Test Price
2,800 AED✅ Home Collection Available
SEC23B Gene CDAN2 (Congenital Dyserythropoietic Anemia Type II) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SEC23B لأنيميا تكون الكريات الحمر الخلقية من النوع الثاني (CDAN2) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
فحص جيني شامل لتحديد الطفرات المرضية في جين SEC23B المرتبط بأنيميا تكون الكريات الحمر الخلقية من النوع الثاني (CDA Type II) باستخدام تقنية التسلسل الجيني من الجيل التالي (NGS). دقة تشخيصية تصل إلى 99.9% عبر مختبر حاصل على شهادة الآيزو 9001:2015 ومعتمد من هيئة الصحة بدبي.
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- ✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy (8 AM – 11 PM, all Emirates).
- ✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation with DHA-Licensed specialists.
- ✓ Insurance: Direct Billing Verification via WhatsApp: +971 54 548 8731.
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Overview
The SEC23B Gene CDAN2 Genetic Test is a definitive molecular diagnostic tool that sequences the entire SEC23B gene using Next Generation Sequencing (NGS) to detect pathogenic variants responsible for Congenital Dyserythropoietic Anemia Type II (CDA II) — a rare autosomal recessive hematological disorder marked by ineffective erythropoiesis, jaundice, splenomegaly, and progressive iron overload.
This test is essential for patients presenting with unexplained chronic anemia, abnormal red blood cell morphology on peripheral smear, and a suspected hereditary hemolytic condition. It is also indicated for at-risk family members seeking carrier screening and for couples planning pregnancy who wish to assess reproductive risk.
| Feature | Our SEC23B NGS Test (DHA-Accredited) | Closest Alternative (Targeted Panel / Sanger) |
|---|---|---|
| Diagnostic Sensitivity | 99.9% – Full gene coverage including deep intronic regions | ~85% – Limited to pre-selected known mutations only |
| Methodology | NGS (Next Generation Sequencing) at 1000x depth of coverage | Sanger Sequencing or Targeted Genotyping (limited loci) |
| Turnaround Time | 3 to 4 Weeks – Comprehensive bioinformatics analysis included | 2 to 3 Weeks – Limited bioinformatics pipeline |
| Clinical Utility | Complete – Novel variant discovery enabled | Partial – Misses rare or novel pathogenic variants |
| ISO Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Variable – Often unaccredited |
Physician Insight & Safety Protocol
Dr. Prabhakar Reddy — DHA License No. 61713011, Consultant Hematologist
"Understanding your genetic makeup is a deeply personal journey. While the SEC23B gene test provides critical molecular insights into Congenital Dyserythropoietic Anemia Type II, it must be interpreted within the full context of your clinical history, complete blood count parameters, peripheral blood smear findings, and a detailed family pedigree. I strongly recommend a pre-test genetic counselling session to ensure you fully comprehend the implications for your health, your children, and your extended family."
⚠️ CLINICAL NOTICE: Do not discontinue any prescribed medication, including iron chelators, folic acid supplements, or blood transfusion schedules, without consulting your treating physician. Genetic test results are diagnostic adjuncts — not replacements for ongoing clinical management.
! Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed Without Physician Clearance):
- Active acute hemolytic crisis requiring emergency transfusion
- Recent blood transfusion within 14 days (may interfere with DNA extraction from whole blood; use buccal swab or FTA card alternative)
- Known bone marrow failure with pancytopenia — requires concurrent hematology consultation
- Minors under 18 years without parental/guardian consent (per UAE CDS Law 2026)
ER Red Flags — Seek Immediate Medical Attention If:
- Sudden severe pallor, syncope, or hemodynamic instability
- Acute abdominal pain with distension (suggestive of splenic sequestration)
- High-grade fever (>38.5°C) with rigors in a known CDA patient
- Dark urine with acute fatigue — possible hemolytic crisis
UAE Regulatory & Legal Compliance
- Federal Decree-Law No. 41 of 2024 (Art. 87): This genetic test is performed strictly within the scope of DHA-licensed diagnostic services, adhering to all provisions on medical liability and patient consent.
- CDS Law 2026 (Minors): Genetic testing of minors requires documented informed consent from both parents or legal guardians, with mandatory pre-test genetic counselling.
- UAE PDPL (Personal Data Protection Law): All genomic data is encrypted, stored on UAE-based secure servers, and never shared with third parties without explicit patient authorization.
- ISO 9001:2015 Certification: Cert: INT/EGQ/2509DA/3139 — ensuring standardized quality management across all pre-analytical, analytical, and post-analytical phases.
Patient FAQ & Clinical Guidance
Q1: What is the SEC23B Gene CDAN2 NGS Test, and who should undergo it?
The SEC23B gene NGS test is a comprehensive full-gene sequencing analysis that identifies pathogenic mutations causing Congenital Dyserythropoietic Anemia Type II, a rare hereditary blood disorder marked by ineffective red blood cell production, chronic anemia, jaundice, and progressive iron overload. This test is recommended for individuals of any age presenting with unexplained chronic hemolytic anemia, abnormal erythroblast morphology on bone marrow examination, elevated ferritin without clear etiology, or a positive family history of CDA. It is also critical for carrier screening in siblings of confirmed patients and for couples with consanguineous marriages who are planning pregnancy, as CDA II follows an autosomal recessive inheritance pattern. Genetic counselling is mandatory before and after testing.
س1: ما هو تحليل جين SEC23B لأنيميا تكون الكريات الحمر الخلقية من النوع الثاني، ومن يجب عليه إجراء هذا الفحص؟
تحليل جين SEC23B هو فحص جيني شامل يحدد الطفرات المسببة لأنيميا تكون الكريات الحمر الخلقية من النوع الثاني، وهو اضطراب دموي وراثي نادر. يوصى بهذا الفحص للأفراد الذين يعانون من فقر دم انحلالي مزمن غير مفسر، أو تشوهات في خلايا الدم الحمراء، أو تاريخ عائلي إيجابي للمرض، وكذلك للأزواج الذين يخططون للحمل في إطار الفحص الجيني قبل الزواج.
Q2: How is the SEC23B genetic test performed and what is the expected turnaround time?
The test is performed on a blood sample, extracted DNA, or a single drop of blood collected on a DNA FTA card via our DHA-licensed home phlebotomy service, with results delivered in 3 to 4 weeks. Our ISO-certified phlebotomist arrives at your home between 8 AM and 11 PM for a quick, virtually painless blood draw (3-5 mL of whole blood). The sample is transported in a validated cold-chain system directly to our molecular genetics laboratory, where DNA is extracted and the entire SEC23B gene is sequenced using Next Generation Sequencing (NGS) at a minimum of 1000x depth of coverage. Bioinformatics analysis identifies single nucleotide variants (SNVs), small insertions/deletions, and copy number variations. Every pathogenic or likely pathogenic variant is confirmed by orthogonal methods. You receive a comprehensive clinical report reviewed by a DHA-licensed hematologist and a clinical geneticist.
س2: كيف يتم إجراء تحليل جين SEC23B وما هي المدة المتوقعة لظهور النتائج؟
يتم إجراء الفحص على عينة دم كامل أو حمض نووي مستخلص أو قطرة دم واحدة على بطاقة FTA، حيث يقوم أخصائي سحب دم مرخص من هيئة الصحة بدبي بزيارة منزلية لجمع العينة. تُنقل العينة عبر سلسلة تبريد معتمدة إلى مختبر الجينات، وتظهر النتائج الشاملة خلال 3 إلى 4 أسابيع.
Q3: What do my SEC23B test results mean for me and my family members?
A positive result confirms a molecular diagnosis of CDAN2, identifying the specific SEC23B mutation responsible for your condition, enabling targeted family cascade screening and informed reproductive planning through genetic counselling. If two pathogenic variants are identified (one inherited from each parent), the diagnosis of CDA Type II is molecularly confirmed. This result allows your hematologist to tailor management — including iron chelation therapy, folic acid supplementation, and transfusion protocols — to your specific genetic profile. For family members, cascade testing can determine carrier status. A negative result (no pathogenic variant found) significantly reduces but does not entirely eliminate the possibility of CDA II, as rare deep intronic or regulatory mutations may escape detection. Variants of uncertain significance (VUS) require periodic reanalysis as scientific knowledge evolves. All results are discussed in a dedicated post-test telephonic consultation.
س3: ماذا تعني نتائج تحليل جين SEC23B لي ولأفراد أسرتي؟
النتيجة الإيجابية تؤكد تشخيص أنيميا تكون الكريات الحمر الخلقية من النوع الثاني جزيئياً، وتسمح بإجراء فحص متسلسل لأفراد الأسرة المعرضين للخطر. النتيجة السلبية تقلل الاحتمال بشكل كبير ولكنها لا تستبعده تماماً. جميع النتائج تتم مناقشتها في استشارة هاتفية بعد الفحص مع أخصائي أمراض الدم المرخص من هيئة الصحة بدبي.
Pre-Test Preparation & Requirements
- A detailed clinical history of the patient undergoing the SEC23B Gene CDAN2 Genetic Test must be provided, including prior blood transfusion records, ferritin levels, and bone marrow biopsy reports if available.
- A mandatory pre-test genetic counselling session is required to draw a comprehensive pedigree chart documenting all family members affected with Anemia Dyserythropoietic Type 2 (CDA II) or unexplained chronic anemia across at least three generations.
- No fasting is required for blood sample collection. If using an FTA card, the blood spot must air-dry completely before sealing in the provided biohazard envelope.
- If the patient has received a blood transfusion within the past 14 days, please inform the laboratory — a buccal swab or FTA card alternative may be recommended to avoid donor DNA interference.
Schedule Your SEC23B Genetic Today
DHA-Licensed Home Collection | 3 to 4 Weeks TAT | 2800 AED | Direct Insurance Billing
WhatsApp: +971 54 548 8731Available 8 AM – 11 PM | All UAE Emirates | ISO 9001:2015 Certified
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