Test Price
2,800 AED✅ Home Collection Available
AKT3 Gene Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Type 2 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
فحص تسلسل الجين AKT3 المرتبط بمتلازمة ضخامة الدماغ وتعدد التلافيف وكثرة الأصابع واستسقاء الدماغ من النوع الثاني في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Clinical-Grade Diagnostic Certainty. At-Home Convenience. Full UAE Legal Compliance.
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- ✓ Premium Logistics: Hospital-Grade Home Collection via ISO-Certified Cold-Chain and VIP Mobile Phlebotomy (8 AM – 11 PM).
- ✓ Clinical Guidance: Telephonic Post-Test Consultation for result interpretation by a DHA-licensed specialist.
- ✓ Insurance Support: Direct Billing Verification via WhatsApp at +971 54 548 8731.
تحليل جيني دقيق يلتزم بقانون المسؤولية الطبية الاتحادي رقم 41 لسنة 2024، ويضمن حماية خصوصية البيانات وفقًا لقانون حماية البيانات الشخصية الإماراتي.
Test Overview
The AKT3 Genetic Test analyses the entire coding region of the AKT3 gene to detect pathogenic variants linked to Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Type 2 (MPPH2). This targeted, high-throughput assay empowers paediatric neurologists and clinical geneticists to confirm a molecular diagnosis, guide prognosis, and inform familial recurrence risks. يُستخدم هذا الاختبار لتأكيد التشخيص الجيني لمتلازمة ضخامة الدماغ وتعدد التلافيف وكثرة الأصابع واستسقاء الدماغ من النوع الثاني الناتجة عن طفرات في جين AKT3.
| Feature | Our Test: Targeted AKT3 NGS | Closest Alternative: Whole Exome Sequencing (WES) |
|---|---|---|
| Precision & Depth | >99.9% coverage of AKT3 coding exons ±20 bp splice sites at >50x | Variable coverage; AKT3 often drops to <20x depth, risking false negatives |
| Methodology | Next-Generation Sequencing (NGS) with custom tiling | NGS with whole-exome capture; secondary analysis required for single gene |
| Turnaround Time | 3 to 4 weeks | 6 to 10 weeks |
| Clinical Focus | Dedicated to MPPH2, actionable results | Broad, unsolicited findings require extensive counselling |
Physician Insight & Safety Protocol
“As a paediatric clinician, I understand the anxiety families face when a child presents with macrocephaly, polymicrogyria, or polydactyly. This targeted AKT3 test is the definitive molecular step after a suggestive MRI or clinical finding, but it must always be interpreted in the context of a thorough physical examination and family history. Never rely on a genetic result alone to guide major treatment decisions.”
— Dr. Prabhakar Reddy, Specialist Pediatrician (DHA License: 61713011)
⚠ Medication Alert: Do not discontinue prescribed antiepileptic drugs, diuretics, or any other medication without consulting your physician, even if a genetic result is normal. Abrupt withdrawal can precipitate severe neurological deterioration.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to obtain legally valid informed consent as per UAE CDS Law 2026 (for minors, both parents/guardian must consent); severe anaemia (Hb <7 g/dL) requiring medical optimisation before phlebotomy.
- ER Red Flags: Acute-onset projectile vomiting, sunsetting eyes, bulging fontanelle, or rapid head growth in an infant — these indicate urgent hydrocephalus and require immediate neurosurgical evaluation, regardless of genetic test status.
Patient FAQ & Clinical Guidance
Q: What is the AKT3 gene test for, and who should consider it?
A definitive genetic diagnosis for infants and children with clinical or MRI features of MPPH2—including megalencephaly, polymicrogyria, polydactyly, and/or hydrocephalus—should be pursued when a specialist suspects an AKT3-related disorder. (The test clarifies prognosis, guides neurosurgical and developmental interventions, and informs recurrence risk for future pregnancies.)
ما هو فحص الجين AKT3 ومن يجب أن يخضع له؟ هو تحليل جيني دقيق لتأكيد الإصابة بمتلازمة MPPH2 لدى الرضع والأطفال الذين تظهر عليهم علامات تضخم الدماغ أو كثرة الأصابع أو استسقاء الدماغ.
Q: How is the sample collected for this genetic test in Dubai?
A certified paediatric phlebotomist visits your home or hospital room to draw 2–3 mL of blood using a neonatal/pediatric butterfly kit; the sample is immediately stabilised on a DNA FTA card or EDTA tube and transported under ISO 9001:2015 cold-chain within 2 hours. (Alternate saliva or buccal swabs are not accepted for this high-sensitivity NGS.)
كيف يتم جمع العينة لهذا الاختبار الجيني في دبي؟ يقوم اختصاصي سحب دم أطفال بزيارة منزلكم لأخذ عينة دم وريدية صغيرة، ثم تُحفظ في بطاقة FTA أو أنبوب EDTA وتُنقل بسلسلة تبريد معتمدة إلى المختبر.
Q: What do the results mean for my child’s treatment?
A positive (pathogenic) AKT3 variant confirms the molecular cause of MPPH2, enabling tailored neurosurgical planning, developmental therapies, and accurate genetic counselling; a negative result does not rule out other genetic aetiologies and warrants broader testing. (Clinical management remains based on the child’s symptoms, not the genetic result alone, under Dr. Reddy’s guidance.)
ماذا تعني النتائج لعلاج طفلي؟ النتيجة الإيجابية تؤكد التشخيص الجيني وتُوجه خطة جراحة الأعصاب والعلاجات التأهيلية، بينما لا تستبعد النتيجة السلبية أسبابًا جينية أخرى وتستدعي فحوصات أوسع.
UAE Regulatory Compliance:
- Licensed by Dubai Health Authority (Facility License: 9834453).
- Operates under Federal Decree-Law No. 41 of 2024 on Medical Liability (Art. 87), the Child Data Safety (CDS) Law 2026 for minors, and UAE PDPL.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) – Cold-chain logistics and genetic counselling protocols validated.
- Support: +971 54 548 8731 (WhatsApp) for billing, scheduling, and physician enquiry.
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