Test Price
2,800 AED✅ Home Collection Available
KEAP1 Gene Goitre, Multinodular Genetic Test in UAE 2,800 AED | DHA-Approved NGS Sequencing
Executive Summary & Core Metrics
Accurate genetic risk stratification for familial nontoxic multinodular goiter through Next Generation Sequencing of the KEAP1 gene, enabling early intervention and personalised management pathways.
- Diagnostic Accuracy: 99.9% sensitivity for point mutations and small indels via ISO-accredited NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test result interpretation by a Consultant Medical Genetics specialist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
- Regulatory: Compliant with UAE Federal Decree-Law No. 4 of 2016 on Medical Liability for clinical safety and informed consent.
Test Overview & Methodology
The KEAP1 gene NGS test screens for pathogenic germline variants associated with familial nontoxic multinodular goiter (MNG) and related endocrine disorders. This test provides precise genetic risk stratification, enabling early intervention, targeted surveillance, and personalised clinical management for patients and their families.
Next Generation Sequencing (NGS) of the full coding region plus splice sites ensures comprehensive detection of single nucleotide variants and small insertions or deletions. Results must be correlated with clinical findings, family history, and post-test genetic counselling.
| Feature | Our Test – KEAP1 NGS | Single‑Gene Sanger |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) | Sanger Sequencing |
| Diagnostic Yield | 99.9% sensitivity for point mutations & small indels | ~99% sensitivity, limited to targeted regions |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Comprehensiveness | Full coding region + splice sites | Selected amplicons only |
Physician Insight & Safety Protocols
"As a DHA-licensed Consultant Medical Genetics specialist, I emphasise that genetic results must always be interpreted within the full clinical context, including family history and biochemical markers. A pathogenic KEAP1 mutation indicates elevated lifetime risk—not guaranteed disease expression. Comprehensive pre- and post-test genetic counselling is mandatory, and referral to an endocrinologist for holistic evaluation is strongly recommended."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory – Medication Continuity
Do not discontinue or adjust any prescribed thyroid medication, anticoagulant, or other therapy without direct consultation with your treating physician. Genetic test results complement—but do not replace—ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
- Patients who have not received pre-test genetic counselling (mandatory per UAE regulations for all genetic testing).
- Poor-quality DNA samples (degraded, haemolysed, or insufficient quantity).
- Individuals unable to provide informed consent.
Seek emergency care immediately if you experience: sudden neck swelling, difficulty breathing or swallowing, severe hoarseness, fever with palpitations—symptoms suggestive of thyroid storm or airway compromise.
Patient FAQ & Clinical Guidance
1. What does a pathogenic KEAP1 gene variant mean for my health?
A pathogenic KEAP1 gene variant significantly elevates the lifetime risk of developing familial nontoxic multinodular goiter and may predispose to thyroid dysfunction. This result does not confirm disease—it guides personalised surveillance and preventive care.
2. Why is genetic counselling mandatory before this test?
Pre-test genetic counselling ensures you fully understand the implications of testing, including the potential for incidental findings, family member risk, and the psychological impact of results. It is a regulatory requirement under UAE health data protection laws.
3. What sample types are accepted for KEAP1 genetic testing?
We accept whole blood (EDTA tube), extracted DNA, or a dried blood spot on an FTA card. Collection is minimally invasive with only mild temporary discomfort during venipuncture.
4. How long until I receive my results?
Standard turnaround time is 3 to 4 weeks from sample receipt at the laboratory. Results are delivered electronically and followed by a telephonic consultation with our genetics team to explain the report.
UAE Regulatory & Data Privacy Adherence
Data Protection & Clinical Compliance Framework
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All personal health data is processed with strict confidentiality, access controls, and lawful consent mechanisms.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Electronic health records and telehealth components comply fully with national cybersecurity and interoperability standards.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: All clinical testing, sample collection, and result interpretation adhere to the medical liability framework ensuring patient safety and informed consent.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) – Quality management system audited annually.
This service is operated under DHA Facility License Number 1143. All clinical interpretations are provided by DHA-licensed medical professionals.
Clinical & Logistical Metadata
| Test Name | KEAP1 Gene Sequencing – Familial Nontoxic Multinodular Goiter Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next Generation Sequencing (NGS) – Full Coding Region & Splice Sites |
| ICD-10-CM Code | E04.2, Z13.29 |
| LOINC Code | 101351-3 |
| DHA Facility License & Address | DHA License No: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab: DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians