Test Price
2,800 AED✅ Home Collection Available
KRT16 Gene Pachyonychia Congenita Type 1 Genetic Test in UAE | DNA Labs UAE
Executive Summary & Core Metrics
Executive Summary: Next‑Generation Sequencing (NGS) analysis of the entire coding region of the KRT16 gene to confirm or exclude Pachyonychia Congenita Type 1 (PC‑1) with 99.9% diagnostic sensitivity.
- ✓ Accuracy Guarantee: ISO 15189‑compliant NGS on Illumina NovaSeq, validated by Sanger confirmation of all pathogenic variants.
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection. Available daily from 8 AM to 11 PM.
- ✓ Clinical Guidance: Complimentary telephonic post-test clinical interpretation session with a DHA-licensed genetic counsellor.
- ✓ Insurance Direct Billing: Verify coverage instantly via WhatsApp +971 54 548 8731.
- ✓ Core Pricing: 2,800 AED (All-inclusive).
Test Overview & Methodology
The KRT16 Gene Pachyonychia Congenita Type 1 Genetic Test detects pathogenic variants in the KRT16 (keratin 16) gene, the definitive molecular cause of PC‑1, a rare autosomal dominant disorder characterised by painful palmoplantar keratoderma, hypertrophic nail dystrophy, and oral leukokeratosis. This test supports accurate diagnosis, family screening, and reproductive planning.
| Feature | Our Test (NGS) | Traditional Sanger (Single‑Exon) |
|---|---|---|
| Methodology | Full‑gene NGS + Sanger validation | Sanger sequencing of selected exons only |
| Detection Rate | >99% of known point mutations & small indels | ~80% if only hotspot exons tested |
| Turnaround Time | 3–4 weeks | 4–8 weeks (incremental) |
| Reporting | ACMG‑classified variants with clinical correlation | Limited variant interpretation |
Physician Insight & Safety Protocols
“A positive KRT16 mutation confirms the diagnosis of Pachyonychia Congenita Type 1, however, clinical expressivity is highly variable even among affected members of the same pedigree. Management relies on interdisciplinary collaboration between dermatology, pain medicine, and clinical genetics for optimal outcomes. I recommend correlating this molecular finding with a thorough physical examination and family history review.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Safety Protocols
⚠️ Critical Safety Information
Do not discontinue any prescribed medication or alter your treatment plan without consulting your doctor. This genetic test provides diagnostic information, not therapeutic instructions. Informed consent is obtained prior to sample collection in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Exclusion Criteria & Emergency Red Flags
- ⛔ Exclusion Criteria (Do Not Proceed Without Medical Clearance): Active febrile illness, recent blood transfusion (<4 weeks), inability to provide informed consent, severe coagulopathy.
- 🚨 Emergency Red Flags – Seek Immediate Medical Attention: New onset of severe, rapidly spreading skin blisters with fever; signs of systemic infection (chills, tachycardia, confusion); sudden inability to walk due to plantar pain; swelling or pus from nail folds.
Patient FAQ & Clinical Guidance
1. Can this test diagnose Pachyonychia Congenita Type 1 even if I have no family history?
A: Yes, this NGS panel can identify a de novo KRT16 mutation, which accounts for approximately 40% of PC‑1 cases where neither parent is affected. Every pathogenic variant is confirmed by Sanger sequencing to ensure a false‑negative‑free result. After a positive finding, genetic counselling is provided to discuss inheritance risk and family testing options.
2. What type of sample is required and how should I prepare?
A: A simple blood draw (3‑5 mL whole blood in EDTA tube), extracted DNA, or a dried blood spot on an FTA card is all that is needed; no fasting or special preparation is required. A pre‑test genetic counselling session collects a three‑generation pedigree to enhance variant interpretation. VIP home collection by a licensed phlebotomist is arranged at your convenience and is available daily from 8 AM to 11 PM.
3. Will my insurance cover this genetic test and how do I claim?
A: Most UAE insurers provide coverage for medically indicated single‑gene tests when referred by a DHA‑licensed dermatologist or geneticist; our team handles direct billing after verifying your policy via WhatsApp at +971 54 548 8731. If not covered, a detailed invoice and a standardised medical necessity letter support your reimbursement claim.
UAE Regulatory & Data Privacy Adherence
UAE Regulatory Compliance & Data Privacy: This test is performed under DHA-licensed facility #1143 in strict adherence to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted and stored on sovereign UAE servers. Clinical safety and patient consent protocols comply with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | KRT16 Gene Pachyonychia Congenita Type 1 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Q84.5, Z15.09, Z13.79 |
| LOINC Code | 94477-7 |
| DHA Facility License & Address | DHA License 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians