Test Price
2,800 AED✅ Home Collection Available
STX1B Gene Generalized Epilepsy with Febrile Seizures Plus Type 9 Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited next‑generation sequencing (NGS) processing.
- Premium Logistics: VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Post‑test telephonic consultation for result interpretation and personalized management planning.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
- Price: 2800 AED (all‑inclusive, no hidden charges).
Test Overview & Methodology
This next‑generation sequencing (NGS) test investigates the entire coding region and flanking intronic boundaries of the STX1B gene to detect pathogenic variants linked to generalized epilepsy with febrile seizures plus (GEFS+) type 9. The analysis provides high‑resolution detection of single‑nucleotide variants and small insertions/deletions, enabling a definitive molecular diagnosis for individuals and families with this autosomal dominant epilepsy syndrome.
| Feature | Our Test – STX1B NGS | Closest Alternative – GEFS+ Gene Panel |
|---|---|---|
| Methodology | Full STX1B gene sequencing by Next‑Generation Sequencing (NGS) | Targeted Sanger sequencing or multi‑gene panel including STX1B + SCN1A, SCN1B, GABRG2 |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks (panel dependent) |
| Coverage | 100% coding exons ±10 bp flanking intronic regions of STX1B | Limited to known hot‑spots or incomplete coverage of STX1B |
| Clinical Sensitivity | 99.9% for single‑nucleotide variants and indels | ~95% for Sanger; panel sensitivity varies |
| Price | 2800 AED | From 3500 AED (Sanger); ~5000 AED (full panel) |
Physician Insight & Safety Protocols
– Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed anti‑epileptic medication without consulting your doctor. Abrupt withdrawal can provoke seizure emergencies. Always maintain medication adherence unless specifically advised by your treating physician.
Safety Exclusion Criteria & ER Red Flags
- Exclusion Criteria: Home collection is postponed if the patient is in status epilepticus, has hemodynamic instability, or requires emergency medical intervention.
- Emergency Red Flags: Seek immediate emergency care if you experience prolonged (≥5 minutes) seizure, clustering seizures without return to baseline, altered consciousness, or respiratory distress.
Patient FAQ & Clinical Guidance
1. What does a positive STX1B test mean for my epilepsy management?
A positive result identifies a disease‑causing variant in the STX1B gene, confirming a genetic form of generalized epilepsy with febrile seizures plus. However, the test alone cannot forecast seizure frequency or drug response. A positive finding should be interpreted alongside electroclinical history and may guide antiseizure medication selection (e.g., avoiding sodium channel blockers) and inform family genetic counselling.
2. Is genetic counselling mandatory before this test?
Yes, pre‑test genetic counselling is strongly recommended to draw a comprehensive family pedigree, explain potential outcomes (including incidental findings), and discuss implications for relatives. This aligns with international best practice and UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability, ensuring informed consent and patient understanding.
3. How is the sample collected, and do I need to fast or adjust medications?
A venous blood sample (or an FTA card finger‑prick as an alternative) is collected by a certified phlebotomist at your home. No fasting is required, and you should continue all prescribed medications without interruption unless specifically instructed by your doctor. The collection window is 8 AM to 11 PM, seven days a week.
4. What are the expected turnaround times, and how will I receive my report?
The standard turnaround time is 3 to 4 weeks from sample collection. Reports are delivered electronically via secure patient portal and are also available by email or courier upon request. Our genetic counsellor will contact you after result availability to offer a telephonic explanation of the report.
5. Does this test cover all known epilepsy genes?
No, this is a single‑gene test limited to the STX1B gene. If your clinical presentation suggests a broader genetic epilepsy panel, our medical geneticist may recommend a multi‑gene panel or whole‑exome sequencing. The decision should be guided by pre‑test counselling and clinical evaluation.
UAE Regulatory & Data Privacy Adherence
Compliance Framework: This test is performed in full conformity with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring your health data is processed, stored, and transferred with strict confidentiality and consent.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing digital health records and tele‑medicine interactions.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – outlining physician responsibilities, informed consent, and patient safety standards.
All genetic data is handled under explicit patient consent and is never shared without authorization. DNA Labs UAE is an ISO 9001:2015 certified facility (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License Number 1143.
Clinical & Logistical Metadata
| Test Name | STX1B Gene Sequencing – Generalized Epilepsy with Febrile Seizures Plus Type 9 |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole blood (EDTA) or FTA card finger‑prick |
| Methodology Used | Next‑Generation Sequencing (NGS) – whole gene analysis |
| ICD-10-CM Code | G40.3 (Generalized idiopathic epilepsy and epileptic syndromes) / R56.0 (Febrile convulsions) |
| LOINC Code | 85443-8 (Genetic testing for epilepsy related gene mutation) |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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