Test Price
2,800 AED✅ Home Collection Available
SFXN4 Gene Combined Oxidative Phosphorylation Deficiency Type 18 Genetic Test in UAE | 2800 AED | Accredited by DHA
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited Processing. Premium Logistics: Hospital‑Grade Home Collection with Certified Cold‑Chain & VIP Mobile Phlebotomy. Clinical Guidance: Telephonic Post‑Test Clinical Discussion. Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This single‑gene NGS test analyses the entire coding region of SFXN4 to confirm or exclude biallelic pathogenic variants causing Combined Oxidative Phosphorylation Deficiency Type 18, a severe mitochondrial disorder. The assay is optimized for UAE ordering clinicians, providing a definitive diagnosis in 3–4 weeks with pre‑ and post‑test genetic counselling integration.
| Feature | Our SFXN4 NGS Test (Gold Standard) | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | Targeted full SFXN4 coverage with >99% analytical sensitivity & specificity | Moderate depth; may miss deep intronic or copy‑number variants |
| Method | Clinical‑grade NGS with orthogonal Sanger confirmation of all pathogenic variants | Broad genomic sweep with incidental findings and complex variant interpretation |
| Speed | 3–4 weeks from sample arrival | Often 8–12 weeks |
| Cost (AED) | 2,800 | 3,500 – 5,000 |
Physician Insight & Safety Protocols
"As a genetic specialist, I recognize the profound impact a definitive molecular diagnosis can have on patient care. This targeted SFXN4 test offers exceptional precision for confirming Combined Oxidative Phosphorylation Deficiency Type 18. However, results must always be contextualized within the full clinical picture, including neurological exams and family history. Genetic data is a powerful tool, not an isolated answer."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Safety Precautions
- Clinical Oversight Required: This test must be ordered by a qualified physician after appropriate clinical evaluation.
- Genetic Counselling: Pre-test counselling is mandatory to discuss implications for management, family planning, and insurance.
- Medication Continuity: Continue all prescribed medications unless directed otherwise by your physician; no known drug interference with this test.
Clinical Exclusion Criteria
- Informed Consent: Adults must provide written consent; for minors, consent from a legal guardian is required per Federal Decree-Law No. 4 of 2016 on Medical Liability. Individuals with impaired decision-making capacity cannot be tested without a legally authorized representative.
- Coagulopathy or Recent Transfusion: Severe bleeding disorders or blood transfusion within 4 weeks may compromise DNA integrity; physician clearance required before collection.
- Medication Warning: Do not discontinue any prescribed medication without consulting your treating physician. No routine supplements interfere with the test.
- Emergency Red Flags: If you experience new or worsening seizures, loss of consciousness, acute muscle weakness, or respiratory distress, seek immediate emergency care before scheduled collection.
Patient FAQ & Clinical Guidance
1. How is the SFXN4 NGS test performed and what sample is required?
We accept a simple blood sample (5 ml in EDTA tube), extracted DNA, or a single blood drop on an FTA card. The sample is processed using next‑generation sequencing that reads the entire SFXN4 gene with >99% coverage, and any variant found is confirmed by the gold‑standard Sanger method to ensure 100% accuracy. No fasting is necessary unless additional metabolic tests are ordered.
2. What does a positive result mean and who should order this test?
A positive result means two disease‑causing mutations (one from each parent) were identified, confirming the diagnosis of Combined Oxidative Phosphorylation Deficiency Type 18. This should be ordered by a general physician, clinical geneticist, or dietitian after a detailed clinical history and pedigree chart. Genetic counselling is mandatory before testing to help you understand the implications for symptom management, family risk, and reproductive options.
3. How does UAE law protect my genetic data and insurance coverage?
Your genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring full confidentiality. We process all samples in our ISO 9001:2015 accredited facility with encrypted reporting. While many UAE insurers cover medically necessary genetic tests, we offer direct billing verification via WhatsApp at +971 54 548 8731 to confirm your coverage. No data is shared with third parties without your explicit, documented consent.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Security
DNA Labs UAE operates under DHA Facility License No. 1143 and strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access is logged, and results are shared only with the ordering physician and patient upon explicit consent. You have the right to request data access, correction, or deletion as per applicable law.
Clinical & Logistical Metadata
| Test Name | SFXN4 Gene Combined Oxidative Phosphorylation Deficiency Type 18 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral blood (EDTA tube), extracted DNA, or FTA card. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM–11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation of pathogenic variants |
| ICD-10-CM Code | E88.49 |
| LOINC Code | 48768-0 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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