MTR Gene Methylcobalamin Deficiency (CblG Type) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity โ ISO 9001:2015 accredited processing (Cert. INT/EGQ/2509DA/3139).
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection โ Available daily from 8 AM to 11 PM.
- Post-Test Clinical Guidance โ Telephonic result interpretation by qualified genetics professionals.
- Direct Billing & Insurance โ WhatsApp verification +971 54 548 8731.
Test Overview & Methodology
The MTR gene NGS test sequences the entire coding region of the MTR gene, detecting pathogenic variants responsible for methylcobalamin deficiency CblG typeโa treatable inborn error of vitamin B12 metabolism that can cause neonatal encephalopathy, developmental delay, and later-onset neurological decline. This comprehensive analysis uses next-generation sequencing (NGS) to provide a definitive molecular diagnosis, enabling early treatment and precise genetic counseling.
| Feature | Our Test โ MTR NGS | Biochemical Homocysteine/MMA |
|---|---|---|
| Methodology | Illumina NGS (full gene sequencing, 100ร coverage) | LC-MS/MS for homocysteine & methylmalonic acid |
| Analytical Sensitivity | 99.9% (single nucleotide variants, indels) | High for functional defect, no genotyping |
| Turnaround Time | 3โ4 Weeks | 1โ2 Days |
| Diagnostic Value | Definitive molecular diagnosis, carrier screening | Preliminary screening, monitoring treatment |
Physician Insight & Safety Protocols
โAs a consultant medical geneticist, I understand the profound uncertainty families face when a metabolic disorder is suspected. This NGS test delivers molecular clarity, but it is essential that results are interpreted within the full clinical context and family history. Used appropriately, it empowers tailored treatment and precise genetic counseling, transforming lives.โ
Safety Protocol & Exclusion Criteria
- Unstable acute condition: Do not proceed if the patient has a febrile illness, acute haemolytic anaemia, or received blood transfusion within the last 14 days (risk of sample contamination).
- Neonatal emergency: Infants with suspected metabolic crisis (lethargy, poor feeding, hypotonia) must be stabilised in an emergency setting before sample collection.
- Immediate red flags: If the patient develops seizures, loss of consciousness, respiratory distress, or acute psychosis, skip the test and seek ER care.
Advisory: Do Not Discontinue Prescribed Medication
Do not discontinue prescribed vitamin B12 or any other medication without consulting your doctor. This test requires a fresh blood sample; medication adjustments may be needed and must be directed by the treating physician.
Patient FAQ & Clinical Guidance
1. What is the MTR gene methylcobalamin deficiency CblG type genetic test?
This next-generation sequencing test analyzes the MTR gene to identify mutations causing methylcobalamin deficiency type CblG. It provides a definitive molecular diagnosis for a treatable inborn error of vitamin B12 metabolism that can lead to neurological and developmental problems if untreated.
2. How is the sample collected, and what preparation is required?
A simple blood draw (EDTA tube) is required. No fasting or medication changes are needed for DNA analysis. Our VIP mobile phlebotomy service collects the sample at your home between 8 AM and 11 PM, using temperature-controlled cold-chain logistics for sample integrity.
3. How long do results take, and do I need a referral?
Results are available within 3 to 4 weeks. A doctorโs referral is mandatory for pre-test genetic counseling and insurance billing. Our team will assist with coordinating the referral and scheduling a post-test telephonic consultation with the clinical geneticist.
UAE Regulatory & Data Privacy Adherence
This test is performed under the regulatory framework of the Dubai Health Authority (DHA) and in compliance with UAE federal laws governing health data and personal privacy. Patient data is handled in accordance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ ensuring the confidentiality and lawful processing of personal data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ governing electronic health records and digital data exchange.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ establishing patient consent requirements and clinical safety standards.
All laboratory facilities are ISO 9001:2015 certified (Cert. INT/EGQ/2509DA/3139) and operate under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | MTR Gene Methylcobalamin Deficiency (CblG Type) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AMโ11 PM. |
| Methodology Used | Illumina Next-Generation Sequencing (NGS) โ full gene sequencing, 100ร coverage |
| ICD-10-CM Code | E72.11 (Homocystinuria) |
| LOINC Code | 65853-3 (MTR gene mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |