Test Price
1,800 AED✅ Home Collection Available
HLA DSA (Donor Specific IgG Antibodies) Class I & II Test in UAE | 1800 AED | DHA Licensed
Executive Summary & Core Metrics
Diagnostic Sensitivity: 99.9% via ISO 9001:2015 Certified Luminex Single Antigen Bead Technology. Turnaround Time: 10–12 calendar days from sample receipt. Collection: VIP Mobile Phlebotomy with temperature-controlled cold-chain home collection, available daily 8 AM–11 PM. Insurance billing directly via WhatsApp (+971 54 548 8731). Post-test clinical guidance included with every report.
Test Overview & Methodology
The HLA DSA Class I & II assay employs advanced Luminex single-antigen bead (SAB) flow-based technology to detect and quantify donor-specific IgG antibodies against both Class I (HLA-A, B, C) and Class II (HLA-DR, DQ, DP) loci. This high-resolution method is the gold standard for pre- and post-transplant immunological risk assessment, offering superior sensitivity and specificity over traditional complement-dependent cytotoxicity (CDC) crossmatch assays. The multi-step bead processing includes antigen extraction, serum incubation, fluorescent detection, and software-based analysis of mean fluorescence intensity (MFI) values.
| Feature | Our Test (Luminex DSA) | CDC Crossmatch (Alternative) |
|---|---|---|
| Methodology | Luminex Single Antigen Bead (SAB) flow-based assay | Complement-dependent cytotoxicity (CDC) on donor lymphocytes |
| Sensitivity | >99% detection of HLA-specific IgG antibodies | Lower sensitivity; may miss low-titer or non-complement-fixing antibodies |
| Turnaround Time | 10–12 days | 24–48 hours |
| Clinical Specificity | Identifies specific donor HLA target alleles; predicts antibody-mediated rejection risk | Detects preformed antibodies only; limited chronic rejection prediction |
Physician Insight & Safety Protocols
“As a general practitioner supporting transplant recipients, I emphasize that a positive DSA result must always be interpreted alongside serial graft function markers, biopsy findings, and clinical presentation. This test is a critical risk-stratification tool, not a definitive diagnosis of rejection. Always share results with your transplant nephrologist before making any therapeutic adjustments.”
— Dr. Ajay Singh, General Practitioner | DHA Registration ID: 36234132
Advisory & Safety Precautions
Medication Stability Warning
Sudden cessation or alteration of immunosuppressive therapy can precipitate acute graft rejection or graft loss. All medication changes must be directed and supervised by your transplant physician. Never adjust dosing based solely on DSA values.
Exclusion Criteria & ER Red Flags
Exclusion Criteria for Specimen Collection
- Blood draw performed within 48 hours after hemodialysis session (may yield false-negative results).
- Missing mandatory documentation: signed physician referral on official letterhead with stamp, and recent photographs of both recipient and donor.
- Active severe systemic infection or recent IVIG therapy within 4 weeks (may confound antibody interpretation).
ER Red Flags – Seek Emergency Care If:
- Fever >38.5°C with chills or rigors.
- Oliguria or anuria in kidney transplant recipients.
- New-onset graft tenderness, swelling, or erythema.
- Dyspnea, chest pain, or palpitations (cardiac transplant).
Patient FAQ & Clinical Guidance
1. What is the HLA DSA Class I & II test?
This blood test uses Luminex bead technology to detect donor-specific anti-HLA antibodies (IgG) that can mediate antibody-mediated rejection. It provides a detailed specificity profile against individual HLA antigens of the donor, enabling precise immunological risk stratification before and after transplantation.
2. Why must I wait 48 hours after dialysis before the blood draw?
Hemodialysis can transiently remove circulating antibodies through membrane filtration and adsorption, leading to artificially low antibody levels. A 48-hour window ensures accurate baseline DSA detection and eliminates false-negative results that could misguide clinical decisions.
3. How long will it take to get my results?
Results are typically reported within 10–12 calendar days from the date of specimen collection. The turnaround time accounts for multi-step Luminex bead processing, including antigen coupling, serum incubation, washing, fluorescent labeling, and data acquisition on a flow analyzer, followed by expert clinical correlation.
4. Can I take my usual medications before the test?
Yes, continue all prescribed immunosuppressive and maintenance medications unless explicitly directed otherwise by your transplant physician. The test measures antibody levels reflective of your current immunological state under your existing regimen.
5. How is home collection arranged?
Our VIP Mobile Phlebotomy service dispatches a trained nurse to your residence between 8 AM and 11 PM, seven days a week. All samples are transported under temperature-controlled cold-chain conditions to our Dubai Healthcare City laboratory. Same-day courier delivery to the lab is included in the test price.
UAE Regulatory & Data Privacy Adherence
Regulatory Framework: DNA Labs UAE operates under DHA Facility License Number 1143 and adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for all patient data handling, storage, and transmission. Our clinical safety and consent protocols comply with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields and Federal Decree-Law No. 4 of 2016 on Medical Liability. ISO 9001:2015 Certification: INT/EGQ/2509DA/3139.
Clinical & Logistical Metadata
| Test Name | HLA DSA (Donor Specific IgG Antibodies) Class I & II |
| Price (AED) | 1,800 AED |
| Turnaround Time | 10–12 calendar days from sample receipt |
| Sample Type / Matrix | Serum (peripheral venous blood); VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM–11 PM) |
| Methodology Used | Luminex Single Antigen Bead (SAB) Flow-Based Immunoassay |
| ICD-10-CM Code | Z94.0 (Kidney transplant status), T86.1 (Complications of transplanted kidney) |
| LOINC Code | 48319-8 (HLA DSA Class I), 48320-6 (HLA DSA Class II) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians