Test Price
2,800 AEDโ Home Collection Available
LDHB Gene (Lactate Dehydrogenase B Deficiency) Genetic Test in UAE | 2800 AED | DHA License No. 1143
Executive Summary & Core Metrics
99.9% diagnostic accuracy via ISO 15189-accredited NGS. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM to 11 PM). Post-test clinical guidance teleconsultation. Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test analyzes the LDHB gene for pathogenic variants causing lactate dehydrogenase B deficiency, a rare autosomal recessive metabolic disorder often presenting with exertional myoglobinuria. It is essential for confirmation of clinical suspicion, family screening, and personalized management. Our laboratory uses targeted NGS with 100x coverage of the entire coding region and splice sites of the LDHB gene, ensuring high sensitivity for single nucleotide variants and small indels.
| Feature | Our Test (LDHB NGS) | Whole Exome Sequencing |
|---|---|---|
| Targeted Precision | 100% coding region of LDHB gene | All genes; may miss deep intronic variants |
| Turnaround Time | 3-4 Weeks | 6-10 Weeks |
| Clinical Relevance | Specifically for LDHB deficiency | Incidental findings risk |
| Cost in UAE (AED) | 2800 | ~5000 |
Physician Insight & Safety Protocols
โThe LDHB NGS test is a cornerstone for diagnosing this rare enzymopathy. I emphasize that a positive result should always be correlated with clinical history and muscle enzyme levels; a negative result does not entirely rule out other myopathies. Patients must never discontinue prescribed medications without consulting their physician.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Safety
Do not discontinue or modify any prescribed medication without direct consultation with your treating physician. Test results should be discussed only after genetic counseling.
Exclusion Criteria & Safety Alerts
- Minors: Genetic testing requires parental or guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability and the UAE Personal Data Protection Law (PDPL).
- Pregnancy/Breastfeeding: Not contraindicated, but post-test genetic counseling is essential.
- Immunocompromised: Home collection uses sterile single-use kits with cold-chain logistics.
- Emergency Red Flags: If you experience sudden severe muscle pain, dark urine, or inability to move limbs, proceed to the nearest emergency department immediatelyโdo not wait for test results.
Patient FAQ & Clinical Guidance
1. What is lactate dehydrogenase B deficiency?
Lactate dehydrogenase B deficiency is a rare autosomal recessive metabolic disorder causing exertional myoglobinuria. It leads to inability to recycle lactate in muscles, resulting in muscle cell breakdown and dark urine after intense exercise. Our NGS test identifies disease-causing mutations in the LDHB gene, enabling early intervention.
2. How is the LDHB Genetic Test performed?
Our test uses Next-Generation Sequencing to analyze the entire LDHB gene from a blood sample. A hospital-grade phlebotomist collects a blood sample at your home between 8 AM and 11 PM under cold-chain conditions. DNA is extracted, amplified, and sequenced with 100x coverage, detecting single nucleotide variants and small deletions. Results are interpreted by clinical geneticists.
3. How should I interpret my LDHB gene test results?
A positive result confirms LDHB deficiency; a negative result reduces suspicion but does not exclude all metabolic myopathies. We provide a telephonic post-clinical guidance session with a specialist to explain implications, family risk, and management strategies. Always correlate with clinical symptoms and consult your physician.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic data is encrypted, stored securely, and never shared without explicit consent. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds DHA Facility License No. 1143 and operates under ISO 15189 accreditation.
Clinical & Logistical Metadata
| Test Name | LDHB Gene Sequencing (Lactate Dehydrogenase B Deficiency) |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole blood (peripheral) or FTA card; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next-Generation Sequencing (NGS) โ Targeted gene panel |
| ICD-10-CM Code | E74.09 (Other disorders of carbohydrate metabolism), R82.3 (Myoglobinuria) |
| LOINC Code | 88247-9 (LDHB gene targeted mutation analysis) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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