Test Price
5,100 AED✅ Home Collection Available
HLA Pre‑Transplant Workup (Sensitized Recipient Panel 5) in UAE – 5,100 AED
Executive Summary & Core Metrics
High‑resolution HLA antibody profiling for sensitised transplant candidates using Luminex single‑antigen bead and flow cytometry crossmatch technology. Detection sensitivity of 99.9% for donor‑specific antibodies (DSAs). Certified ISO 9001:2015 laboratory with temperature‑controlled cold‑chain logistics and VIP mobile phlebotomy available daily from 8 AM to 11 PM. Turnaround time of 10–12 working days from sample collection. Price: 5,100 AED inclusive of clinical interpretation.
Test Overview & Methodology
This panel employs reverse sequence‑specific oligonucleotide probe (SSOP) technology on the Luminex X‑MAP platform combined with flow cytometry crossmatch to detect and characterise anti‑HLA antibodies in recipients awaiting solid organ transplantation. The methodology distinguishes complement‑fixing from non‑complement‑fixing antibodies, enabling virtual crossmatch and epitope analysis for optimal donor selection and desensitisation planning.
| Feature | Our Panel (Luminex + Flow) | CDC‑Only Alternative |
|---|---|---|
| Methodology | Reverse SSOP (Luminex X‑MAP) & flow cytometry crossmatch | Complement‑dependent cytotoxicity (CDC) |
| Sensitivity | 99.9% – detects low‑level DSAs | Limited; may miss non‑complement‑fixing antibodies |
| Turnaround Time | 10–12 working days | 7–14 days (less informative) |
| Clinical Utility | Virtual crossmatch & epitope analysis ready | Rudimentary DSA detection |
Physician Insight & Safety Protocols
“Every sensitised patient’s immunological profile is unique; this panel delivers the granular data required to design personalised desensitisation protocols and virtual crossmatch strategies. Correlation with the recipient’s clinical history, donor factors, and prior transplant exposures is essential for accurate risk stratification. Our team works closely with HLA laboratory directors to ensure each report is interpreted within the full clinical picture.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice
Do not discontinue or alter any prescribed immunosuppressive, desensitisation, or anticoagulant medication without direct consultation with your transplant nephrologist or treating physician. Certain medications can interfere with assay interpretation and patient safety.
Exclusion Criteria & Red Flags
- Active severe infection or sepsis precluding safe blood draw.
- Haemodynamic instability or acute cardiovascular event within 72 hours.
- Known anaphylaxis to phlebotomy materials – inform the phlebotomist immediately.
- Recent administration of IVIg or rituximab: must be communicated to the laboratory before collection.
- Seek emergency care if you develop sudden shortness of breath, chest pain, or severe bleeding after sample collection.
Patient FAQ & Clinical Guidance
1. What is the purpose of this panel if I already have a living donor?
Even with a known living donor, pre‑formed donor‑specific antibodies can trigger hyperacute or accelerated rejection immediately after transplantation. This panel identifies those antibodies at very low concentrations, enabling a virtual crossmatch and safe transplantation planning. It also guides desensitisation therapy if needed.
2. How does this test differ from standard HLA typing?
Standard HLA typing determines your own tissue type alleles. This workup detects circulating anti‑HLA antibodies in your serum, measuring their strength and specificity against a comprehensive panel of potential donor antigens. It reveals your immunological barriers to transplantation, not just your genetic profile.
3. Can I still receive a transplant if my antibody levels are elevated?
Yes. Elevated antibody levels can be managed through desensitisation protocols, plasmapheresis, IVIg therapy, or careful donor selection using virtual crossmatch. This panel provides the immunological map required by your transplant team to design an effective treatment strategy and identify compatible donors.
4. What sample is required and are there special collection instructions?
We require 9 mL serum (minimum 6 mL) from three SSTs, plus 4 mL EDTA whole blood (lavender top), and 4 mL sodium heparin whole blood (green top). Collection is preferably performed 48 hours after dialysis. Ship the specimen at 18–22 °C — do not refrigerate or freeze. VIP mobile phlebotomy is available daily from 8 AM to 11 PM.
UAE Regulatory & Data Privacy Adherence
Legal & Compliance Framework
- Licensed by Dubai Health Authority (DHA Facility License No. 1143).
- Full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) — all health data encrypted and stored within UAE borders.
- Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical safety and patient consent governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 certified for quality management — certificate INT/EGQ/2509DA/3139, including cold‑chain logistics and laboratory operations.
Clinical & Logistical Metadata
| Test Name | HLA Pre‑Transplant Workup (Sensitized Recipient Panel 5) |
| Price (AED) | 5,100 |
| Turnaround Time | 10–12 working days |
| Sample Type / Matrix | Peripheral whole blood (EDTA, Sodium Heparin) and serum (SSTs) |
| Methodology Used | Reverse SSOP (Luminex X‑MAP) & Flow Cytometry Crossmatch |
| ICD-10-CM Code | Z94.9, Z13.9 |
| LOINC Code | 97489-7 |
| DHA Facility License & Laboratory Address | DHA License 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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