Test Price
2,800 AED✅ Home Collection Available
TP63 Gene ADULT Syndrome & Split Hand-Foot Malformation NGS Genetic Test in UAE
Executive Summary & Core Metrics
- Diagnostic Precision: 99.9% sensitivity for pathogenic TP63 variants via ISO 9001:2015 certified next-generation sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Post-Test Guidance: Complimentary telephonic clinical interpretation session with a Consultant Medical Geneticist.
- Insurance & Billing: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test analyzes the entire coding region of the TP63 gene to detect pathogenic variants responsible for ADULT (Acro-Dermato-Ungual-Lacrimal-Tooth) syndrome and split hand-foot malformation. It is an essential diagnostic and family-planning tool for affected individuals and their relatives.
| Feature | Our Test (NGS Full Gene) | Closest Alternative (Sanger / Small Panel) |
|---|---|---|
| Precision | 99.9% sensitivity for single nucleotide variants, indels, and copy number changes | Limited to targeted hotspots; may miss deep intronic or regulatory variants |
| Methodology | Illumina-based NGS with Sanger validation | Bidirectional Sanger sequencing of selected exons |
| Turnaround Time | 3–4 weeks | Often 6 weeks or longer |
Physician Insight & Safety Protocols
"A pathogenic TP63 variant must always be correlated with the characteristic ectodermal and limb features before confirming the diagnosis. This genetic result is not a standalone verdict — it requires full clinical context and a multidisciplinary care plan. I strongly recommend a dedicated session with a Consultant Medical Geneticist for comprehensive interpretation and family risk assessment."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Important Advisory
Genetic test results provide diagnostic clarity but do not replace ongoing medical management. Continue all prescribed treatments and consult your specialist before making any changes to your care routine.
Safety & Exclusion Criteria
- Not indicated for asymptomatic minors without cardinal clinical signs and prior pediatric geneticist evaluation.
- This test does not replace urgent management for acute blistering, nail bed infections, or severe limb pain — seek immediate care.
- Prenatal diagnosis requires a separate dedicated protocol with specific pre-test counseling; do not use this panel as a prenatal screen.
- If you experience infection, excessive bleeding, or persistent pain at the blood draw site, visit the nearest urgent care facility immediately.
Patient FAQ & Clinical Guidance
1. What is the TP63 gene ADULT syndrome NGS test, and why is it recommended?
This NGS test identifies pathogenic TP63 mutations that cause ADULT syndrome and split hand-foot malformation, enabling accurate diagnosis, prognosis, and informed family planning decisions.
2. How is the sample collected, and what is the turnaround time?
A peripheral whole blood sample or dried blood spot (DBS) on an FTA card is drawn by a DHA-licensed phlebotomist during a VIP home visit. Results are delivered within 3–4 weeks from sample receipt.
3. Is genetic counseling mandatory before and after the test?
Yes, pre-test counseling to document a detailed pedigree is mandatory, and a complimentary post-test telephonic guidance session with a Consultant Medical Geneticist is included with every report.
UAE Regulatory & Data Privacy Adherence
All genetic testing services comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory is ISO 9001:2015 certified and operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | TP63 Gene ADULT Syndrome & Split Hand-Foot Malformation NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood or DBS on FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Validation |
| ICD-10-CM Code | Q71.6, Q87.2 |
| LOINC Code | 94218-3 |
| DHA Facility License & Address | License No: 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians