Test Price
2,800 AEDโ Home Collection Available
TP63 Gene Rapp-Hodgkin Syndrome Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- 🔬 Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- 🚚 Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- 💉 Clinical Guidance: Telephonic post-test guidance in result interpretation by our DHA-licensed genetic team.
- 💳 Insurance: Direct billing verification via WhatsApp โ +971 54 548 8731.
Test Overview & Methodology
The TP63 Gene Rapp-Hodgkin Syndrome Genetic Test is a definitive diagnostic assay that analyses the entire coding sequence of the TP63 gene using next-generation sequencing (NGS). It identifies pathogenic variants responsible for Rapp-Hodgkin syndrome, a rare ectodermal dysplasia characterised by cleft lip/palate, sparse hair, nail dystrophy, and hypohidrosis. The test is performed on a small blood sample or buccal swab, and results are reported with bioinformatics analysis aligned to the GRCh38 reference genome.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity (full gene NGS) | Conventional Sanger sequencing (targeted analysis) |
| Methodology | Illumina NovaSeqโข Sequencing โ validated bioinformatics pipeline | Conventional Sanger sequencing |
| Turnaround Time | 3โ4 Weeks | 5โ8 Weeks |
| Home Collection | VIP cold-chain phlebotomy included | Often clinic-based only |
Physician Insight & Safety Protocols
โAs a clinical geneticist, I emphasise that a molecular diagnosis of Rapp-Hodgkin syndrome provides clarity for families. This test precisely identifies the underlying TP63 mutation, enabling tailored monitoring for feeding difficulties, hearing loss, and skin infections. Always correlate genetic findings with the full clinical picture; a multi-disciplinary team approach is essential for optimal care.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication and Treatment Continuation
Do not discontinue or modify any prescribed medication or therapy without consulting your treating physician. This genetic test is not a substitute for clinical evaluation and should not prompt self-directed changes in care.
Exclusion Criteria & Emergency Red Flags
- This test is intended for individuals with clinical suspicion of ectodermal dysplasia; it is not offered for asymptomatic screening of minors.
- Sample collection is delayed if the patient has active, severe skin sepsis at the draw site.
- Seek emergency care immediately if the child develops respiratory distress, inability to feed, or signs of hyperthermia (dangerous in anhidrotic forms).
- Results must be reviewed by a qualified geneticist; do not self-interpret raw variant files.
Patient FAQ & Clinical Guidance
1. What is the TP63 gene Rapp-Hodgkin syndrome test and how does it work?
This NGS test screens the entire TP63 gene for mutations causing Rapp-Hodgkin syndrome with 99.9% clinical sensitivity. A small blood sample or buccal swab is collected and analysed by high-throughput sequencing to detect missense, nonsense, and splice-site variants. The bioinformatics pipeline aligns reads to the GRCh38 reference genome, ensuring no pseudogene interference. Results are provided as a comprehensive written report with variant interpretation.
2. Who should consider this genetic test?
Any child or adult with clinical features of ectodermal dysplasia โ such as cleft lip/palate, sparse hair, abnormal nails, and impaired sweating โ should undergo TP63 testing. It is also important for family members of an affected individual to determine carrier status and for expectant parents with a known family history to facilitate prenatal or preimplantation genetic diagnosis. A genetic counselling session is mandatory prior to ordering.
3. How is the sample collected and what are the turnaround times?
A skilled phlebotomist visits your home between 8 AM and 11 PM for a quick blood draw or finger prick; results are delivered within 3โ4 weeks. The sample is immediately placed in a temperature-controlled transport kit and processed in our ISO-certified laboratory. In urgent clinical scenarios, a preliminary verbal report may be discussed with your physician earlier, but the written report follows the standard timeline.
UAE Regulatory & Data Privacy Adherence
โ This service fully complies with the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All samples and results are processed with strict confidentiality in an ISOโaccredited laboratory.
Clinical & Logistical Metadata
| Test Name | TP63 Gene Rapp-Hodgkin Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Buccal Swab; FTA card accepted |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full TP63 Gene Sequencing |
| ICD-10-CM Code | Q82.4 (Ectodermal dysplasia, anhidrotic) |
| LOINC Code | 48018-6 (Gene mutation analysis, targeted sequencing) |
| DHA Facility License & Laboratory Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians