Test Price
2,800 AED✅ Home Collection Available
DDX11-Related Warsaw Breakage Syndrome Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Clinical Guidance: Post-test clinical review and interpretation by a DHA-licensed Consultant Medical Genetics specialist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The DDX11-Related Warsaw Breakage Syndrome Genetic Test is a comprehensive next-generation sequencing analysis of the entire coding region and splice junctions of the DDX11 gene. It identifies pathogenic variants responsible for Warsaw breakage syndrome, a rare autosomal recessive chromosome instability disorder characterized by microcephaly, pre- and post-natal growth deficiency, dysmorphic features, and increased cancer predisposition. This test is essential for confirming a clinical diagnosis, guiding oncology surveillance, and informing reproductive planning.
| Our Test – Precision NGS | Closest Alternative – Chromosome Breakage Assay |
|---|---|
| Methodology: Next-Generation Sequencing (NGS) with ≥ 100× mean read depth and gap-fill Sanger confirmation. | Method: Mitomycin C-induced or diepoxybutane-induced chromosome breakage study. |
| Turnaround: 3 to 4 Weeks. | Turnaround: 2–4 Weeks. |
| Specimen: Whole blood, extracted DNA, or dried blood spot on FTA card. | Specimen: Peripheral blood lymphocytes (fresh sample required). |
| Price: 2800 AED. | Price: Typically 800–1500 AED. |
| Coverage: All exons, ±20 bp flanking intronic regions, CNV detection. | Limitation: Functional test only; does not identify the specific DDX11 variant or distinguish from other breakage syndromes. |
Physician Insight & Safety Protocols
“As a Consultant in Medical Genetics, I emphasize that DDX11 gene sequencing must be interpreted alongside the complete clinical phenotype and a three-generation pedigree. A negative result does not eliminate the possibility of other chromosome instability syndromes such as Fanconi anemia or Nijmegen breakage syndrome. The genetic findings serve as one component of a comprehensive clinical management strategy, not a standalone diagnostic verdict.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Maintain all current medications as prescribed by your physician; this genetic test does not evaluate drug efficacy or metabolism pathways. Do not alter or stop any treatment without direct consultation with your managing specialist.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Active severe bleeding disorder, acute febrile illness, or inability to provide informed consent (for minors, legal guardian consent mandatory).
- Red Flags – Seek urgent medical attention if: Sudden neurological deterioration, new seizures, unexplained bruising/bleeding suggestive of bone marrow failure, or rapid onset of lymph node enlargement.
Patient FAQ & Clinical Guidance
1. What is Warsaw breakage syndrome and why is DDX11 gene testing recommended?
Warsaw breakage syndrome is a rare autosomal recessive disorder caused by DDX11 mutations, leading to microcephaly, growth failure, and chromosome instability that raises cancer risk – testing confirms the diagnosis and guides surveillance.
2. How is the sample collected and what are the pre-test requirements?
A blood draw or a simple finger-prick dried blood spot on an FTA card is collected by a certified phlebotomist; prior genetic counselling to map family history is mandatory before the analysis.
3. What do negative or variant-of-uncertain-significance (VUS) results mean?
A negative result lowers suspicion for DDX11-related syndrome but does not exclude other chromosome breakage disorders, and a VUS requires periodic reinterpretation with new evidence and clinical correlation.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: This laboratory adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All analyses are performed under ISO 9001:2015 quality management (Cert: INT/EGQ/2509DA/3139). Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. DHA Facility License: 1143. WhatsApp: +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | DDX11-Related Warsaw Breakage Syndrome Genetic Test |
| Price (AED) | 2800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole blood, extracted DNA, or dried blood spot on FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) with ≥ 100× mean read depth and Sanger confirmation |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 95451-2 |
| DHA Facility License & Laboratory Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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