Test Price
2,800 AED✅ Home Collection Available
SLC25A38 Gene Pyridoxine-Refractory Sideroblastic Anemia Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy – Available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed genetics specialist.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This advanced NGS (Next-Generation Sequencing) test analyzes the entire coding region of the SLC25A38 gene to detect mutations responsible for autosomal recessive pyridoxine-refractory sideroblastic anemia. The test employs targeted enrichment with high-depth coverage to identify pathogenic variants, including single nucleotide variants, small insertions, and deletions across all exons and flanking intronic regions.
| Feature | Our Test (SLC25A38 NGS) | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Methodology | Targeted NGS with high-depth coverage | Broad exome capture, lower depth per gene |
| Precision | 99.9% analytical sensitivity for target gene | ~95% sensitivity, may miss deep intronic variants |
| Turnaround Time | 3 to 4 Weeks | 6 to 10 Weeks |
| Cost (AED) | 2,800 | 4,500 – 7,000 |
Physician Insight & Safety Protocols
This section provides expert clinical context, safety advisories, and exclusion criteria to ensure informed decision-making before proceeding with the SLC25A38 genetic test.
Insight from Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403): “As a consultant medical geneticist specializing in inherited hematological disorders, I recognize the profound impact a confirmed molecular diagnosis can have on clinical management. The SLC25A38 gene test provides definitive evidence for pyridoxine-refractory sideroblastic anemia, but it is critical that these results are interpreted alongside the complete blood count, iron metabolism studies, peripheral blood smear, and detailed family pedigree. Molecular confirmation alone does not replace a comprehensive clinical evaluation. Always consult a qualified genetic counselor to discuss implications for family members and reproductive planning.”
Safety Advisory & Important Precautions
Do not discontinue any prescribed medication, including pyridoxine or other hematinic agents, solely based on genetic test results. Continue all treatments under direct medical supervision. If you experience severe symptoms such as extreme fatigue, pallor, chest pain, or shortness of breath, seek immediate emergency care and postpone elective genetic testing.
Exclusion Criteria & Testing Requirements
- This test is not a standalone screening tool; a referral from a physician or genetic counselor is mandatory for test initiation.
- Insufficient sample quality, including clotted blood specimens or improperly dried FTA cards, may require recollection at an additional cost.
- Patients undergoing active blood transfusion within the past 7 days should inform the laboratory, as transfused donor DNA may interfere with interpretation.
Patient FAQ & Clinical Guidance
1. What is the SLC25A38 gene test and why is it important?
This targeted NGS test detects pathogenic mutations in the SLC25A38 gene, which causes autosomal recessive pyridoxine-refractory sideroblastic anemia. Accurate genetic diagnosis enables precise clinical management, including iron chelation therapy, avoidance of unnecessary treatments, and informed family counseling regarding recurrence risks.
2. What sample type is required and how is it collected?
The preferred specimen is 3-5 mL of peripheral whole blood collected in an EDTA tube. Alternatively, extracted genomic DNA or a dried blood spot on an FTA card is acceptable. Our VIP Mobile Phlebotomy service provides temperature-controlled cold-chain home collection daily from 8 AM to 11 PM across Dubai and all UAE emirates.
3. How long do results take and how will I understand them?
The standard turnaround time is 3 to 4 weeks from sample receipt. All results include a mandatory telephonic post-test clinical guidance session with a DHA-licensed genetics specialist who will explain the report, discuss variant classifications, and outline recommended follow-up steps.
4. Is the test covered by insurance in the UAE?
Coverage depends on your specific insurance policy and provider. We offer direct billing verification for select plans. Please send a copy of your insurance card via WhatsApp at +971 54 548 8731 to confirm eligibility before booking the test.
UAE Regulatory & Data Privacy Adherence
Compliance Framework & Patient Data Protection
DNA Labs UAE operates under DHA Facility License Number 1143 and strictly adheres to the following UAE federal laws governing clinical laboratory operations and patient data security:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): Ensures all genetic and personal data are collected, stored, and processed with explicit patient consent, data minimization, and robust encryption protocols.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Mandates secure electronic health information exchange, audit trails, and strict access controls to protect patient confidentiality.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Governs informed consent procedures, clinical safety standards, and professional accountability in diagnostic testing.
All genetic test results are released only to the ordering physician and the patient via a secure password-protected portal or encrypted email. No third-party sharing occurs without prior written authorization.
Clinical & Logistical Metadata
| Test Name | SLC25A38 Gene Pyridoxine-Refractory Sideroblastic Anemia Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) with high-depth coverage of all coding exons and flanking intronic regions of the SLC25A38 gene |
| ICD-10-CM Code | D64.0 |
| LOINC Code | 81369-6 |
| DHA Facility License & Laboratory Address Invariants | DHA Facility License Number: 1143 | Physical Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab Branding: DNA Labs UAE |
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