Test Price
2,800 AED✅ Home Collection Available
AKT3 Gene Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Type 2 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Clinical-Grade Diagnostic Certainty. At-Home Convenience. Full UAE Legal Compliance.
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- ✓ Premium Logistics: Hospital-Grade Home Collection via ISO-Certified Cold-Chain and VIP Mobile Phlebotomy (8 AM – 11 PM).
- ✓ Clinical Guidance: Telephonic Post-Test Consultation for result interpretation by a DHA-licensed specialist.
- ✓ Insurance Support: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The AKT3 Genetic Test analyses the entire coding region of the AKT3 gene to detect pathogenic variants linked to Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Type 2 (MPPH2). This targeted, high-throughput assay empowers paediatric neurologists and clinical geneticists to confirm a molecular diagnosis, guide prognosis, and inform familial recurrence risks.
| Feature | Our Test: Targeted AKT3 NGS | Closest Alternative: Whole Exome Sequencing (WES) |
|---|---|---|
| Precision & Depth | >99.9% coverage of AKT3 coding exons ±20 bp splice sites at >50x | Variable coverage; AKT3 often drops to <20x depth, risking false negatives |
| Methodology | Next-Generation Sequencing (NGS) with custom tiling | NGS with whole-exome capture; secondary analysis required for single gene |
| Turnaround Time | 3 to 4 weeks | 6 to 10 weeks |
| Clinical Focus | Dedicated to MPPH2, actionable results | Broad, unsolicited findings require extensive counselling |
Physician Insight & Safety Protocols
“As a paediatric clinical geneticist, I understand the anxiety families face when a child presents with macrocephaly, polymicrogyria, or polydactyly. This targeted AKT3 test is the definitive molecular step after a suggestive MRI or clinical finding, but it must always be interpreted alongside a thorough physical examination and family history. A genetic result alone should never guide major treatment decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory: Medication Continuity
⚠ Do not discontinue prescribed antiepileptic drugs, diuretics, or any other medication without consulting your physician, even if a genetic result is normal. Abrupt withdrawal can precipitate severe neurological deterioration.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to obtain legally valid informed consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability (for minors, both parents or guardians must consent); severe anaemia (Hb <7 g/dL) requiring medical optimisation before phlebotomy.
- ER Red Flags: Acute-onset projectile vomiting, sunsetting eyes, bulging fontanelle, or rapid head growth in an infant — these indicate urgent hydrocephalus and require immediate neurosurgical evaluation, regardless of genetic test status.
Patient FAQ & Clinical Guidance
1. What is the AKT3 gene test for, and who should consider it?
A definitive genetic diagnosis for infants and children with clinical or MRI features of MPPH2—including megalencephaly, polymicrogyria, polydactyly, and hydrocephalus—should be pursued when a specialist suspects an AKT3-related disorder. The test clarifies prognosis, guides neurosurgical and developmental interventions, and informs recurrence risk for future pregnancies.
2. How is the sample collected for this genetic test in Dubai?
A certified paediatric phlebotomist visits your home or hospital room to draw 2–3 mL of blood using a neonatal or paediatric butterfly kit; the sample is immediately stabilised on a DNA FTA card or EDTA tube and transported under ISO 9001:2015 cold-chain within 2 hours. Saliva or buccal swabs are not accepted for this high-sensitivity NGS assay.
3. What do the results mean for my child’s treatment?
A positive pathogenic AKT3 variant confirms the molecular cause of MPPH2, enabling tailored neurosurgical planning, developmental therapies, and accurate genetic counselling. A negative result does not rule out other genetic aetiologies and warrants broader testing. Clinical management remains based on the child’s symptoms, not the genetic result alone, under the guidance of your genetic specialist.
UAE Regulatory & Data Privacy Adherence
- Licensed by Dubai Health Authority (DHA Facility License Number: 1143).
- Operates under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical safety and patient consent governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) – Cold-chain logistics and genetic counselling protocols validated.
- Support: +971 54 548 8731 (WhatsApp) for billing, scheduling, and physician enquiry.
Clinical & Logistical Metadata
| Test Name | AKT3 Gene Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Type 2 (MPPH2) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood (2–3 mL, EDTA tube or DNA FTA card). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) with custom tiling covering all coding exons ±20 bp splice sites at >50x depth |
| ICD-10-CM Code | Q04.8 |
| LOINC Code | 21636-2 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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