Test Price
2,800 AED✅ Home Collection Available
ABCB4 Gene (Intrahepatic Cholestasis of Pregnancy Type 3) Next‑Generation Sequencing
Executive Summary & Core Metrics
Genetic Test in UAE – 2,800 AED | DHA Licensed Laboratory
DNA Labs UAE offers ABCB4 gene sequencing using Next‑Generation Sequencing (NGS) technology to detect pathogenic variants associated with intrahepatic cholestasis of pregnancy type 3 (ICP3). The test achieves 99.9% diagnostic sensitivity through ISO 9001:2015 certified processing, with VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection available daily from 8 AM to 11 PM.
- ✓Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Certified NGS Processing.
- ✓Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (8 AM – 11 PM daily).
- ✓Clinical Guidance: Telephonic Post‑Test Clinical Interpretation by our medical genetics team.
- ✓Insurance: Direct Billing Verification via WhatsApp: +971 54 548 8731
Test Overview & Methodology
The ABCB4 Genetic Test analyzes the ABCB4 gene for pathogenic variants causing intrahepatic cholestasis of pregnancy type 3 (ICP3), a severe hepatic disorder posing significant risks to both mother and fetus. This comprehensive NGS assay detects single nucleotide variants, small insertions or deletions, and copy‑number variations across the entire coding region of the ABCB4 gene.
| Feature | Our Test (NGS) | Conventional Sanger Sequencing |
|---|---|---|
| Precision | 99.9% sensitivity – full gene sequencing with copy‑number variation detection | Variable; may miss large deletions or duplications |
| Methodology | Next‑Generation Sequencing (Illumina®) + MLPA confirmation | Sanger sequencing of coding exons only |
| Turnaround | 3–4 weeks | 4–6 weeks |
| Clinical Utility | Comprehensive – detects all clinically significant variant types | Limited to point mutations and small indels |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
"As a Consultant Medical Genetics specialist, I emphasize that genetic testing for ABCB4-related intrahepatic cholestasis of pregnancy provides crucial insight into hereditary predisposition. However, clinical correlation with liver function tests, bile acid levels, and obstetric assessment remains essential for comprehensive patient management. Always consult your referring physician before making treatment decisions based on genetic findings."
Medication Safety Advisory
Do not discontinue prescribed medication without consulting your doctor.
Abrupt withdrawal of ursodeoxycholic acid, antihistamines, or vitamin K can worsen maternal liver function and increase fetal risk. Always consult your specialist before making changes to your medication regimen.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria:
- This test is not indicated for patients in active labour, individuals under 18 years without court-approved parental consent, or those unable to provide informed consent for genetic counselling.
Emergency Red Flags — Seek Immediate Medical Care:
- Sudden severe itching, jaundice, dark urine, right upper quadrant pain, decreased fetal movements, or signs of preterm labour.
Patient FAQ & Clinical Guidance
1. Who should consider taking the ABCB4 gene test for intrahepatic cholestasis of pregnancy?
This test is indicated for pregnant women with unexplained pruritus and elevated bile acids, particularly those with a family history of severe ICP or early‑onset disease. Genetic counselling prior to testing is mandatory to ensure informed decision‑making and accurate interpretation of results.
2. How is the sample collected and what is the consent process?
A DHA‑licensed phlebotomist performs VIP mobile phlebotomy at your home between 8 AM and 11 PM daily. A mandatory genetic counselling session is conducted beforehand to obtain written informed consent and construct a family pedigree chart. The whole blood sample is transported under temperature‑controlled cold chain to our ISO‑certified laboratory.
3. What do the results mean for my pregnancy and future health?
A positive result confirms a genetic predisposition to ICP3 and guides close monitoring and pharmacological management. A negative result does not exclude other cholestatic disorders, so continued clinical follow‑up remains essential. Our medical genetics team provides telephonic post‑test interpretation to help you understand your results.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Regulatory Compliance
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑restricted, and processed under explicit patient consent. Clinical safety and patient consent protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
DHA Facility License Number: 1143 | Laboratory Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Clinical & Logistical Metadata
| Test Name | ABCB4 Gene (Intrahepatic Cholestasis of Pregnancy Type 3) Next‑Generation Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral Venous) |
| Methodology Used | Next‑Generation Sequencing (Illumina®) + MLPA Confirmation |
| ICD-10-CM Code | O26.619 |
| LOINC Code | 21671-4 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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