Test Price
2,800 AED✅ Home Collection Available
MOCOS Gene (Xanthinuria Type 2) Genetic Test in UAE | 2,800 AED | DHA Licensed Precision Diagnostics
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 certified Next Generation Sequencing (NGS) processing – certified INT/EGQ/2509DA/3139.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test result interpretation by a DHA-licensed Consultant Medical Geneticist – personalised management roadmap included.
- Insurance & Privacy: Direct billing verification via WhatsApp +971 54 548 8731. Full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
Test Overview & Methodology
This genetic test screens the entire coding region of the MOCOS gene to identify pathogenic variants responsible for hereditary Xanthinuria Type 2, a rare purine metabolism disorder. The result enables precise clinical management, dietary intervention, and cascade family screening. All positive findings are confirmed by Sanger sequencing, and ambiguous variants are reflexed to LC-MS/MS for orthogonal validation.
| Feature | Our Test – MOCOS NGS | Closest Alternative – Standard Biochemical Xanthine Analysis |
|---|---|---|
| Precision | 99.9% analytical sensitivity; detects all mutation types (missense, nonsense, splice‑site, CNVs) | Approximately 85% clinical sensitivity; may miss mild or intermittent xanthinuria |
| Methodology | NGS (Illumina NovaSeq™) with Sanger confirmation (LC‑MS/MS reflex for ambiguous variants) | HPLC or colorimetric assay of urinary xanthine/hypoxanthine |
| Turnaround Time | 3 to 4 Weeks | 2 to 4 Weeks (often requires repeated sampling) |
| Clinical Utility | Definitive molecular diagnosis, genotype‑phenotype correlation, family screening, reproductive risk | Suggestive only; requires genetic confirmation for full picture |
| Sample Type | Whole Blood, Extracted DNA, or One Drop of Blood on FTA Card | 24‑hour urine collection (cumbersome) |
Physician Insight & Safety Protocols
"Genetic testing for Xanthinuria Type 2 provides a definitive molecular answer where biochemical assays often fall short. However, a genetic result is most valuable when interpreted alongside the full clinical picture, including family history, dietary habits, and renal function. I counsel every patient to view this test as one chapter of a larger story that we navigate together."
– Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory – Do Not Self-Adjust Prescriptions
Never discontinue, alter, or initiate any medication (including xanthine oxidase inhibitors such as allopurinol or febuxostat) without direct guidance from your treating physician. Genetic results must be correlated with your current therapeutic regimen to avoid metabolic decompensation or adverse drug events.
Safety Exclusion Criteria & Emergency Red Flags
- Severe acute febrile illness or haemodynamic instability – defer testing until clinically stable.
- Recent blood transfusion (less than 4 weeks) may cause sample chimerism; a buccal swab or FTA card is preferred in such cases.
- If you experience sudden flank pain, oliguria, or signs of acute renal failure, seek emergency care immediately – these are urgent clinical events independent of the testing process.
- This test is not a standalone diagnostic tool for acute metabolic crisis; clinical correlation and specialist interpretation are mandatory.
Patient FAQ & Clinical Guidance
1. What is the clinical purpose of the MOCOS gene test?
Snippet-Optimised Answer: This test definitively identifies pathogenic MOCOS variants causing Xanthinuria Type 2, guiding lifelong dietary and pharmacological management to prevent xanthine stone formation and renal complications. It is ideal for symptomatic patients, their at-risk relatives, and reproductive planning. Pre-test genetic counselling is included to map your family pedigree.
2. How accurate is this genetic test compared to older methods?
Snippet-Optimised Answer: With 99.9% analytical sensitivity and comprehensive mutation coverage, our NGS test outperforms biochemical xanthine assays by detecting heterozygous carriers, copy-number variants, and novel mutations that traditional urine analysis misses. All positive findings are confirmed by Sanger sequencing.
3. What are the pre-test requirements and sample collection steps?
Snippet-Optimised Answer: A clinical history document and a mandatory genetic counselling session (to draw a comprehensive pedigree chart of family members affected by Xanthinuria Type 2) are required before sample submission. A venous blood sample or a single drop of blood on an FTA card is collected at your home via our ISO-certified mobile phlebotomy service. Results are available in 3 to 4 weeks, followed by a telephonic consultation with a Consultant Medical Geneticist.
4. Who should consider this test and which specialists typically order it?
Snippet-Optimised Answer: General physicians and primary care doctors initiate testing after observing unexplained hypouricemia, xanthine crystalluria, or recurrent urolithiasis in children or adults. Medical geneticists and metabolic specialists use the results for deep variant interpretation, genotype-phenotype correlation, and cascade screening. All referrals require DHA-approved genetic counselling.
UAE Regulatory & Data Privacy Adherence
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All extracted DNA is processed within UAE borders; no genetic data is exported without explicit written consent. Our laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and holds a valid DHA facility license.
Clinical & Logistical Metadata
| Test Name | MOCOS Gene (Xanthinuria Type 2) Genetic Test – NGS Full Gene Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card (Dried Blood Spot) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next Generation Sequencing (NGS) on Illumina NovaSeq™ with Sanger confirmation; LC-MS/MS reflex for ambiguous variants |
| ICD-10-CM Code | E79.8 (Hereditary xanthinuria), Z15.09 (Genetic susceptibility to other disease), Z13.8 (Encounter for screening for other specified diseases) |
| LOINC Code | 101513-5 (MOCOS gene full sequence analysis) |
| DHA Facility License & Address | DNA Labs UAE | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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