Test Price
2,800 AED✅ Home Collection Available
SLC25A1 Gene Combined D-2- and L-2-Hydroxyglutaric Aciduria Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
Clinical Confidence, Delivered to Your Door
This NGS-based genetic test detects pathogenic variants in the SLC25A1 gene, confirming a diagnosis of combined D-2- and L-2-hydroxyglutaric aciduria with 99.9% diagnostic sensitivity. The test is performed in an ISO 9001:2015 certified laboratory (Cert: INT/EGQ/2509DA/3139) under strict quality controls.
9001:2015
Certified
Test Overview & Methodology
The SLC25A1 gene test utilizes Next-Generation Sequencing (NGS) to analyze the entire coding region and splice sites of the SLC25A1 gene. This provides single-nucleotide resolution and full gene coverage, enabling definitive molecular diagnosis of combined D-2- and L-2-hydroxyglutaric aciduria. The test is indicated for symptomatic patients with clinical suspicion of a neurometabolic disorder and for at-risk family members.
| Feature | Our Test (NGS Panel) | Alternative: Urine Organic Acid Profiling |
|---|---|---|
| Precision | Single-nucleotide resolution, full gene coverage | Biochemical levels, may miss mild cases |
| Methodology | NGS (Illumina), 100x depth, whole gene sequencing | GC-MS / LC-MS |
| Turnaround Time | 3–4 Weeks | 7–10 Days |
| Clinical Actionability | Definitive diagnosis & family cascade screening | Screening only; requires genetic confirmation |
Physician Insight & Safety Protocols
A Note from Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
“As a clinical geneticist, I understand the profound significance a precise genetic diagnosis carries for families navigating a rare metabolic disorder. This NGS test provides definitive molecular confirmation, empowering early intervention, accurate recurrence risk counselling, and informed reproductive planning. However, every finding must be correlated with the full clinical phenotype and biochemical data; a genetic result is never interpreted in isolation.”
Advisory Notice
⚠️ Medication & Safety Warning
Do not discontinue prescribed medications or initiate new supplements based solely on this test result without consulting your treating physician. This test is designed for diagnostic confirmation and family risk assessment, not for acute management decisions.
Exclusion Criteria
- Asymptomatic individuals without a family history of hydroxyglutaric aciduria or prior genetic counselling are not eligible for direct-to-consumer ordering. Physician referral is required.
- Emergency red flags: If you or your child experience sudden neurological decline, seizures, or loss of consciousness, seek emergency care immediately. This test is not for acute management.
Patient FAQ & Clinical Guidance
1. What is the SLC25A1 gene test used for?
This DNA test identifies pathogenic variants in the SLC25A1 gene, confirming a diagnosis of combined D-2- and L-2-hydroxyglutaric aciduria in symptomatic individuals and at-risk family members. It also enables carrier testing and prenatal planning.
2. How is the sample collected and how long does it take?
A DHA-licensed phlebotomist will visit your home for a simple blood draw (EDTA tube) or saliva collection. Results are ready in 3 to 4 weeks from sample receipt.
3. What happens after I receive my genetic result?
A board-certified genetic counsellor will contact you to explain the findings, discuss clinical implications, and coordinate specialist referrals for metabolic and neurological management if indicated.
4. Is pre-test genetic counselling mandatory?
Yes. Informed consent is required, and we provide pre-test counselling via telephonic consultation to ensure you understand the scope, limitations, and possible outcomes of the test.
UAE Regulatory & Data Privacy Adherence
Data Protection & Clinical Governance
Your genomic data is processed in accordance with the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing follows Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent. The laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and operates under DHA facility license number 1143.
This test is provided by DNA Labs UAE, located at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Patient data is never shared without explicit consent and is stored in secured, access-controlled servers.
Clinical & Logistical Metadata
| Test Name | SLC25A1 Gene Combined D-2- and L-2-Hydroxyglutaric Aciduria Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Blood (EDTA) or Saliva (Oragene DNA kit) |
| Methodology Used | Next-Generation Sequencing (NGS) – Whole gene sequencing with 100x depth, Illumina platform |
| ICD-10-CM Code | E72.89 |
| LOINC Code | 81319-4 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians