Test Price
2,800 AED✅ Home Collection Available
TMEM173 (STING) Vasculopathy NGS Genetic Test in Dubai & Abu Dhabi – 2,800 AED
Executive Summary & Core Metrics
Core Metrics & Guarantees
- Diagnostic Accuracy: 99.9% analytical sensitivity for single-nucleotide variants (SNVs) and small insertions/deletions via ISO 9001:2015 accredited NGS platform.
- Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Post-Test Guidance: Telephonic consultation with a DHA-licensed Consultant Medical Geneticist for comprehensive result interpretation.
- Insurance & Billing: Direct billing verification and eligibility confirmation available via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This targeted next-generation sequencing (NGS) test analyzes the entire coding region and conserved exon-intron boundaries of the TMEM173 gene. It is designed to definitively diagnose STING-associated vasculopathy with onset in infancy (SAVI), a rare and severe autoinflammatory condition characterized by early-onset systemic inflammation, cutaneous vasculitis, and interstitial lung disease. Accurate molecular diagnosis is critical for initiating targeted immunomodulatory therapy and avoiding irreversible organ damage.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% analytical sensitivity for SNVs & small indels, plus copy number variant (CNV) calling | High per-amplicon accuracy but restricted to coding exons; may miss deep intronic variants or large deletions |
| Methodology | Illumina® NextSeq with dual-indexed libraries, advanced bioinformatics pipeline with CNV detection | Bidirectional Sanger sequencing of coding exons only |
| Turnaround Time | 3 – 4 weeks | 6 – 8 weeks |
Physician Insight & Safety Protocols
“A molecular confirmation of SAVI through comprehensive TMEM173 sequencing is a pivotal step in the diagnostic odyssey for these complex patients. It is imperative that the genetic findings are correlated with the clinical phenotype and family pedigree within a multidisciplinary setting, typically involving pediatric rheumatology, immunology, and clinical genetics, to guide precise therapeutic intervention.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA ID: 9294403
⚠️ Medication and Clinical Advisory
Do not discontinue prescribed medication without consulting your doctor. This test provides diagnostic information and does not replace continuous clinical management. Any therapeutic changes must be directed exclusively by the treating physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to obtain legally valid informed consent from the patient or legal guardian.
- Exclusion: Unwillingness or inability to complete mandatory pre-test genetic counseling as mandated by Federal Law No. 2 of 2019.
- Emergency Red Flags: Presentation of acute fever, unexplained extensive purpuric rash, severe arthralgia with swelling, or acute respiratory distress warrants immediate emergency medical intervention. These symptoms may indicate a severe inflammatory flare requiring urgent treatment.
Patient FAQ & Clinical Guidance
1. What is the TMEM173 (STING) gene test used for?
This NGS-based genetic test is used to diagnose STING-associated vasculopathy with onset in infancy (SAVI). It detects pathogenic mutations in the TMEM173 gene, confirming the diagnosis in patients with unexplained early-onset systemic inflammation, skin vasculitis, and interstitial lung disease, thereby guiding targeted treatment decisions.
2. How should I prepare for the TMEM173 genetic test?
Preparation involves a mandatory pre-test genetic counseling session to review the family pedigree and obtain informed consent. No specific fasting or medication adjustments are required unless explicitly directed by your physician. Our mobile phlebotomist can collect a blood sample at your home between 8 AM and 11 PM.
3. Does my health insurance cover the cost of this genetic analysis?
We conduct direct insurance eligibility verification via WhatsApp at +971 54 548 8731 prior to scheduling your appointment. Coverage is dependent on your specific policy and the medical necessity determined by your referring physician. Flexible self-pay options are available for patients without insurance coverage.
UAE Regulatory & Data Privacy Adherence
Your Trust and Data Security Framework
DNA Labs UAE strictly adheres to the highest standards of medical data protection and clinical safety as mandated by UAE federal laws.
- Data Privacy: Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety & Consent: All procedures are conducted in line with Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety, rights, and informed consent.
- Accreditation: Our NGS laboratory is ISO 9001:2015 accredited, ensuring rigorous quality control and diagnostic reliability.
Clinical & Logistical Metadata
| Test Name | TMEM173 (STING) Vasculopathy NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina® NextSeq Platform |
| ICD-10-CM Code | M35.8 (Other specified systemic involvement of connective tissue) |
| LOINC Code | 91856-0 (STING associated vasculopathy with onset in infancy [SAVI] gene mutation analysis) |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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