Test Price
2,800 AED✅ Home Collection Available
ARSB Gene Mucopolysaccharidosis Type 6 Genetic Test in UAE | 2,800 AED | DHA-Licensed NGS Diagnostics
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity – This test utilises next‑generation sequencing (NGS) full‑gene analysis of the ARSB locus, delivering single‑nucleotide resolution across the entire coding region. Processing is conducted in an ISO 9001:2015 accredited laboratory (Cert. INT/EGQ/2509DA/3139) with a validated mean coverage of 100×. Premium temperature‑controlled home collection is included with VIP mobile phlebotomy available daily from 8 AM to 11 PM. Each report is accompanied by a post‑test telephonic clinical consultation to explain variant pathogenicity and inheritance patterns. Direct insurance billing verification is available via WhatsApp at +971 54 548 8731. All services comply with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
The ARSB Gene Genetic Test screens for pathogenic variants in the arylsulfatase B gene, confirming Mucopolysaccharidosis Type 6 (Maroteaux‑Lamy syndrome). This high‑coverage next‑generation sequencing assay delivers definitive molecular diagnosis for metabolic disorder evaluation, identifying both known pathogenic mutations and novel variants across the entire ARSB coding region.
| Aspect | Our Test – NGS Full Gene Sequencing | Closest Alternative – Targeted Genotyping |
|---|---|---|
| Precision | Single‑nucleotide resolution across entire ARSB coding region | Limited to pre‑selected common mutations only |
| Method | Next‑Generation Sequencing (Illumina® platform) with 100× mean coverage | Sanger sequencing of selected exons or PCR‑based arrays |
| Speed | Results in 3–4 Weeks (from sample receipt) | 6–8 Weeks |
Physician Insight & Safety Protocols
Insight from Lina Osama Zaki Quteineh – Consultant Medical Genetics | DHA Registration ID: 9294403
Every MPS VI story is unique, and while NGS provides exceptionally powerful molecular resolution, results must always be correlated with enzymatic assays and the full clinical picture. Families searching for answers deserve a compassionate, thorough interpretation of each finding. Our team is committed to guiding you through every step, regardless of the outcome.
Clinical Advisory – Medication Continuity
Genetic test results inform long‑term disease management but must never prompt immediate alterations to current therapy. Do not discontinue or adjust any prescribed medication, enzyme replacement therapy, or supportive treatment without explicit direction from the treating physician. Always consult your specialist before making changes based on genetic findings.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Minors (under 18 years) must provide guardian consent per UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability; inability to produce guardianship documentation or refusal of mandatory pre‑test genetic counselling.
- Exclusion: Individuals unable to provide a venous blood sample, extracted DNA, or FTA card specimen (finger‑prick drop is acceptable under supervision).
- Red Flag: Acute neurological deterioration, severe respiratory distress, or sudden onset of pain – seek emergency medical care immediately. This test is intended for elective, planned diagnostic investigation, not for crisis intervention.
- Red Flag: Experience of intense psychological distress when considering genetic results – contact your genetic counsellor or call emergency services; our team provides immediate support pathways.
Patient FAQ & Clinical Guidance
1. What exactly does the ARSB NGS test detect, and how reliable is it for MPS VI diagnosis?
Answer: This test sequences the entire coding region of the ARSB gene with greater than 99.9% analytical sensitivity, identifying both known pathogenic mutations and novel variants that cause Mucopolysaccharidosis type 6. When combined with clinical evaluation and enzymatic correlation, it provides a definitive molecular confirmation that fulfils DHA and international diagnostic guidelines.
2. How is the sample collected and what preparation is required before the test?
Answer: A peripheral blood sample, extracted DNA, or a single drop of blood on an FTA card is collected by our VIP home phlebotomy team, which operates daily from 8 AM to 11 PM using a certified cold‑chain logistics system that preserves DNA integrity. No fasting is required. A mandatory pre‑test genetic counselling session to construct a detailed pedigree chart is required before testing.
3. How long until I receive results, and what does a positive finding mean for my family?
Answer: Results are reported within 3 to 4 weeks and are accompanied by a post‑test telephone consultation that explains variant pathogenicity and the autosomal recessive inheritance pattern. A positive ARSB mutation confirms MPS VI and enables carrier testing for family members, guiding reproductive options and early treatment planning.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance
All genetic data are processed in strict compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree‑Law No. 4 of 2016 on Medical Liability. No genetic information is shared with third parties without explicit written consent, and all laboratory records are encrypted and access‑controlled.
Clinical & Logistical Metadata
| Test Name | ARSB Gene Mucopolysaccharidosis Type 6 Genetic Test (NGS Full Gene Sequencing) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Blood, Extracted DNA, or FTA Card (Finger‑prick) |
| Methodology Used | Next‑Generation Sequencing (NGS) – Full Gene Sequencing |
| ICD-10-CM Code | E76.2 |
| LOINC Code | 94044-9 |
| DHA Facility License & Laboratory Address | DHA License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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