Test Price
2,800 AED✅ Home Collection Available
TYK2 Gene Tyrosine Kinase 2 Deficiency Genetic Test in UAE – 2800 AED – DHA Approved
Executive Summary & Core Metrics
Diagnostic Precision: 99.9% sensitivity via NGS with orthogonal confirmation (Sanger/MLPA).
VIP Mobile Phlebotomy: Temperature‑controlled cold‑chain home collection available daily 8 AM–11 PM.
Post‑test Guidance: Telephonic consultation with a consultant medical geneticist.
Insurance Verification: Direct billing check via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TYK2 gene deficiency NGS test screens for pathogenic variants in the TYK2 gene, responsible for autosomal recessive hyper‑IgE syndrome and severe immune dysregulation. This next‑generation sequencing assay provides full coding region coverage with deletion/duplication analysis, delivering a molecular diagnosis within 3–4 weeks. Pre‑test genetic counselling is mandatory to construct a detailed family pedigree for accurate variant classification.
Sample acceptability: Whole blood (EDTA), extracted DNA, or FTA card. All samples must be collected using sterile technique and transported at 2–8°C within 24 hours. VIP Mobile Phlebotomy and temperature‑controlled cold‑chain home collection is available daily from 8 AM to 11 PM via WhatsApp scheduling at +971 54 548 8731.
| Feature | Our Test (DHA Approved) | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity (NGS) | Sanger Sequencing (limited coverage) |
| Methodology | NGS with CNV analysis & LC‑MS/MS verification | Targeted genotyping |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
*PCR‑free NGS library prep, Illumina NovaSeq platform, clinically validated bioinformatics pipeline.
Physician Insight & Safety Protocols
"As a consultant medical geneticist, I emphasize that TYK2 genetic results must be interpreted within the full clinical context and family history. A negative result does not exclude other primary immunodeficiencies. Please discuss your child's immunological history and pedigree with our genetic counsellor before taking any clinical action."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed medication or modify immunosuppressive therapy without consulting your treating physician. All therapeutic adjustments must be supervised by a qualified specialist.
Exclusion Criteria & Emergency Red Flags
- Acute Infection: If the patient has a fever >38°C or active systemic infection, postpone collection until clinically stable.
- Recent Transfusion: Allogeneic blood products within 4 weeks may interfere with DNA purity — reschedule as advised.
- Steroid Burst: High‑dose corticosteroid therapy (>2 mg/kg/day) may transiently alter lymphocyte profiles; document all medications.
- Red Flags (Seek Immediate Care): If the patient develops severe respiratory distress, septic shock signs, or sudden neurological deterioration, proceed to the nearest emergency department regardless of pending test results.
Patient FAQ & Clinical Guidance
1. What is the TYK2 gene test and why is it performed?
The TYK2 gene test identifies mutations linked to tyrosine kinase 2 deficiency for precise clinical diagnosis. This test helps clinicians confirm autosomal recessive hyper‑IgE syndrome, differentiate from other primary immunodeficiencies, and guide targeted therapy. The analysis covers the entire coding region plus exon‑intron boundaries to capture rare variants. Pre‑test genetic counselling is mandatory.
2. How accurate is the TYK2 NGS test?
The DHA‑accredited assay achieves 99.9% diagnostic sensitivity with full validation against reference standards. Our laboratory participates in external quality assessment (EMQN) and uses orthogonal confirmation of all clinically significant variants via Sanger sequencing or MLPA, eliminating false positives.
3. What should I do if my test result is positive?
A positive TYK2 result should be reviewed by a clinical immunologist to tailor long‑term management. Our post‑test telephonic guidance connects you with a specialist who will explain the variant, recommend immunological work‑up, and coordinate family testing if needed. Do not self‑interpret; pathogenic variants rarely alter immediate emergency care.
UAE Regulatory & Data Privacy Adherence
All testing adheres to Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety follow Federal Decree‑Law No. 4 of 2016 on Medical Liability. We are a DHA‑licensed facility (License No. 1143) located at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Direct billing verification is available via WhatsApp at +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | TYK2 Gene Deficiency (Tyrosine Kinase 2) NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next‑Generation Sequencing (NGS) with CNV Analysis and LC‑MS/MS Verification |
| ICD‑10‑CM Code | D82.4 |
| LOINC Code | 101246-5 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 – DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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