicity classification, and clinical implications. A complimentary telephonic post-test clinical correlation session is provided to help you and your cardiologist integrate the findings into your management plan.
4. Can this test detect all types of CPVT?
This assay is specific to CALM1, which accounts for CPVT type 4. Other forms of CPVT are associated with different genes (RYR2, CASQ2, TRDN, etc.). If clinical suspicion remains high after a negative CALM1 result, your geneticist may recommend a broader arrhythmia panel.
UAE Regulatory & Data Privacy Adherence
Data Protection & Legal Framework
All genetic data generated by this assay is handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE maintains ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and holds DHA Facility License Number 1143, ensuring all genomic testing meets the highest standards of quality, confidentiality, and regulatory compliance within the UAE healthcare framework.
Clinical & Logistical Metadata
| Test Name | CALM1 Gene Sequencing – Catecholaminergic Polymorphic Ventricular Tachycardia Type 4 (CPVT4) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) or Buccal Swab / FTA Card – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina HiSeq platform – full coding region, exon-intron boundaries, and flanking regulatory elements of CALM1 |
| ICD-10-CM Code | I47.2 |
| LOINC Code | 81313-8 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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