Test Price
2,800 AED✅ Home Collection Available
SOX18 Gene Hypotrichosis‑Lymphedema‑Telangiectasia Syndrome Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance by a DHA-licensed genetic counsellor.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next‑generation sequencing (NGS) test comprehensively analyses the entire coding region of the SOX18 gene to diagnose Hypotrichosis‑Lymphedema‑Telangiectasia Syndrome (HLTS) with laboratory precision.
| Feature | Our Test (NGS – HLTS Panel) | Closest Alternative (Single‑gene Sanger) |
|---|---|---|
| Methodology | NGS – high‑depth capture & sequencing of entire SOX18 gene | Sanger sequencing of selected exons only |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Detection Coverage | Exon‑level deletions, duplications, splice‑site & deep intronic variants | Limited to previously described hotspot regions |
| Pre‑test Genetic Counselling | Mandatory – included in service | Often optional or external |
| Price (AED) | 2,800 | 2,200 – 3,000 |
| Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Varies |
Physician Insight & Safety Protocols
“Identifying a pathogenic variant in the SOX18 gene provides definitive confirmation of HLTS and enables accurate recurrence risk counselling for families. However, it must be emphasized that a negative sequencing result does not exclude all genetic or acquired phenocopies. Correlation with dermatological and immunological assessments is essential before finalizing the diagnosis. I strongly recommend that patients review their results with a clinical geneticist to fully understand the implications for future medical management and family planning.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory
Do not discontinue any prescribed medication without consulting your doctor. This genetic test does not replace ongoing clinical care.
Safety & Exclusion Criteria
- Exclusion criteria: Inability to provide informed consent (or legal guardian consent for minors as per Federal Decree-Law No. 4 of 2016 on Medical Liability), severe anaemia (Hb <7 g/dL), uncontrolled bleeding disorder, active infection at venipuncture site.
- ER red flags after sample collection: Sudden severe swelling or pain at needle site, difficulty breathing, fainting, or signs of infection (redness, heat, pus). Seek immediate medical attention.
- All home‑collection phlebotomists carry emergency kits and are trained in first response.
Patient FAQ & Clinical Guidance
1. What exactly does this SOX18 NGS test detect?
This Next‑Generation Sequencing test identifies pathogenic variants throughout the entire SOX18 gene, confirming the clinical diagnosis of hypotrichosis‑lymphedema‑telangiectasia syndrome with 99.9% sensitivity. It can detect single‑nucleotide variants, small insertions/deletions, and exon‑level copy number changes.
2. Who should consider this genetic test?
Individuals presenting with clinical features such as congenital hypotrichosis, early‑onset lymphedema, and telangiectasias, or those with a family history of HLTS, should consider testing to confirm the diagnosis and guide management. Pre‑test genetic counselling is mandatory to ensure informed consent.
3. Is genetic counselling mandatory before the test?
Yes, a pre‑test genetic counselling session is mandatory. It includes drawing a detailed three‑generation family pedigree, explaining all possible outcomes (positive, negative, or variant of uncertain significance), and obtaining written informed consent before sample collection.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, anonymized, and handled under strict confidentiality protocols. Our facility is DHA licensed (No. 1143) and ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | SOX18 Gene Hypotrichosis‑Lymphedema‑Telangiectasia Syndrome Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) – Whole gene sequencing of SOX18 |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 88550-6 |
| DHA Facility License & Lab Address | License No. 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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