Test Price
2,800 AED✅ Home Collection Available
TNFRSF1A Gene Periodic Fever (TRAPS) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited processing and dual-validation NGS pipeline.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) for peripheral blood specimens.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance by a DHA-licensed physician to interpret your result in the context of personal and family history.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731 (send your Emirates ID and policy number).
Test Overview & Methodology
The TNFRSF1A gene test by Next-Generation Sequencing (NGS) detects pathogenic variants causing Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS), an autosomal dominant autoinflammatory disorder. This test is performed on a peripheral blood sample, with a turnaround time of 3–4 weeks, confirming clinical suspicion, guiding therapy with IL-1 inhibitors, and screening at-risk family members.
| Feature | Our Test (DNA Labs UAE) | Standard Hospital Panel |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity, full gene coverage (exons + splice sites) via NGS | Sanger sequencing of selected exons; may miss deep intronic or regulatory variants |
| Methodology | Next-Generation Sequencing (NGS) with copy number variation calling | PCR + bidirectional Sanger sequencing |
| Speed | 3–4 weeks (expedited available) | 6–8 weeks |
Physician Insight & Safety Protocols
"A positive TNFRSF1A variant confirms the genetic predisposition to TRAPS, but clinical expression varies widely. I always recommend correlating the result with inflammatory markers (ESR, CRP, SAA) and a detailed fever diary. This test provides immense peace of mind for families with recurrent unexplained fevers, yet it is not a substitute for comprehensive clinical evaluation. Always consult your treating physician before making any changes to your management plan."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Safety
⚠ Important Medication Warning
Do not discontinue prescribed medication (e.g., corticosteroids, biologics) without consulting your doctor. Abrupt cessation can trigger severe inflammatory flares.
Exclusion Criteria & Emergency Red Flags
- This test is not recommended for acute febrile illness with hemodynamic instability—seek immediate ER care.
- Individuals with known bone marrow failure syndromes or active hemophagocytic lymphohistiocytosis (HLH) require specialist clearance before blood draw.
- If you experience chest pain, severe abdominal pain, or altered mental status during a fever episode, proceed to the nearest emergency department immediately.
- Not a stand-alone screening for malignancy; consult an oncologist if fever is accompanied by night sweats, weight loss, or lymphadenopathy.
Patient FAQ & Clinical Guidance
1. What does a positive TNFRSF1A genetic test mean for my health?
A positive result indicates you carry a disease-causing variant in the TNFRSF1A gene, confirming genetic susceptibility to TRAPS. It does not guarantee severe symptoms—periodic fever attacks, migratory rash, and serositis may occur, yet many carriers remain mildly affected. The result must be interpreted alongside your clinical history and inflammatory markers by a specialist.
2. How is the test performed and what sample is needed?
Our trained DHA-licensed phlebotomist collects a small blood sample (3 mL in EDTA tube) from your home after verifying your identity and consent. The NGS process in our ISO-certified lab ensures every nucleotide of the TNFRSF1A gene is read with ultra-high confidence in 3 to 4 weeks.
3. Is this test suitable for children and what are the legal requirements in UAE?
Yes, the test can be performed on minors when clinically indicated, but requires dual parental/guardian consent and a mandatory genetic counseling session before sample collection, as per Federal Decree-Law No. 4 of 2016 on Medical Liability. All personal genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning Use of ICT in Health Fields, stored exclusively on secure servers within the country.
UAE Regulatory & Data Privacy Adherence
Data Protection: Your genetic data is handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All results are encrypted and accessible only to authorized clinicians.
Clinical Safety: Sample collection and processing adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient consent and clinical accountability.
Clinical & Logistical Metadata
| Test Name | TNFRSF1A Gene Periodic Fever (TRAPS) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA tube) – VIP Mobile Phlebotomy & Cold-Chain Home Collection |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV analysis |
| ICD-10-CM Code | M04.1 (Periodic fever syndromes) |
| LOINC Code | 83504-5 (TNFRSF1A gene mutation detection) |
| DHA Facility License & Lab Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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