Test Price
2,800 AEDโ Home Collection Available
IL2RA Gene (Interleukin-2 Receptor Alpha) Deficiency โ NGS Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity โ ISO 9001:2015 accredited NGS processing, ensuring unparalleled precision across all coding exons, splice junctions, and regulatory regions.
- Premium Logistics โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across all UAE emirates.
- Clinical Guidance โ Post-test telephonic interpretation with a DHA-licensed Consultant Medical Geneticist in English or Arabic.
- Insurance & Billing โ Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This NGS-based assay interrogates the IL2RA gene for pathogenic mutations linked to CD25 deficiencyโa severe combined immunodeficiency presenting with dermatological, immunological, and skeletal abnormalities. The test delivers comprehensive coverage of every coding exon, splice junction, and regulatory region, achieving 99.9% sensitivity while detecting copy-number variants missed by conventional Sanger sequencing.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Method | Next-Generation Sequencing (high coverage, CNV detection) | Single-gene Sanger analysis |
| Sensitivity | 99.9% (including deep intronic + CNV) | ~95% (misses large rearrangements) |
| Turnaround Time | 3โ4 weeks (21โ28 business days) | 4โ6 weeks (limited centres) |
Physician Insight & Safety Protocols
โA pathogenic variant in IL2RA provides critical diagnostic insight, yet a complete clinical picture requires correlation with immunological biomarkers and physical examination findings. I counsel every patient to view this genetic result as a foundation for a comprehensive, individualized management plan rather than a standalone diagnosis.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory Notice โ Medication Continuity
โ ๏ธ Do not discontinue or alter prescribed medication without consulting your doctor.
Genetic results may influence long-term therapeutic strategies, but immediate medication adjustments must only be made under direct clinical supervision. Abrupt changes can lead to adverse outcomes, particularly in immunosuppressed patients.
Safety Exclusion Criteria & Clinical Red Flags
Exclusion Criteria & Emergency Indicators
- Exclusion: Active systemic infection, recent blood transfusion (<4 weeks), or inability to provide informed consent.
- Emergency Red Flags: Worsening skin blistering, intractable diarrhea, unexplained high fever, or signs of adrenal crisisโseek immediate medical attention.
Patient FAQ & Clinical Guidance
1. What is the IL2RA genetic test and why is it recommended?
The IL2RA NGS test identifies mutations in the interleukin-2 receptor alpha gene, which is critical for proper immune function. Pathogenic variants in this gene are associated with severe combined immunodeficiency (SCID), autoimmune skin disorders, and bone abnormalities. Early genetic diagnosis enables timely intervention with hematopoietic stem cell transplantation or targeted immunotherapy.
2. How is the specimen collected and prepared for NGS analysis?
A small sample of whole blood (EDTA tube), extracted DNA, or a single drop of blood on an FTA card is collected by a certified phlebotomist via our VIP Mobile Phlebotomy service. The sample is transported under temperature-controlled cold-chain conditions to preserve nucleic acid integrity, available daily from 8 AM to 11 PM.
3. Why is NGS the definitive method for IL2RA analysis compared to older techniques?
Next-generation sequencing delivers comprehensive coverage of every coding exon, splice junction, and regulatory region, achieving 99.9% sensitivity while detecting copy-number variants and deep intronic mutations that are routinely missed by conventional Sanger sequencing. This higher resolution reduces the risk of false-negative results and provides a more complete genetic picture.
4. What is the turnaround time and how will I receive my results?
Results are delivered within 3โ4 weeks (21โ28 business days) from sample receipt. You will receive a comprehensive PDF report via secure email, followed by a telephonic consultation with a DHA-licensed Consultant Medical Geneticist to interpret the findings and discuss clinical implications.
UAE Regulatory & Data Privacy Adherence
This genetic testing service operates in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ ensuring secure handling, storage, and transmission of all genetic and personal data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ governing the digital infrastructure and telehealth components of this service.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ safeguarding patient safety and clinical consent protocols throughout the testing pathway.
- ISO 9001:2015 (Certificate: INT/EGQ/2509DA/3139) โ accredited quality management system governing all laboratory processes.
Clinical & Logistical Metadata
| Test Name | IL2RA Gene (Interleukin-2 Receptor Alpha) NGS Sequencing โ CD25 Deficiency Panel |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks (21โ28 business days) |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card Bloodspot โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM โ 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV detection, deep intronic coverage, and confirmatory Sanger validation |
| ICD-10-CM Code | D81.4 (Severe combined immunodeficiency due to IL-2 receptor alpha deficiency) |
| LOINC Code | 21666-1 (IL2RA gene mutation analysis) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | DNA Labs UAE โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
ุฏุนู ุซูุงุฆู ุงููุบุฉ ู ุชุงุญ
ุงูุชุญูู ู ู ุงูุชุบุทูุฉ ุงูุชุฃู ูููุฉ
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
ุชููู ุนู ุงูุชุฎู ูู. ุฃุฑุณู ุตูุฑุฉ ู ู ุจุทุงูุฉ ุงูุชุฃู ูู ููุตูุฉ ุงูุทุจูุจ ุฅูู ูุฑูู ุงูุชุญูู ุงูู ุนุชู ุฏ ู ู ููุฆุฉ ุงูุตุญุฉ ุจุฏุจู ุนุจุฑ ุงููุงุชุณุงุจ. ุงุญุตู ุนูู ุชุญุฏูุซ ุงูุญุงูุฉ ูู ุฏูุงุฆู.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians