Test Price
2,800 AED✅ Home Collection Available
SARS2 Gene Genetic Test for Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis (HUPRA Syndrome) in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SARS2 لفرط حمض اليوريك وارتفاع ضغط الدم الرئوي والفشل الكلوي والقلاء في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary | ملخص تنفيذي
99.9% Diagnostic Sensitivity – ISO‑accredited NGS processing for the SARS2 gene, ensuring reliable identification of HUPRA syndrome variants.
- ✓Premium Logistics: Hospital‑grade home sample collection via ISO‑certified cold chain (8 AM‑11 PM). VIP mobile phlebotomy included.
- ✓Clinical Guidance: Post‑test telephonic consultation with our senior clinical team to interpret results.
- ✓Direct Billing Verification: WhatsApp +971 54 548 8731
تحليل جيني دقيق بنسبة 99.9% لتشخيص متلازمة HUPRA المرتبطة بالجين SARS2،مع خدمة سحب منزلي معتمدة واستشارة طبية بعد الفحص.
Overview
The SARS2 gene encodes the mitochondrial seryl‑tRNA synthetase; pathogenic mutations cause the rare HUPRA syndrome (hyperuricemia, pulmonary hypertension, renal failure, alkalosis). This Genetic Test comprehensively sequences the entire coding region and splice sites, offering unparalleled diagnostic accuracy for affected individuals and carrier screening in families. يكشف هذا التحليل عن الطفرات الجينية المسببة لمتلازمة HUPRA ويوفر معلومات حاسمة للتشخيص والاستشارة الوراثية.
| Feature | Our Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Method | NGS (Next‑Generation Sequencing) – full gene analysis | Targeted Sanger of individual exons |
| Diagnostic Sensitivity | >99.9% | ~95% per exon; may miss deep intronic variants |
| Turnaround Time | 3–4 weeks | 6–8 weeks (if batched) |
| Sample Type | Blood, Extracted DNA, or One‑drop FTA Card | Whole blood only |
| Clinical Depth | Full variant interpretation with ACMG classification | Limited to known hotspots |
Physician Insight & Safety Protocols
"As a consultant physician with years of experience, I understand that a genetic diagnosis can feel overwhelming. This SARS2 NGS analysis is an extremely precise tool, but it must always be correlated with your child’s clinical picture and family history; it is not a standalone verdict. Please continue all prescribed treatments unless your specialist advises otherwise."
– Dr. PRABHAKAR REDDY, DHA License: 61713011
⚠ Medication Warning & Safety
Do not discontinue prescribed medication without consulting your doctor.
- Exclusion Criteria: None, provided a biological sample can be collected; a prior genetic counselling session is mandatory to draw a pedigree chart.
- ER Red Flags: Seek immediate medical attention if the patient experiences sudden worsening of breathing difficulty, chest pain, severe lethargy, or vomiting – these may indicate acute decompensation of pulmonary hypertension or metabolic crisis.
- Minors: According to UAE CDS Law 2026, genetic testing of minors requires explicit parental consent and a genetic counselling report.
UAE Regulatory & Compliance Standards
This test fully adheres to Federal Decree‑Law No. 41 of 2024 (Art. 87) on healthcare data, CDS Law 2026 concerning minors’ genetic information, and UAE PDPL for privacy. All processing is performed under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) certified quality management.
DHA Facility License: 9834453
Patient FAQ & Clinical Guidance
ما هو تحليل جين SARS2 وما هي أهميته؟
“The SARS2 gene NGS test identifies genetic variants causing hyperuricemia, pulmonary hypertension, renal failure, and alkalosis.” This test specifically looks for mutations in the SARS2 gene linked to HUPRA syndrome, enabling early intervention, family cascade testing, and accurate reproductive risk assessment. يساعد هذا الفحص في تأكيد تشخيص متلازمة HUPRA ويوجه خطة العلاج والاستشارات الوراثية للعائلة.
هل أحتاج إلى إحالة طبية لإجراء الفحص؟
“Direct patient testing is acceptable if accompanied by a clinical history and formal genetic counselling.” We strongly recommend referral from a nephrologist, pulmonologist, or clinical geneticist; however, we also accept self‑referred adults who complete the pre‑test counselling session. يمكن إجراء الفحص بتوصية من أخصائي أو بعد جلسة استشارة وراثية موثقة.
كم من الوقت يستغرق ظهور النتائج وماذا تعني؟
“Turnaround time is 3–4 weeks; results are interpreted using ACMG guidelines by board‑certified molecular pathologists.” You will receive a secure report categorising variants as pathogenic, likely pathogenic, or variant of uncertain significance, along with clinical correlation notes. Our telehealth team will walk you through the findings within 48 hours of report availability. تظهر النتائج خلال ٣-٤ أسابيع مع شرح مفصل من فريق طبي متخصص.
Pre‑test Requirements
- Provide a detailed clinical history of hyperuricemia, pulmonary hypertension, renal failure, or alkalosis.
- Attend a genetic counselling session to create a three‑generation pedigree chart (required for validation).
- Sample can be collected as whole blood (3 mL EDTA), extracted DNA, or one drop of blood on an FTA card. No special dietary or medication restrictions; continue all prescribed treatments.
2026 ICD‑10‑CM Codes
- Z15.89 – Genetic susceptibility to other disease
- E79.0 – Hyperuricemia without signs of inflammatory arthritis and tophaceous disease
- I27.0 – Primary pulmonary hypertension
LOINC Code
101264‑6 – SARS2 gene full sequence analysis
https://loinc.org/101264-6/
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