Test Price
2,800 AED✅ Home Collection Available
MSX1 Gene Tooth Agenesis, Selective Type 1 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Precision Genomics for Tooth Development
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance with a DHA-licensed genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This test screens the MSX1 gene for variants causing selective tooth agenesis, a condition where permanent teeth fail to develop. Next-Generation Sequencing (NGS) provides comprehensive analysis of the entire coding region, detecting single nucleotide variants, small insertions/deletions, and copy number variants with high sensitivity.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | Detection of SNVs, small indels, and CNVs across the entire MSX1 coding region | Targeted analysis of known hot-spot mutations only |
| Methodology | Next-Generation Sequencing (NGS) with ≤0.1% VAF sensitivity | Sanger Sequencing |
| Turnaround Time | 3 to 4 Weeks | 1 to 2 Weeks |
| Clinical Utility | Comprehensive molecular diagnosis for familial risk assessment and clinical trial matching | Confirmatory test for known familial variants |
Physician Insight & Safety Protocols
"The MSX1 gene is a master regulator of craniofacial development. Identifying a pathogenic variant in a child with missing teeth not only explains the dental phenotype but also guides surveillance for associated conditions, such as cleft palate. This molecular clarity empowers families and clinicians to plan proactive, multidisciplinary care from an early age."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication and Treatment Continuity
⚠️ Important Advisory
Do not discontinue any prescribed medication, including dental bone density regulators or hormonal therapies, without consulting your primary physician. Genetic test results must inform, not replace, a clinical treatment plan.
Exclusion Criteria & Emergency Red Flags
- Active chemotherapy or whole-body radiation within the last 6 weeks (may affect DNA integrity).
- Current use of certain DNA-intercalating medications (provide a full list to the home care phlebotomist).
- Emergency: If a child with known tooth agenesis develops sudden facial asymmetry, unexplained fever, or pain, seek immediate emergency medical attention, as this could signal syndromic involvement rather than isolated dental issues.
Patient FAQ & Clinical Guidance
1. What is selective tooth agenesis type 1 and how is it inherited?
Selective tooth agenesis type 1 is a condition caused by variants in the MSX1 gene, leading to the congenital absence of one or more permanent teeth. It follows an autosomal dominant inheritance pattern, meaning a child has a 50% risk of inheriting the variant from an affected parent. This test confirms the genetic cause and enables accurate recurrence risk counselling.
2. How can this test help plan my child's future dental care?
Identifying a specific MSX1 gene variant allows your dental and orthodontic team to predict which permanent teeth will be missing. This enables early interventions such as space maintenance, orthodontic alignment, and implant planning from adolescence. It also distinguishes isolated tooth agenesis from syndromic forms, preventing unnecessary medical testing.
3. Why is NGS recommended over Sanger sequencing for this test?
Next-Generation Sequencing analyzes the complete MSX1 coding region with high sensitivity, detecting low-level mosaicism and structural variants that Sanger sequencing often misses. This comprehensive approach ensures no clinically relevant variant is overlooked, providing the highest diagnostic confidence for treatment planning and familial risk stratification.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance: All genetic data is handled in strict accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | MSX1 Gene Tooth Agenesis, Selective Type 1 Genetic Test |
| Price (AED) | 2800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral) or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | K00.0 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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