Test Price
2,800 AED✅ Home Collection Available
MYOC (Myocilin) Glaucoma, Open Angle Type 1A Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity via ISO 9001:2015 accredited NGS workflow (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test result interpretation by a Consultant Medical Genetics specialist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MYOC gene test employs Next-Generation Sequencing (NGS) to detect pathogenic and likely pathogenic variants associated with primary open-angle glaucoma type 1A (juvenile and adult-onset forms). Full-gene coverage including intronic boundaries and copy-number analysis ensures comprehensive variant detection, enabling early ophthalmologic surveillance and family cascade testing.
| Feature | DNA Labs UAE MYOC Test | Alternative Approach |
|---|---|---|
| Variant Detection | Full-gene NGS with copy-number analysis; 99.9% analytical sensitivity for SNVs, indels, and CNVs | Targeted genotyping or Sanger sequencing of select exons only; limited detection of structural variants |
| Methodology | Next-Generation Sequencing (NGS) – ISO 9001:2015 certified laboratory | Microarray-based genotyping or single-exon Sanger sequencing |
| Turnaround Time | 3–4 weeks from sample receipt | 6–8 weeks |
Physician Insight & Safety Protocols
As a Consultant Medical Genetics, I interpret MYOC sequencing results within the context of a three-generation family pedigree and intraocular pressure measurements. A pathogenic MYOC variant confers approximately 50% lifetime penetrance, meaning lifelong ophthalmologic surveillance is essential for carriers. A negative result reduces but does not eliminate the possibility of other hereditary glaucoma subtypes, and clinical follow-up should continue per standard guidelines.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed glaucoma medications or alter your treatment regimen without consulting your ophthalmologist. Genetic testing results are intended to complement, not replace, clinical judgment and ongoing medical care.
Exclusion Criteria & Emergency Red Flags
- Inability to provide informed consent. Mandatory pre-test genetic counselling session required under Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Acute eye trauma or recent intraocular surgery within the past 4 weeks.
- Severe coagulopathy contraindicating phlebotomy or buccal swab collection.
- If you experience sudden vision loss, intense eye pain, or halos around lights, seek emergency ophthalmic care immediately. Do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the MYOC gene glaucoma test and who should consider it?
This advanced DNA test identifies pathogenic variants in the MYOC gene responsible for juvenile and adult-onset primary open-angle glaucoma (type 1A), enabling proactive surveillance and family cascade testing. It is recommended for individuals with a family history of early-onset glaucoma, those diagnosed with open-angle glaucoma before age 40, or when an ophthalmologist suspects a hereditary pattern based on clinical presentation.
2. How is the test performed and how long does it take to get results?
A peripheral whole blood sample or buccal swab is collected via our VIP Mobile Phlebotomy service and sequenced using NGS. Results are delivered within 3–4 weeks from sample receipt. A pre-test genetic counselling session is included to construct a comprehensive family pedigree before sample processing commences.
3. What do the results mean and what are the next steps if a mutation is found?
A positive result indicates a hereditary predisposition to open-angle glaucoma, prompting intensified surveillance including earlier tonometry and optic nerve imaging as determined by your ophthalmologist. A negative result reduces but does not eliminate lifetime risk, as other genetic and environmental factors contribute to glaucoma development. Affected family members can be counselled and offered targeted testing in compliance with UAE genetic privacy laws under Federal Decree-Law No. 45 of 2021 on Personal Data Protection.
UAE Regulatory & Data Privacy Adherence
All genetic data processing at DNA Labs UAE complies with the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient genomic information is encrypted, access-controlled, and never shared without explicit written consent. Our DHA-licensed facility (License No. 1143) adheres to the highest standards of clinical data governance.
Clinical & Logistical Metadata
| Test Name | MYOC (Myocilin) Glaucoma, Open Angle Type 1A Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or buccal swab – VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with full-gene coverage and copy-number analysis |
| ICD-10-CM Code | H40.11X0, H40.1110, H40.1120, H40.1130 |
| LOINC Code | 21627-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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