Test Price
2,800 AEDโ Home Collection Available
UQCRC2 Gene Mitochondrial Complex III Deficiency Genetic Test in UAE | 2800 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
This advanced genetic test delivers next-generation sequencing (NGS) of the UQCRC2 gene to detect pathogenic variants causing mitochondrial complex III deficiency. With a diagnostic sensitivity exceeding 99.9%, it is performed at an ISO 9001:2015 certified laboratory (Cert: INT/EGQ/2509DA/3139). The service includes VIP mobile phlebotomy and temperature-controlled cold-chain home collection, plus a complimentary post-test telephone consultation with a Consultant Medical Geneticist.
- Precision: 99.9% diagnostic sensitivity using Illumina NGS platform with LC-MS/MS quality control.
- Logistics: DHA-licensed mobile phlebotomy team, cold-chain equipped vehicle โ home collection daily from 8 AM to 11 PM.
- Clinical Support: Free post-test genetic counselling with Lina Osama Zaki Quteineh (Consultant Medical Genetics | DHA: 9294403).
- Insurance: Direct coverage verification via WhatsApp (+971545488731) and billing with all major UAE insurers.
Test Overview & Methodology
This comprehensive test sequences the entire UQCRC2 gene using next-generation sequencing (NGS) to identify point mutations, indels, and copy-number variants linked to mitochondrial complex III deficiency โ a rare neurometabolic disorder. The analysis covers all coding exons and flanking intronic regions, with variant interpretation per ACMG 2024 guidelines. The test confirms molecular diagnosis in patients with hypotonia, developmental delay, seizures, or lactic acidosis, and enables accurate cascade family screening.
| Feature | Our Test (NGS UQCRC2) | Closest Alternative (Mitochondrial Panel Sanger) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity; detects all variant types including heteroplasmy | ~95% sensitivity; may miss low-level heteroplasmy |
| Methodology | Next Generation Sequencing (Illumina platform with LC-MS/MS quality control) | Sanger sequencing of select exons |
| Speed | Results in 3โ4 Weeks | 4โ6 Weeks |
Physician Insight & Safety Protocols
โI understand the anxiety a potential mitochondrial diagnosis brings. This test is a critical piece of the puzzle, but it must be correlated with a full neurological examination and metabolic workup. A genetic result alone does not replace your neurologistโs clinical judgment โ we are here to guide you through every step.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA License: 9294403)
Advisory Notice
โ ๏ธ Medication Warning
Do not discontinue any prescribed medication or supplement without consulting your physician. Abrupt cessation can destabilize metabolic conditions.
Exclusion Criteria & Emergency Red Flags
- Active febrile illness or systemic infection within the last 48 hours.
- Receipt of blood transfusion or hematopoietic cell transplant within the past 4 weeks.
- Inability to provide a peripheral blood sample (severe IV access issues).
- Seek immediate emergency care if the patient develops: acute onset of lethargy, vomiting, breathing difficulties, or seizures โ signs of a metabolic crisis or encephalopathy.
Patient FAQ & Clinical Guidance
1. What is the UQCRC2 gene test used for?
This test uses NGS to identify UQCRC2 mutations causing mitochondrial complex III deficiency, a rare neurological disease. It confirms the molecular diagnosis in patients with symptoms like hypotonia, developmental delay, seizures, or lactic acidosis, and enables accurate family screening. The report provides variant interpretation per ACMG 2024 guidelines, directly guiding targeted management and genetic counselling.
2. How is the sample collected and what is the turnaround time?
A blood sample is collected via VIP mobile phlebotomy and analyzed using NGS technology, with results in three to four weeks. Our DHA-licensed mobile team arrives at your doorstep in a temperature-controlled cold-chain vehicle and collects either whole blood, extracted DNA, or a single drop of blood on an FTA card. The sample is transported to the ISO-certified laboratory, and the report is released after expert review. No hospital visit is required.
3. Are my results confidential and covered by insurance?
Test results are strictly confidential per UAE privacy law, and we verify your insurance coverage directly via WhatsApp. All genomic data is stored securely under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning health ICT. We handle direct billing with all major UAE insurers; simply share your policy number through +971545488731 and we will confirm coverage before the test.
UAE Regulatory & Data Privacy Adherence
๐ฅ Regulatory Compliance: This test complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic counselling and sample collection adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Laboratory operations are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and follow DHA/MOHAP standard nomenclature for all analytes. DHA tele-health and home services regulations govern remote consultations and mobile phlebotomy.
Clinical & Logistical Metadata
| Test Name | UQCRC2 Gene Mitochondrial Complex III Deficiency Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3โ5 mL in EDTA tube), or extracted genomic DNA, or FTA card spot. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AMโ11 PM. |
| Methodology Used | Next Generation Sequencing (Illumina platform, LC-MS/MS quality control) |
| ICD-10-CM Code | E88.49 (Other disorders of mitochondrial metabolism) |
| LOINC Code | 92653-0 (UQCRC2 gene mutation detection) |
| DHA Facility License & Laboratory Address | License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians