Test Price
2,800 AED✅ Home Collection Available
CBL Gene Juvenile Myelomonocytic Leukemia (JMML) Genetic Test in UAE | 2800 AED | DHA Approved
Executive Summary & Core Metrics
This advanced Next-Generation Sequencing (NGS) analysis detects germline CBL mutations driving Juvenile Myelomonocytic Leukemia (JMML) with ≥99.9% diagnostic sensitivity, backed by ISO 9001:2015 certified processing and DHA-compliant protocols. Services include VIP mobile phlebotomy and temperature-controlled home collection daily from 8 AM to 11 PM, post-test clinical guidance, and direct insurance billing verification via WhatsApp at +971 54 548 8731. All procedures strictly adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and Federal Decree-Law No. 4 of 2016 on Medical Liability.
Test Overview & Methodology
The CBL gene NGS test screens for germline pathogenic variants associated with JMML and Noonan‑like RASopathy, enabling early diagnosis, risk stratification, and informed clinical management. In contrast to conventional Sanger sequencing, this NGS platform delivers near‑exhaustive coverage of the entire CBL coding region with validated bioinformatics pipelines.
| Feature | Our CBL NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Sensitivity | ≥99.9% (detects all clinically reportable SNVs, indels, and CNVs) | 80–85% (limited to targeted exons, may miss deep intronic or large deletions) |
| Methodology | NGS (Next‑Generation Sequencing) with ISO 9001:2015 validated pipeline | Capillary electrophoresis Sanger sequencing |
| Turnaround Time | 3 to 4 weeks | 5 to 7 weeks (longer for full gene coverage) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
"This test is a powerful diagnostic tool that must always be interpreted together with the full clinical picture, family history, and expert genetic counselling. A positive germline CBL mutation can guide targeted surveillance, but it does not automatically equate to active leukemia. I strongly urge every family to discuss results with their paediatric haematologist‑oncologist and never stop prescribed medications without medical supervision."
Important Medication Advisory
Do not alter or discontinue any prescribed treatment plan based solely on this test result. Only a qualified physician familiar with the complete medical history can recommend safe changes. Always follow the guidance of your child’s primary specialist.
Exclusion Criteria & Emergency Red Flags
- Age less than 1 year (test not indicated without prior specialist recommendation)
- Unaccompanied minors – mandatory guardian consent and presence required
- Active severe infection or uncompensated coagulopathy at time of blood draw
- Emergency Red Flags: new onset fever >38.5°C, abnormal bleeding/bruising, respiratory distress, or rapid clinical deterioration – seek immediate emergency care, not a scheduled lab visit.
Patient FAQ & Clinical Guidance
1. What is the purpose of the CBL gene NGS test?
This identifies inherited (germline) mutations in the CBL gene that predispose to juvenile myelomonocytic leukemia and related RASopathies, enabling early risk assessment and personalised surveillance.
2. What sample is needed and how long does the result take?
A standard blood sample (whole blood, extracted DNA, or one drop on an FTA card) is required, and results are typically issued within 3 to 4 weeks from receipt of a properly collected specimen.
3. Is home collection available and does insurance cover it?
Yes, we provide VIP mobile phlebotomy and hospital‑grade home collection from 8 AM to 11 PM; direct insurance billing verification can be done via WhatsApp before the appointment.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring all patient genomic and clinical data are securely processed, stored, and transmitted. Additionally, the laboratory adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, guaranteeing the integrity and confidentiality of electronic health records. All clinical procedures are conducted under the framework of Federal Decree-Law No. 4 of 2016 on Medical Liability, safeguarding patient consent and safety throughout the testing pathway.
Clinical & Logistical Metadata
| Test Name | CBL Gene Juvenile Myelomonocytic Leukemia (JMML) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole blood, extracted DNA, or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | C93.1 |
| LOINC Code | 60348-4 |
| DHA Facility License & Laboratory Address | DHA License: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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