Test Price
2,800 AED✅ Home Collection Available
ALG8 Gene (Congenital Disorder of Glycosylation Type Ih) Genetic Test in UAE
Executive Summary & Core Metrics
- ✔ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited NGS Processing.
- ✔ Premium Logistics: Paid Hospital‑Grade Home Collection via ISO Certified Cold‑Chain Protocol.
- ✔ Clinical Guidance: Complimentary Telephonic Post‑Test Clinical Interpretation.
- ✔ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ALG8 NGS test is a comprehensive genetic analysis that identifies pathogenic variants in the ALG8 gene, responsible for Congenital Disorder of Glycosylation Type Ih (CDG‑1h), a rare metabolic condition impairing glycoprotein synthesis. This test provides a definitive diagnosis to guide personalised therapeutic strategies.
| Feature | Our Test (ALG8 NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% analytical sensitivity, full gene coverage | ~98% sensitivity, limited to exons only |
| Methodology | Illumina NovaSeq™ NGS with deep bioinformatics | Capillary electrophoresis, individual exon PCR |
| Turnaround | 3–4 Weeks | 2–3 Weeks (may miss deep intronic variants) |
Physician Insight & Safety Protocols
“Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA: 9294403) emphasises that ALG8 variants require careful correlation with clinical phenotype and biochemical transferrin isoelectric focusing. This test supports diagnosis but should never replace comprehensive clinical evaluation. Post‑test genetic counselling is essential for families, and treatment adjustments should always be guided by a specialist.”
Advisory Notice
Do not discontinue or modify any prescribed medication without direct consultation with your treating physician. Test results must be interpreted by a qualified geneticist.
Exclusion Criteria & Red Flags
- Exclusion: Active febrile illness, severe anaemia, or inability to lie flat for venipuncture.
- Red Flag: If the patient experiences acute metabolic decompensation (vomiting, lethargy, seizures, hypoglycaemia), seek Emergency Medical Care immediately — do not wait for test results.
- Pre‑test genetic counselling is mandatory to document a three‑generation pedigree.
Patient FAQ & Clinical Guidance
1. What does the ALG8 NGS test diagnose?
Snippet: The ALG8 NGS test identifies inherited mutations causing Congenital Disorder of Glycosylation Type Ih, a rare metabolic disorder affecting protein glycosylation and multi‑organ function. It confirms the genetic diagnosis and guides personalised care.
2. How is the sample collected, and is it painful?
Snippet: A standard venipuncture (2–3 mL of whole blood) or a painless finger‑prick FTA card is used. Topical anaesthetics are available for paediatric collection. The procedure is minimally invasive and quick.
3. What is the typical turnaround time for results?
Snippet: From sample receipt, the full NGS analysis and clinical report are completed within 3 to 4 weeks, inclusive of confirmatory Sanger validation when required. Results are delivered digitally and via a follow‑up consultation.
UAE Regulatory & Data Privacy Adherence
All genetic testing services strictly comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted, anonymised, and processed with explicit consent. Clinical safety and consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | ALG8 Gene (Congenital Disorder of Glycosylation Type Ih) NGS Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (Venipuncture or FTA Card) |
| Methodology Used | Illumina NovaSeq™ NGS with bioinformatics analysis |
| ICD-10-CM Code | E74.8, Z13.79, Z15.89 |
| LOINC Code | 96021-5 |
| DHA Facility License & Laboratory Address | DHA Facility License #1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Corporate Lab: DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians