Test Price
2,800 AEDโ Home Collection Available
UGT1A1 Gene Crigler-Najjar Syndrome Type 2 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (ISO 9001:2015, Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paired Hospital-Grade Home Collection using ISO-Certified Cold-Chain VIP Mobile Phlebotomy, available daily 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation and next-step planning.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Regulatory Compliance: Fully aligned with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 on Health ICT.
Test Overview & Methodology
The UGT1A1 Genetic Test delivers comprehensive sequencing of the UGT1A1 gene to diagnose Crigler-Najjar syndrome type 2, an inherited liver disorder causing mild to moderate unconjugated hyperbilirubinemia. This state-of-the-art test, available with VIP home collection across the UAE, provides 99.9% diagnostic accuracy and results within 3โ4 weeks, empowering timely clinical decisions.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Precision | 99.9% Sensitivity | 95โ98% |
| Methodology | Next-Generation Sequencing (NGS) | Single-gene Sanger |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Sample Types Accepted | Whole Blood, Extracted DNA, FTA Card | Whole Blood only |
Intended Ordering Specialists: Clinical Geneticists, Hepatologists, and General Physicians โ for diagnostic confirmation, carrier screening, and pharmacogenomic guidance.
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
โThis NGS-based genetic test provides definitive molecular confirmation of Crigler-Najjar syndrome type 2 by identifying pathogenic variants in the UGT1A1 gene. While a positive result establishes the diagnosis, a negative result does not exclude all forms of unconjugated hyperbilirubinemia. Results must be interpreted alongside liver function tests and a full clinical assessment by a treating hepatologist or genetic counselor.โ
Pre-Test Advisory & Medication Safety
Medication Safety Advisory
Do not discontinue or alter any prescribed medication without consulting your treating physician. This genetic test informs pharmacogenomic dosing recommendations but does not replace clinical judgment regarding drug therapy adjustments.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent; active severe bleeding disorder; non-consenting minors (per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Emergency Red Flags: Sudden jaundice with confusion, high fever, severe abdominal pain, or signs of acute liver failure โ seek immediate emergency care at the nearest hospital.
Patient FAQ & Clinical Guidance
1. What does the UGT1A1 genetic test for Crigler-Najjar syndrome type 2 detect?
Answer: This NGS test identifies pathogenic gene variants in the UGT1A1 gene that cause Crigler-Najjar syndrome type 2, an inherited disorder characterized by unconjugated hyperbilirubinemia. It sequences the entire coding region, detecting point mutations, small insertions and deletions, and copy number variations that reduce UGT1A1 enzyme activity. The result helps differentiate type 2 from the more severe type 1 and guides long-term monitoring and treatment planning.
2. Why is this genetic test recommended before certain medications?
Answer: Variants in the UGT1A1 gene directly affect drug metabolism, particularly for medications such as irinotecan (chemotherapy) and atazanavir (antiviral). Reduced enzyme activity impairs glucuronidation, elevating the risk of severe toxicity. Pre-treatment genotyping enables personalized dose adjustment, which is especially critical in oncology and long-term antiviral regimens to optimize efficacy and safety.
3. How is the sample collected and what should I expect during the process?
Answer: A certified phlebotomist performs home collection of a venous blood sample or a finger-prick blood spot on an FTA card, with ISO-certified temperature-controlled cold-chain transport to the laboratory. The procedure is minimally invasive and requires no fasting or dietary preparation. Samples are stabilized immediately, and you receive a unique tracking code. Results are delivered through a secure online portal within 3โ4 weeks, followed by a telephonic consultation with a genetic specialist.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and strictly complies with all UAE federal data protection and health information governance frameworks:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): Ensures the lawful collection, processing, and storage of personal and genetic data with explicit patient consent and the right to access, rectify, or erase data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Governs the secure handling of electronic health records, digital diagnostic data, and telemedicine interactions.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Establishes the legal framework for clinical practice standards, informed consent, and patient safety in diagnostic procedures.
All genetic test results are encrypted, access-controlled, and retained strictly per UAE health data retention policies. Patients maintain full ownership of their genetic data with transparent processing protocols.
Clinical & Logistical Metadata
| Test Name | UGT1A1 Gene Crigler-Najjar Syndrome Type 2 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, FTA Card โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM to 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Coding Region Analysis |
| ICD-10-CM Code | E80.5, Z13.228, Z31.5 |
| LOINC Code | 81289-2 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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