Also known as: RPL21 Gene Sequencing for Hypotrichosis Type 12 (NGS)
Test Price
2,800 AEDโ Home Collection Available
๐ Results in 3 โ 4 Weeks
RPL21 Gene Hypotrichosis Type 12 Genetic Test in UAE | 2800 AED | DHA Licensed Laboratory DNA Labs UAE
Executive Summary & Core Metrics
Core Metrics & Service Highlights
- Diagnostic Accuracy: 99.9% sensitivity via ISO 9001:2015 certified NGS sequencing with โฅ500x coverage.
- Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary post-test telephonic interpretation by a DHA-licensed Consultant Medical Geneticist.
- Insurance & Billing: Direct billing verification and pre-authorisation via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced NGS test deciphers the RPL21 gene for pathogenic variants linked to hypotrichosis type 12, a rare hereditary hair disorder presenting with sparse, fragile hair from birth. The assay delivers single-nucleotide resolution across all coding exons, enabling definitive diagnosis and informed family-planning decisions.
| Feature | This Test (RPL21 NGS) | Closest Alternative (Broad Panel) |
|---|---|---|
| Target Precision | Single-gene deep sequencing (RPL21) | Multi-gene panel covering 100+ hair-loss genes |
| Analytical Method | NGS with 500x average coverage | NGS or exome sequencing, variable coverage |
| Turnaround Time | 3 โ 4 Weeks | 6 โ 8 Weeks |
| Interpretation Burden | Low โ focused on one gene | High โ incidental findings may arise |
| Price | 2,800 AED | 4,500 โ 6,500 AED |
Physician Insight & Safety Protocols
"As a Consultant in Medical Genetics, I see firsthand the psychological burden that congenital hair loss places on patients and families. The RPL21 NGS test offers a precise molecular diagnosis that directly informs recurrence risks and guides genetic counselling. However, genomic results must always be interpreted in the context of a full clinical evaluation and detailed three-generation pedigree."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory โ Medication & Treatment Safety
โ Medication Warning
Do not discontinue any prescribed medication, including topical or systemic therapies for hair or immune conditions, without explicit instruction from your supervising physician. This test does not alter existing treatment plans.
Exclusion Criteria & Clinical Red Flags
Contraindications for Sample Collection
- Exclusion: Acute febrile illness within 48 hours of sample collection. Active skin infection at venipuncture site. Blood transfusion in the last 90 days (may obscure germline DNA).
- ER Red Flags: Sudden, rapidly progressive hair loss accompanied by fever, joint pain, or mucosal ulcers. Signs of secondary bacterial or fungal infection of the scalp (pain, pus, foul odour). Any severe allergic reaction during specimen collection.
Patient FAQ & Clinical Guidance
1. How does the RPL21 NGS test differ from a routine hair-loss blood panel?
The RPL21 Genetic Test pinpoints the root cause of inherited hair loss, enabling lifelong family counselling and precise prognosis. Routine blood panels only check for nutritional deficiencies or hormonal imbalances, not genetic mutations.
2. Can this test be performed on a newborn or infant?
Yes, the test requires only a small blood spot on an FTA card or minimal whole blood, safe for neonates when collected by a paediatric phlebotomist. We strictly follow UAE legal frameworks for minors, requiring parental consent and a genetic counselling session before sample collection.
3. How long do results take and what support is provided?
Results are typically available within 3 to 4 weeks. A complimentary telephonic interpretation session with a DHA-licensed Consultant Medical Geneticist is provided to explain findings, discuss inheritance patterns, and guide family screening options.
UAE Regulatory & Data Privacy Adherence
- DHA Facility License: No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
- Corporate Lab: DNA Labs UAE
- Data Protection: Full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of ICT in Health Fields.
- Medical Liability: All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety and informed consent.
- Quality Management: ISO 9001:2015 certified processing (Cert: INT/EGQ/2509DA/3139) ensuring consistent quality and accuracy.
- Home Collection Governance: VIP Mobile Phlebotomy operates under full clinical governance with temperature-controlled cold-chain transport. For queries or appointment scheduling, contact WhatsApp +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | RPL21 Gene Sequencing for Hypotrichosis Type 12 (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 โ 4 Weeks |
| Sample Type / Matrix | Whole blood (EDTA, 3-5 mL) or FTA card; home collection via VIP Mobile Phlebotomy |
| Methodology Used | Next-Generation Sequencing (NGS), โฅ500x coverage, coding exons ยฑ20 bp flanking regions |
| ICD-10-CM Code | Q84.0 (Congenital alopecia) |
| LOINC Code | 81247-9 (Gene targeted mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
["No specific fasting required", "No medication or diet restrictions"]
Medically Reviewed by Dr. Lina Osama Zaki Quteineh
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians