Test Price
2,800 AED✅ Home Collection Available
MANBA Gene Beta-Mannosidosis Genetic Test in UAE | 2800 AED | NGS Sequencing
Executive Summary & Core Metrics
A definitive molecular diagnostic test for beta-mannosidosis, utilizing next-generation sequencing to analyze the MANBA gene. This analysis offers >99.9% sensitivity for detecting pathogenic variants, enabling precise clinical diagnosis, carrier identification, and informed reproductive planning. The test is performed at an ISO 9001:2015 certified laboratory under the supervision of a Consultant Medical Genetics.
Test Overview & Methodology
The MANBA gene NGS test screens the entire coding region of MANBA for pathogenic variants linked to beta-mannosidosis, a rare lysosomal storage disorder. This analysis enables definitive molecular diagnosis, carrier identification, and informed clinical or reproductive decisions.
| Feature | Our Test (NGS Advantage) | Closest Alternative |
|---|---|---|
| Methodology | Next‑Generation Sequencing (Illumina), full gene coverage | Targeted mutation panel (few known sites only) |
| Analytical Sensitivity | >99.9% for single nucleotide variants & small indels | ~90% (depends on panel size) |
| Turnaround Time | 3 – 4 Weeks | 2 – 4 Weeks |
| Sample Type | Whole Blood, Extracted DNA, or FTA Card | Typically blood only |
| Home Collection | Available daily from 8 AM to 11 PM | Often not available |
Physician Insight & Safety Protocols
“A molecular diagnosis of beta-mannosidosis brings profound clarity to patients and their families. While this test demonstrates exceptional analytical accuracy, every result must be correlated with the clinical phenotype by a specialist in metabolic genetics. It is a powerful diagnostic tool, not a standalone verdict, and should be interpreted in conjunction with genetic counselling.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Patient Advisory & Exclusion Criteria
Patient Advisory Notice
Do not discontinue any prescribed medication without consulting your managing physician. This genetic test is a diagnostic tool and does not replace ongoing clinical care or specialist follow-up.
Exclusion Criteria for Testing
- Recent blood transfusion (within 4 weeks) – may interfere with germline DNA analysis.
- Testing of asymptomatic minors without documented parental/legal guardian consent and formal genetic counselling (per UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection).
- Acute metabolic crisis or suspected life‑threatening event – seek emergency care before scheduling this test.
Emergency Red Flags (Seek Immediate Medical Help):
- Sudden neurological decline, seizures, or loss of consciousness.
- Severe regression in motor or cognitive milestones.
- Unexplained, rapidly progressive organ involvement.
Patient FAQ & Clinical Guidance
1. What is the MANBA gene test used for?
The MANBA NGS test detects mutations in the MANBA gene to confirm a diagnosis of beta‑mannosidosis, identify carriers, and guide reproductive planning. It analyses all coding exons using high‑depth sequencing for precise variant calling.
2. How is the sample collected and what is the turnaround time?
A simple blood sample or DNA on an FTA card is collected at home by our mobile phlebotomy team. The entire cold‑chain process meets ISO 9001 standards and preserves sample integrity. Results are available in 3 to 4 weeks.
3. Is this covered by insurance in UAE?
We offer direct billing verification via WhatsApp at +971 54 548 8731 to confirm your insurance coverage before sample collection. Many UAE plans cover medically indicated genetic testing with prior approval.
4. What does the result mean for my family?
A positive result can indicate carrier status or an affected individual. This information is significant for family planning and screening of at‑risk relatives. We recommend a consultation with a genetic counsellor to discuss the implications.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Regulatory Compliance
- All genetic data handled under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health information managed in compliance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical testing safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Laboratory licensed under DHA Facility Number: 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | MANBA Gene Beta-Mannosidosis Genetic Test (NGS) |
| Price (AED) | 2800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card |
| Methodology Used | Next‑Generation Sequencing (Illumina) – Full Gene Coverage |
| ICD-10-CM Code | E77.1, Z14.8, Z31.430 |
| LOINC Code | 77641-7 (MANBA gene mutation analysis) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
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