Test Price
2,800 AED✅ Home Collection Available
SERPINE1 Gene (Plasminogen Activator Inhibitor Type 1) Genetic Test in UAE | 2,800 AED | DHA Licensed Facility
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Next-Generation Sequencing (NGS).
- ✓ Premium Logistics: Hospital-Grade Home Collection with ISO-Certified Cold Chain, VIP Mobile Phlebotomy (8 AM – 11 PM).
- ✓ Clinical Guidance: Telephonic Post-Test Result Interpretation by DHA-Licensed Genetic Counsellors.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
Direct Billing available with major UAE insurers. Terms apply.
Test Overview & Methodology
This next-generation sequencing (NGS) test analyzes the entire coding region of the SERPINE1 gene, which encodes plasminogen activator inhibitor-1 (PAI-1), a key regulator of fibrinolysis and vascular health. It identifies pathogenic variants associated with thrombotic and vascular disorders, enabling early risk stratification and personalized prevention strategies. The test utilizes Illumina NGS with proprietary bioinformatics pipelines, aligned against reference genome GRCh38, with all clinically significant findings confirmed via Sanger sequencing.
| Feature | Our SERPINE1 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Precision | >99.9% analytical sensitivity; complete exon coverage | ~98% per amplicon; may miss deep intronic variants |
| Methodology | Illumina NGS with proprietary bioinformatics, confirmed by Sanger validation | Single-gene capillary electrophoresis |
| Turnaround Time | 21–28 working days (with genetic counselling report) | 15–20 working days (limited interpretation) |
Physician Insight & Safety Protocols
“A focused genetic evaluation of the SERPINE1 gene offers a precise window into an individual's innate fibrinolytic potential. As a Consultant Medical Geneticist, I interpret these variants strictly within the context of the patient's personal and family thrombotic history. A finding of a pathogenic variant does not dictate imminent disease, but rather provides an opportunity for nuanced, evidence-based risk mitigation. It is mandatory that these results are discussed during a formal genetic counselling session before any clinical decisions are made.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
⚠ Important Medication Warning
Do not discontinue, alter, or adjust any prescribed antithrombotic, anticoagulant, or hormone therapy based on this genetic test result without explicit consultation with your treating physician. Abrupt cessation of these therapies can precipitate fatal thromboembolic events. This genetic information is designed to inform long-term risk stratification, not to guide acute medication changes.
Patient Exclusion & Emergency Criteria
- Acute Thrombosis or Uncontrolled Bleeding: Postpone collection if the patient has experienced an acute thrombotic event or uncontrolled bleeding episode within the last 4 weeks.
- Bone Marrow Transplant Recipients: Known bone marrow transplant within the last 6 months may lead to donor DNA interference. Inform the laboratory prior to collection.
- Emergency Red Flags: Sudden severe chest pain, unexplained hemoptysis, acute limb swelling, or neurological deficits require immediate Emergency Room evaluation and should not be delayed for a scheduled genetic test.
Patient FAQ & Clinical Guidance
1. How does this NGS test detect SERPINE1-related vascular risk?
Our clinical-grade NGS panel fully sequences the SERPINE1 gene, including all exons and intronic boundaries, to identify single nucleotide variants, small insertions/deletions, and copy number changes. The bioinformatics analysis classifies variants according to ACMG/AMP guidelines. The test achieves 99.9% sensitivity and specificity for detecting clinically reportable variants associated with thrombophilia and altered fibrinolytic activity.
2. Is home sample collection truly sterile and reliable for genetic testing?
Yes, our DHA-licensed phlebotomists utilize ISO-certified venipuncture protocols and temperature-controlled cold-chain transport kits (2–8°C). Blood drawn in EDTA tubes or collected on DNA FTA cards is stabilized immediately and transported directly to our central laboratory. Sample viability and DNA integrity are confirmed via spectrophotometry and gel electrophoresis before the NGS workflow begins.
3. What happens after I receive my SERPINE1 genetic report?
A comprehensive genetic counselling teleconsultation is scheduled with a DHA-licensed genetic counsellor. During this session, the clinical significance of your results, potential lifestyle modifications, serial D-dimer monitoring plans, and prophylactic strategies will be discussed. A copy of the report is shared with your primary physician to ensure coordinated and informed follow-up care.
UAE Regulatory & Data Privacy Adherence
📜 Strict Compliance with UAE Federal Laws
- Data Privacy: Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Data Governance: Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability: Clinical protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability for patient safety and informed consent.
- Certification: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | SERPINE1 Gene (PAI-1) Sequencing |
| Price (AED) | 2,800 |
| Turnaround Time | 21–28 Working Days |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or DNA FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Z15.89, D68.59, I82.401 |
| LOINC Code | 83019-5 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
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All reports reviewed by DHA-Certified physicians