Test Price
2,800 AED✅ Home Collection Available
SRPX2 Gene DNA Test for Rolandic Epilepsy, Intellectual Disability & Speech Dyspraxia in Dubai | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in Result Interpretation by DHA-licensed professionals.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
This diagnostic assay delivers definitive molecular confirmation of SRPX2-related disorders, enabling precise therapeutic planning and accurate recurrence risk assessment for affected families.
Test Overview & Methodology
The SRPX2 Gene NGS Test uses Next-Generation Sequencing to detect pathogenic variants in the SRPX2 gene responsible for Rolandic epilepsy, intellectual disability, and speech dyspraxia. This test provides a definitive molecular diagnosis, guiding neurologists in personalized management and familial risk assessment.
| Feature | Our SRPX2 NGS Test | Standard Single-Gene Screening |
|---|---|---|
| Precision | 99.9% sensitivity (full gene coding region) | ~85% sensitivity; may miss rare variants |
| Methodology | NGS (Next-Generation Sequencing) with bioinformatic validation | PCR-based targeted mutation panels |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Clinical Utility | Comprehensive detection of known & novel variants; family counselling | Limited to pre-defined common mutations |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I emphasise that the SRPX2 gene test serves as a critical diagnostic anchor for patients presenting with rolandic epilepsy, developmental delay, and motor speech deficits. The NGS platform offers broad coverage of coding and splice-region variants that would escape conventional PCR approaches. However, a negative result does not eliminate other genetic epilepsies or acquired causes. Correlation with clinical phenotype, neuroimaging, and EEG patterns remains essential. I recommend pre-test genetic counselling to discuss potential secondary findings and implications for at-risk first-degree relatives.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Pre-Test Genetic Counselling Required
All patients must complete a formal genetic counselling session prior to sample collection. The counsellor will review the familial pedigree, discuss the possibility of secondary findings in other genes, and explain the implications of variant classification (pathogenic, likely pathogenic, variant of uncertain significance). This step is mandated under Federal Decree-Law No. 4 of 2016 on Medical Liability to ensure informed consent and shared decision-making.
Exclusion Criteria & Urgent Clinical Indicators
- The test is not suitable for individuals unable to provide independent informed consent or those with acute neuropsychiatric decompensation contraindicating a blood draw.
- ER Alert: Seek immediate medical attention if seizure frequency abruptly escalates, a seizure persists beyond five minutes (status epilepticus), consciousness is lost, or a severe allergic reaction occurs post-phlebotomy.
- Results are intended for non-emergency diagnostic use; acute neurological deterioration requires prompt in-person clinical evaluation.
Patient FAQ & Clinical Guidance
1. What is the SRPX2 gene test used for?
This test identifies pathogenic variants in the SRPX2 gene that cause Rolandic epilepsy, intellectual disability, and speech dyspraxia. It provides a molecular confirmation that guides treatment decisions, enables accurate recurrence risk assessment, and allows cascade screening of at-risk family members.
2. How should I prepare for the test, and what sample is required?
No special preparation is needed. The laboratory accepts peripheral whole blood, dried blood spot, or extracted DNA. A pre-test genetic counselling session is strongly recommended to document the family pedigree and discuss potential findings. Do not discontinue any antiepileptic medications without consulting your treating neurologist.
3. How long does it take to get results, and how will they be delivered?
The turnaround time is 3–4 weeks from sample receipt. Results are delivered through a secure patient portal and a telephonic consultation with a DHA-licensed clinical geneticist who explains the findings, their clinical significance, and recommended next steps.
4. Is my genetic data protected under UAE law?
Absolutely. Your genomic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All samples are processed in ISO-certified laboratories with strict access controls. No genetic information is shared without your explicit written consent.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the regulatory oversight of the Dubai Health Authority (DHA Facility License No. 1143). All genetic testing procedures comply with the following UAE federal laws:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing confidentiality, consent, and data subject rights for all personal and genomic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – establishing standards for electronic health records, data security, and telehealth practices.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – defining obligations for informed consent, clinical safety, and professional accountability in diagnostic procedures.
All samples are processed in ISO 9001:2015 accredited laboratories with encrypted data transmission and role-based access controls to ensure end-to-end privacy.
Clinical & Logistical Metadata
| Test Name | SRPX2 Gene DNA Test for Rolandic Epilepsy, Intellectual Disability & Speech Dyspraxia (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood, Dried Blood Spot (DBS), or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – Whole Gene Coding Region & Splice Sites |
| ICD-10-CM Code | Z13.71 (Encounter for genetic testing), G40.0 (Rolandic epilepsy), F70 (Mild intellectual disability), R48.2 (Apraxia of speech) |
| LOINC Code | 51955-5 (Gene mutations found in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians