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ABCB1 Gene Colchicine resistance Genetic Test

4,400 د.إ

-21%

The ABCB1 Gene Colchicine Resistance Genetic Test is a specialized diagnostic assessment offered by DNA Labs UAE, designed to evaluate an individual’s genetic predisposition to resist the effects of colchicine, a medication commonly used for treating conditions such as gout and familial Mediterranean fever (FMF). The test focuses on identifying variations in the ABCB1 gene, which encodes a protein that plays a critical role in drug transport and metabolism. Certain mutations in the ABCB1 gene can affect how colchicine is processed in the body, leading to reduced efficacy of the drug.

Understanding an individual’s ABCB1 gene status can be crucial for healthcare providers to make informed decisions regarding colchicine dosing and exploring alternative treatments if necessary. This genetic test is particularly valuable for patients who have not responded to standard colchicine therapy, as it helps in tailoring a more effective and personalized treatment plan.

DNA Labs UAE offers this genetic testing service at a cost of 4400 AED. The test involves a simple sample collection process, after which the sample is analyzed to detect any genetic variations associated with colchicine resistance. Results from the test provide comprehensive insights that can significantly impact the management of conditions for which colchicine is prescribed, ensuring patients receive the most appropriate and effective care based on their genetic makeup.

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ABCB1 Gene Colchicine resistance Genetic Test

Test Name: ABCB1 Gene Colchicine resistance Genetic Test

Components: DNA sample from blood

Price: 4400.0 AED

Report Delivery: 3 to 4 Weeks

Method: NGS Technology

Test Type: Metabolic Disorders

Doctor: General Physician

Test Department: Genetics

Pre Test Information: Clinical History of Patient who is going for ABCB1 Gene Colchicine resistance NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with Colchicine resistance.

Test Details

The ABCB1 gene, also known as the ATP-binding cassette subfamily B member 1 gene, encodes a protein called P-glycoprotein. This protein is responsible for transporting various substances out of cells, including drugs and toxins.

Colchicine is a medication commonly used to treat gout and other inflammatory conditions. However, some individuals may be resistant to the effects of colchicine due to genetic variations in the ABCB1 gene. These variations can affect the function of P-glycoprotein, leading to decreased drug transport and reduced response to colchicine.

To determine if an individual has genetic variations in the ABCB1 gene that may confer colchicine resistance, a genetic test called Next-Generation Sequencing (NGS) can be performed. NGS is a high-throughput sequencing technology that allows for the simultaneous analysis of multiple genes or the entire genome. In the case of colchicine resistance, specific regions of the ABCB1 gene would be sequenced to identify any variations or mutations.

By identifying these genetic variations, healthcare providers can better understand an individual’s response to colchicine and tailor their treatment accordingly. This information can be particularly useful in determining the appropriate dosage of colchicine or considering alternative treatment options for individuals who are resistant to the drug.

Test Name ABCB1 Gene Colchicine resistance Genetic Test
Components
Price 4400.0 AED
Sample Condition Blood
Report Delivery 3 to 4 Weeks
Method NGS Technology
Test type Metabolic Disorders
Doctor General Physician
Test Department: Genetics
Pre Test Information Clinical History of Patient who is going for ABCB1 Gene Colchicine resistance NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with Colchicine resistance
Test Details

The ABCB1 gene, also known as the ATP-binding cassette subfamily B member 1 gene, encodes a protein called P-glycoprotein. This protein is responsible for transporting various substances out of cells, including drugs and toxins.

Colchicine is a medication commonly used to treat gout and other inflammatory conditions. However, some individuals may be resistant to the effects of colchicine due to genetic variations in the ABCB1 gene. These variations can affect the function of P-glycoprotein, leading to decreased drug transport and reduced response to colchicine.

To determine if an individual has genetic variations in the ABCB1 gene that may confer colchicine resistance, a genetic test called Next-Generation Sequencing (NGS) can be performed. NGS is a high-throughput sequencing technology that allows for the simultaneous analysis of multiple genes or the entire genome. In the case of colchicine resistance, specific regions of the ABCB1 gene would be sequenced to identify any variations or mutations.

By identifying these genetic variations, healthcare providers can better understand an individual’s response to colchicine and tailor their treatment accordingly. This information can be particularly useful in determining the appropriate dosage of colchicine or considering alternative treatment options for individuals who are resistant to the drug.

SKU: TEST-2230 Category:

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