Test Price
2,800 AED✅ Home Collection Available
UQCC2 Single-Gene NGS Test for Mitochondrial Complex III Deficiency, Nuclear Type 7 in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary – This NGS test delivers diagnostic sensitivity >99% for UQCC2-related mitochondrial complex III deficiency, with verified cold-chain home collection and post-test genetic counseling.
- 99.9% Diagnostic Sensitivity – Validated via ISO 9001:2015 accredited molecular diagnostics.
- Premium Logistics – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM daily).
- Clinical Guidance – Complimentary telephonic post-test clinical correlation session with a specialist.
- Insurance Support – Direct billing verification through WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This single-gene next-generation sequencing (NGS) test targets the entire coding region of UQCC2, the gene responsible for nuclear type 7 mitochondrial complex III deficiency. It provides a definitive molecular diagnosis in children and adults presenting with dysmorphology, encephalopathy, myopathy, or multi‑organ failure, and is integral for accurate genetic counselling and family planning.
| Feature | Our UQCC2 Single-Gene NGS Test | Closest Alternative (Whole Exome / Panel) |
|---|---|---|
| Precision | >99% analytical sensitivity & specificity for UQCC2 | Variable coverage; lower depth for single gene |
| Methodology | Targeted NGS (Illumina® platform, full exon capture) | Whole exome/ mitochondrial genome NGS |
| Speed (TAT) | 3–4 Weeks | 6–8 Weeks (typically) |
| Cost (UAE) | 2,800 AED | 5,000 – 9,000 AED |
| Clinical Utility | Immediate confirmation of UQCC2-linked disease | Broad but requires secondary analysis |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I have seen the profound impact that a precise molecular diagnosis of mitochondrial complex III deficiency can have on a family. This targeted NGS test, when integrated with a thorough clinical and biochemical evaluation, provides clarity that guides management and reproductive decisions. It is essential that results are interpreted in the context of the full clinical picture.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Safety Precautions
⚠ Important Advisory: Do not discontinue any prescribed medication, including supplements or anti‑epileptics, without explicit instruction from your treating physician. Results from this test may take 3–4 weeks and should not delay emergency care for acute metabolic crises.
Exclusion & Safety Criteria
- Minors (<18) must have parental/legal guardian consent compliant with UAE Federal Law No. 2 of 2019.
- Patients with acute febrile illness or coagulopathy – sample collection may be rescheduled.
- Lack of informed consent or inability to understand the genetic implications.
- If the patient experiences seizures, acute respiratory distress, severe repetitive vomiting, or sudden lethargy prior to or during the collection window, seek immediate emergency care. This test does not substitute for acute metabolic crisis management.
Patient FAQ & Clinical Guidance
1. What is the UQCC2 gene test and why is it performed?
The UQCC2 NGS test detects pathogenic variants causing mitochondrial complex III deficiency, confirming the diagnosis for accurate medical management and reproductive planning. This targeted genetic analysis is essential for individuals with clinical signs such as developmental delay, hypotonia, seizures, or dysmorphic features, especially in the pediatric population. It enables precise prognosis assessment and carrier testing within families.
2. How is the sample collected and what preparation is needed?
A simple blood draw or DNA FTA card collection is performed via VIP mobile phlebotomy at your home; no fasting is required, but please inform us of any anticoagulant therapy. Our DHA‑licensed mobile team visits between 8 AM and 11 PM under strict cold‑chain protocol. For infants, a single drop of blood on an FTA card may be sufficient. A genetic counseling session is arranged beforehand to draw a family pedigree and review clinical history for accurate interpretation.
3. How quickly will I get results and what do they mean?
The final report is delivered in 3–4 weeks. A positive result confirms UQCC2-related mitochondrial disease, while a negative result substantially reduces that specific diagnostic likelihood. All reports are reviewed by a molecular geneticist and clinically correlated. If a pathogenic variant is found, we provide a comprehensive interpretation including implications for treatment and future pregnancies. Our telephonic post‑test session ensures you fully understand the findings.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
This service fully adheres to the following UAE legal standards:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – all genetic data is processed and stored within UAE sovereign infrastructure.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – ensuring secure handling of health information.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – covering clinical safety and patient consent.
- ISO 9001:2015 certified laboratory processes.
Clinical & Logistical Metadata
| Test Name | UQCC2 Single-Gene NGS Test for Mitochondrial Complex III Deficiency, Nuclear Type 7 |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood or FTA card blood spot; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM daily) |
| Methodology Used | Targeted Next-Generation Sequencing (Illumina® platform, full exon capture) |
| ICD-10-CM Code | E88.89 (Other specified metabolic disorders) – also applicable codes: G71.3 (Mitochondrial myopathy), E88.8 (Other metabolic disorders) |
| LOINC Code | 96409-4 (Mitochondrial complex III deficiency gene panel) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – Operated by DNA Labs UAE |
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