Test Price
2,800 AED✅ Home Collection Available
BRAF Gene LEOPARD Syndrome Type 3 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
This next-generation sequencing (NGS) test targets the full coding region of the BRAF gene to detect germline mutations associated with LEOPARD syndrome type 3. Delivering 99.9% diagnostic sensitivity, the service is processed in our ISO 9001:2015 certified laboratory (Cert: INT/EGQ/2509DA/3139). Clinical logistics include VIP mobile phlebotomy & temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM, plus telephonic post-test clinical guidance. Direct insurance verification is available via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced NGS panel analyzes the entire coding region of the BRAF gene to detect germline mutations causing LEOPARD syndrome type 3—a RASopathy characterized by multiple lentigines, cardiac defects, and short stature. Performed on DNA extracted from whole blood or FTA card, results are available in 14–21 working days (3–4 calendar weeks), enabling precise clinical management and familial risk stratification.
| Feature | Our Test (NGS Whole‑Gene) | Closest Alternative (Targeted Sanger) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (full BRAF coding region) | Sanger sequencing of selected exons |
| Diagnostic Yield | >99.9% for point mutations, small indels & copy‑number variants | <85% – may miss deep intronic / large rearrangements |
| Turnaround Time | 14–21 working days (3–4 weeks calendar) | 7–14 working days |
| Variant Classification | ACMG/AMP‑based; DHA‑endorsed bioinformatics pipeline | Limited manual curation |
Physician Insight & Safety Protocols
“As a DHA‑licensed consultant medical geneticist, I emphasize that BRAF gene sequencing for LEOPARD syndrome type 3 must be performed after thorough pre‑test genetic counselling and pedigree analysis. While the NGS technology offers high sensitivity, results require careful correlation with clinical findings and familial patterns. A negative result does not exclude the condition, and all findings should be discussed with a clinical geneticist before any medical decisions.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Safety Protocols
Safety Exclusion Criteria & Emergency Red Flags
- Not suitable for patients who have not completed a genetic counselling session with pedigree analysis.
- Cannot replace a comprehensive dysmorphology examination by a clinical geneticist.
- If the patient is under 18, documented parental/guardian consent and pre‑test counselling are mandatory in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Seek emergency care immediately if the patient develops sudden chest pain, fainting, palpitations, or severe shortness of breath—these may indicate cardiac involvement requiring urgent evaluation.
- Individuals with a known bleeding disorder or those unable to provide the required sample volume must consult the laboratory prior to collection.
Important Medication Advisory
⚠️ Do not discontinue prescribed medication without consulting your doctor. This test does not influence any ongoing therapy unless explicitly recommended by your clinician.
Patient FAQ & Clinical Guidance
1. What does the BRAF gene test for LEOPARD syndrome type 3 detect?
This NGS test identifies pathogenic variants in the BRAF gene that cause LEOPARD syndrome type 3, a rare inherited condition featuring multiple lentigines, ECG abnormalities, and pulmonary stenosis. It screens the entire coding sequence and exon‑intron boundaries, providing a definitive molecular diagnosis when clinical criteria are suggestive. Results guide targeted cardiac surveillance and family planning.
2. How should I prepare for the test, and what does the genetic counselling involve?
You must attend a pre‑test genetic counselling session to outline family history, draw a pedigree chart, and discuss possible outcomes. No fasting is required; the sample can be whole blood, extracted DNA, or a dried blood spot on an FTA card. The counselling session, which takes about 45–60 minutes, ensures informed consent and appropriate interpretation of results.
3. What is the turnaround time, and can children be tested?
Results are reported within 3 to 4 weeks, and yes, pediatric testing is routinely performed under Federal Decree‑Law No. 4 of 2016 on Medical Liability guidelines. A venous blood draw or finger‑prick FTA card collection is arranged by our VIP mobile phlebotomist for all age groups. Post‑test tele‑consultations with a specialist are included to explain the findings and recommend next steps.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: All laboratory processes adhere to Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. The facility is licensed by Dubai Health Authority (DHA License No. 1143). ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | BRAF Gene LEOPARD Syndrome Type 3 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 14–21 working days (3–4 calendar weeks) |
| Sample Type / Matrix | Whole blood (EDTA) or FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) – full coding region of BRAF |
| ICD-10-CM Code | Q87.89 |
| LOINC Code | 79679-8 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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