Test Price
2,800 AED✅ Home Collection Available
AKR1C4 Gene Sequencing (46,XY Sex Reversal Type 8 Modifier) – Dubai, UAE
Executive Summary & Core Metrics
Precision-Driven Genetic Assessment – DNA Labs UAE
- Diagnostic Sensitivity: 99.9% across all coding regions and splice sites via ISO 9001:2015 accredited NGS workflow.
- Home Collection Available: VIP Mobile Phlebotomy with ISO-certified cold-chain logistics, daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary post-test interpretive consultation with our Consultant Medical Genetics team.
- Insurance & Billing: Direct verification and support via WhatsApp at +971 54 548 8731.
- Price: 2,800 AED inclusive of pre-test counseling and full gene sequencing.
- Turnaround Time: 3–4 weeks from sample receipt to final report.
Test Overview & Methodology
The AKR1C4 gene sequencing test identifies pathogenic variants associated with 46,XY sex reversal type 8. This comprehensive analysis uses next-generation sequencing (NGS) to examine all coding exons and flanking splice-site regions, providing definitive molecular diagnosis and enabling accurate recurrence risk assessment for families.
| Feature | DNA Labs UAE – AKR1C4 Sequencing | Standard Panel Alternative |
|---|---|---|
| Methodology | Full-gene NGS with 100 bp paired-end reads, 99.9% coverage | Targeted Sanger sequencing of selected exons only |
| Diagnostic Sensitivity | 99.9% (all coding regions ±15 bp splice sites) | ~85% restricted to known hotspot variants |
| Turnaround Time | 3–4 weeks with ISO 9001:2015 logistics | 5–6 weeks batch processing |
| Pre-test Counseling | Included – certified genetic counselor session | Often optional at extra cost |
Physician Insight & Safety Protocols
“Understanding your genetic profile can be a profound step toward informed health decisions. At DNA Labs UAE, our genetics team provides compassionate, evidence-based guidance throughout the testing journey, ensuring every result is interpreted within the full clinical context of your personal and family history.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory – Medication and Diagnostic Context
Never alter or discontinue prescribed therapies based solely on genetic findings. Results must be correlated with clinical evaluation, biochemical markers, and imaging as directed by your treating specialist. This test provides diagnostic and risk-assessment information; therapeutic decisions require comprehensive medical supervision.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent; minors under 18 without parental or legal guardian consent in accordance with UAE Federal Law; hemodynamic instability contraindicating safe venipuncture.
- Red Flags – seek immediate care: Rapidly expanding hematoma or significant bleeding at collection site; fever, erythema, or purulent discharge suggesting infection; acute emotional distress requiring urgent psychiatric support.
Patient FAQ & Clinical Guidance
1. What is the AKR1C4 gene and how does it affect sex development?
The AKR1C4 gene encodes an enzyme involved in steroid hormone metabolism. Pathogenic variants can disrupt androgen biosynthesis, leading to 46,XY sex reversal type 8, a condition where individuals with a male karyotype present with female or ambiguous genitalia.
2. How is the test conducted, and what is the expected timeline?
A standard peripheral blood sample is collected through our VIP Mobile Phlebotomy service or at our Dubai Healthcare City facility. Full-gene NGS analysis is completed within 3–4 weeks under ISO 9001:2015 certified processing protocols.
3. Is genetic counseling a mandatory part of this test?
Yes. A pre-test genetic counseling session is mandatory to document a three-generation pedigree, assess inheritance patterns, and ensure informed consent. Post-test counseling is also provided to explain results and implications for family members.
4. Can this test determine the risk of passing the condition to children?
Yes. Once a pathogenic variant is identified, recurrence risk counseling and carrier testing for at-risk relatives can be arranged. Our genetics team will guide you through family screening options.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: DNA Labs UAE operates under DHA Facility License No. 1143 and adheres to all applicable UAE federal health regulations.
Data Protection: All genetic and clinical data are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Patient Safety & Consent: Clinical testing and patient consent procedures follow the standards set forth in Federal Decree-Law No. 4 of 2016 on Medical Liability.
Accreditations: ISO 9001:2015 certified (Cert. INT/EGQ/2509DA/3139). Strict cold-chain logistics and chain-of-custody protocols are maintained for every specimen.
Clinical & Logistical Metadata
| Test Name | AKR1C4 Gene Sequencing (46,XY Sex Reversal Type 8 Modifier) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) – full-gene coverage, 100 bp paired-end reads |
| ICD-10-CM Code | E25.8, Q56.1 |
| LOINC Code | 55233-1 |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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