Test Price
2,800 AED✅ Home Collection Available
CALCRL Gene Genetic Test – Hereditary Vascular System Defects | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Test Overview & Methodology
The CALCRL Gene Genetic Test is a high-resolution next-generation sequencing assay designed to detect pathogenic variants in the CALCRL gene linked to hereditary vascular system defects. This test analyzes the full coding region of the CALCRL gene to identify mutations that may compromise vascular integrity, endothelial function, and circulatory homeostasis. Identification of these variants enables early clinical surveillance, informed family planning, and targeted therapeutic intervention.
| Feature | Our Test – CALCRL NGS | Closest Alternative – Sanger Sequencing |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity – Full gene coverage | ~95% – Targeted exon analysis only |
| Methodology | NGS (Next Generation Sequencing) – LC-MS/MS validated | Capillary Electrophoresis Sanger |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Sample Types | Whole Blood / Extracted DNA / FTA Card (One Drop) | Whole Blood Only |
| Accreditation | ISO 9001:2015 (INT/EGQ/2509DA/3139) | DHA Licensed: 1143 | Variable – May lack UAE-specific accreditation |
Physician Insight & Safety Protocols
"The CALCRL gene encodes the calcitonin receptor-like receptor, a critical mediator of vascular endothelial function. Pathogenic variants in this gene can predispose to significant vascular malformations that may remain clinically silent until a catastrophic event occurs. As a consultant medical geneticist, I emphasize that this NGS-based test delivers comprehensive coverage of the gene, but results must be interpreted within a detailed three-generation pedigree and correlated with clinical imaging findings. Genetic counseling before and after testing is essential to ensure patients understand the implications for themselves and their at-risk relatives."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Advisory
Genetic test results provide one component of a comprehensive clinical evaluation. Do not discontinue prescribed medications, alter your treatment regimen, or make lifestyle changes solely based on genetic findings. All results must be correlated with clinical history, imaging studies, and physical examination by your treating physician before any therapeutic decision is made. Always consult your doctor before making any changes to your healthcare plan.
Safety Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Inability to provide informed consent for genetic testing.
- Unavailability of a three-generation family pedigree for accurate variant classification.
- Active severe systemic illness or hemodynamic instability that may compromise sample integrity.
- Recent allogeneic blood transfusion (within 14 days) if using whole blood sample.
Seek Immediate Emergency Care If
- Sudden, severe chest pain or tearing sensation suggestive of vascular rupture.
- Acute limb ischemia – sudden pallor, pain, and loss of pulse in extremities.
- Sudden severe headache with loss of consciousness – possible vascular event.
- Acute uncontrolled bleeding or spontaneous large hematoma formation.
These symptoms require emergency medical intervention, not elective genetic testing.
Patient FAQ & Clinical Guidance
1. What is the CALCRL gene test and who should consider it?
The CALCRL gene test uses next-generation sequencing to identify pathogenic mutations in the CALCRL gene that are directly linked to hereditary vascular system defects affecting circulatory integrity. This test is clinically indicated for individuals with a personal or family history of unexplained vascular malformations, early-onset vascular events, or a known familial predisposition to vascular disorders. It is also appropriate for asymptomatic adult family members of a proband with a confirmed CALCRL pathogenic variant.
2. How is the sample collected and what is the expected turnaround time?
Sample collection is performed via a minimally invasive blood draw using a standard EDTA whole blood tube, a single drop on an FTA card, or previously extracted DNA (minimum 1 µg). Our VIP Mobile Phlebotomy service visits your home daily between 8 AM and 11 PM. All samples are transported under ISO-certified temperature-controlled cold-chain conditions (2–8°C) to our DHA-licensed laboratory. Results are delivered within 3 to 4 weeks from sample receipt, accompanied by a comprehensive clinical report.
3. What will my results tell me and how will they be interpreted?
Your results will classify any identified CALCRL variants as pathogenic, likely pathogenic, benign, or of uncertain significance according to ACMG/AMP guidelines. This genetic risk profile for vascular system defects must be correlated with your clinical history by a qualified physician. Every test includes post-test telephonic clinical guidance with a DHA-licensed clinician who explains the findings, discusses implications for at-risk family members, and recommends appropriate follow-up care or specialist referrals to medical genetics, cardiology, or vascular surgery as indicated.
4. What preparation is needed before the test and are there any restrictions?
No specific medication or supplement avoidance is required prior to sample collection for this genetic test. You should continue all prescribed medications unless otherwise directed by your treating physician. A mandatory pre-test genetic counseling session is required to draw a comprehensive three-generation pedigree and document clinical history, including prior vascular events, imaging studies, and family history of circulatory disorders. No fasting is necessary.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, de-identified, and stored on secured servers with access limited to authorized clinical personnel only. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring that every patient provides written informed consent specifically for genetic analysis and data handling prior to sample collection. DHA Facility License: 1143. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | CALCRL Gene Genetic Test – Hereditary Vascular System Defects |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA (≥1 µg), FTA Card (One Drop) |
| Methodology Used | Next Generation Sequencing (NGS) – Full Coding Region Analysis |
| ICD-10-CM Code | Q27.8 |
| LOINC Code | 21665-7 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians