Test Price
2,800 AED✅ Home Collection Available
LAMC3 Gene Cortical Malformations, Occipital Genetic Test in UAE
Executive Summary & Core Metrics
- ✔99.9% Diagnostic Sensitivity – ISO 9001:2015 Certified & CAP‑aligned NGS workflow.
- ✔Premium Home Collection – Hospital‑grade cold‑chain logistics with VIP Mobile Phlebotomy (8 AM‑11 PM) for standard blood draws.
- ✔Post‑Test Clinical Guidance – Complimentary telephonic interpretation with a DHA‑licensed genetic counsellor.
- ✔Insurance Direct Billing – Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
The LAMC3 gene test employs next‑generation sequencing to detect pathogenic variants causing occipital cortical malformations, a severe neurodevelopmental disorder often presenting with intractable epilepsy and intellectual disability. Early molecular confirmation empowers targeted clinical management and family planning. The test sequences all coding exons and detects single nucleotide variants, small indels, and large deletions/duplications associated with autosomal recessive occipital polymicrogyria.
| Feature | Our Test (NGS) | Alternative (Sanger) |
|---|---|---|
| Resolution | Full gene + CNV | Single exon |
| Sensitivity | 99.9% SNV | ~95% |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Sample | Blood / FTA Card | Blood only |
Physician Insight & Safety Protocols
"The LAMC3 test provides a molecular diagnosis for families navigating the uncertainty of occipital cortical malformations. Each result must be carefully correlated with neuroimaging and clinical presentation. Our team ensures that every finding is interpreted in the context of the full clinical picture, guiding next steps with compassion and precision."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Precautions
⚠️ Critical Medication Notice
Do not discontinue any prescribed antiepileptic or other medication without explicit instruction from your treating physician. Altering therapy prematurely may provoke seizure exacerbation.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Active febrile illness, recent blood transfusion (<2 weeks), or chemotherapy‑induced pancytopenia.
- ER Red Flags (stop collection, seek emergency care): Sudden loss of consciousness, prolonged seizure (>5 min), severe headache with vomiting.
- Genetic counselling is mandatory prior to sample submission; a detailed family pedigree must be provided.
Patient FAQ & Clinical Guidance
1. What is the LAMC3 gene and how do mutations cause cortical malformations?
Mutations in the LAMC3 gene disrupt radial glial fiber architecture, impairing neuronal migration to the occipital cortex, which results in laminar disorganization and cortical dysplasia. This leads to structural brain anomalies typically visible on MRI and often manifests as infantile spasms or refractory focal seizures. The test sequences all coding exons, detecting single nucleotide variants, small indels, and large deletions/duplications that have been associated with autosomal recessive occipital polymicrogyria and related malformations.
2. How is the sample collected in the UAE and what is the turnaround time?
A certified phlebotomist visits your home between 8 AM and 11 PM to draw a small blood sample, or you may submit extracted DNA on an FTA card, ensuring cold‑chain integrity until laboratory processing. The sample is transported under ISO‑validated temperature control to our DHA‑licensed facility, with results reported in 3 to 4 weeks. You will receive an SMS notification when the report is ready for download via our secure portal.
3. Is the LAMC3 NGS test covered by insurance in Dubai and Abu Dhabi?
Most major UAE insurers, including Daman, AXA, and NAS, provide coverage for medically indicated genetic testing under genomic medicine riders, subject to pre‑authorization. Our billing team verifies your policy and obtains approval before the procedure; direct billing is available for most networks. For an immediate eligibility check, send your insurance card copy via WhatsApp to +971 54 548 8731.
UAE Regulatory & Data Privacy Adherence
Your Data Is Protected Under UAE Law
This facility strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑controlled, and processed solely for diagnostic and clinical purposes. Patient consent and safety protocols comply with Federal Decree-Law No. 4 of 2016 on Medical Liability.
DNA Labs UAE is ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) and regulated by the Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | LAMC3 Gene Sequencing (Cortical Malformations, Occipital) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) – Full gene + CNV analysis |
| ICD-10-CM Code | Q04.8 (Other specified congenital malformations of brain) |
| LOINC Code | 62374-4 (LAMC3 gene mutation analysis in Blood or Tissue by NGS) |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians