Test Price
2,800 AED✅ Home Collection Available
SMAD4 Gene Test (Juvenile Polyposis & HHT) NGS DNA Sequencing in UAE | AED 2800
Executive Summary & Core Metrics
Accuracy Guarantee
99.9% Diagnostic Sensitivity (ISO Certified Lab)
Premium Logistics
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM – 11 PM)
Clinical Guidance
Telephonic Post-Test Genetic Counseling with Consultant Medical Geneticist
Insurance
Direct Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
SMAD4 Gene NGS Test – Next‑Generation Sequencing identifies germline pathogenic variants in the SMAD4 tumor suppressor gene, enabling precise risk stratification for Juvenile Polyposis Syndrome (JPS) and Hereditary Hemorrhagic Telangiectasia (HHT).
| Feature | Our Test (NGS‑Powered) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | >99.9% analytical sensitivity & full gene coverage | Limited to selected exons; lower sensitivity |
| Methodology | Next‑Generation Sequencing (Illumina®) | Capillary Sanger Sequencing |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
Physician Insight & Safety Protocols
“A positive SMAD4 variant requires lifelong surveillance; however, many carriers lead healthy lives with appropriate monitoring and early interventions. I always emphasize that genetic findings must be interpreted in the context of personal and family history, and should never replace comprehensive clinical evaluation.”
Lina Osama Zaki Quteineh – Consultant Medical Genetics (DHA Registration ID: 9294403)
Medication Advisory
⛔ Do Not Self-Adjust Therapy
Never discontinue or modify prescribed medications based solely on genetic test results without consulting your treating physician. Self-adjusting therapy can lead to serious health complications. Genetic insights are meant to complement, not replace, medical supervision.
Safety Exclusion Criteria & Red Flags
- This test is not performed on individuals under 18 years without legal guardian consent, in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability and DHA regulations.
- Exclusion: Acute gastrointestinal bleeding, recent blood transfusion (< 2 weeks), or active chemotherapy – please confirm eligibility with our genetic counsellor before scheduling.
- Seek Emergency Care if you experience sudden severe rectal bleeding, acute intestinal obstruction, or unexplained severe nosebleeds accompanied by dizziness.
Patient FAQ & Clinical Guidance
1. What does this SMAD4 gene test detect?
Snippet‑optimised answer: This test identifies germline pathogenic variants in the SMAD4 gene responsible for Juvenile Polyposis Syndrome and Hereditary Hemorrhagic Telangiectasia, enabling early cancer surveillance and vascular complication management.
2. How is the sample collected for this genetic test?
Snippet‑optimised answer: A simple blood draw, extracted DNA, or dried blood spot on an FTA card is collected at your home by a certified phlebotomist under cold‑chain protocols, ensuring sample integrity.
3. How long do I wait for results and who interprets them?
Snippet‑optimised answer: Results are ready in 3–4 weeks and include a telehealth consultation with a clinical geneticist who explains cancer risk implications and next‑steps.
UAE Regulatory & Data Privacy Adherence
This test is performed at a DHA-licensed facility (License: 1143) and complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is handled with the highest confidentiality and security standards.
Clinical & Logistical Metadata
| Test Name | SMAD4 Gene Test (Juvenile Polyposis & HHT) NGS DNA Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Blood, Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (Illumina®) |
| ICD-10-CM Code | K63.5, I78.0 |
| LOINC Code | 21645-8 |
| DHA Facility License & Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | License: 1143 | Lab: DNA Labs UAE |
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