Test Price
2,800 AED✅ Home Collection Available
HPGD Gene Hypertrophic Osteoarthropathy Type 1 Genetic Test in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين HPGD لتضخم العظام والجلد من النوع الأول في الإمارات | 2,800 درهم | معتمد من هيئة الصحة بدبي 2026
8 AM – 11 PM Daily
Executive Summary | ملخص تنفيذي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: Paid Hospital-Grade Home Collection via ISO-Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy across all seven emirates.
Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by qualified genetic counsellors.
Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731 — Pre-approval confirmed before sample collection.
ضمان الدقة: حساسية تشخيصية بنسبة 99.9% عبر معالجة بتقنية التسلسل الجيني من الجيل التالي (NGS) معتمدة من ISO 9001:2015. تشمل الخدمة استشارة وراثية هاتفية بعد صدور النتيجة، وسحب عينات منزلية باردة النقل وفق معايير دولية معتمدة.
Test Overview
The HPGD Gene Hypertrophic Osteoarthropathy Type 1 Genetic Test is a definitive molecular diagnostic assay that sequences the entire coding region of the HPGD gene (15-hydroxyprostaglandin dehydrogenase) using Genetic Test confirms or excludes Primary Hypertrophic Osteoarthropathy Type 1 (PHOAR1), also known as pachydermoperiostosis, an autosomal recessive disorder characterised by digital clubbing, periostosis, and pachydermia. يكتشف هذا الفحص الطفرات المسببة في جين HPGD المسؤول عن تقويض البروستاغلاندين E2، مما يسمح بتشخيص جيني دقيق وتفريق عن الأسباب الثانوية لتضخم العظام.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | NGS (Next Generation Sequencing) | Capillary Sanger Sequencing |
| Coverage | Full gene — all exons, splice sites, and flanking intronic regions | Single amplicon per reaction; limited throughput |
| Diagnostic Sensitivity | 99.9% | ~95% (variant-dependent) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Sample Options | Whole Blood / Extracted DNA / Dried Blood Spot (FTA Card) | Whole Blood only |
| Price | 2,800 AED | Variable (1,800–3,500 AED) |
Physician Insight & Clinical Correlation
"A positive HPGD variant report must always be interpreted within the full clinical context — digital clubbing, periostosis, and skin thickening together form the diagnostic triad of primary hypertrophic osteoarthropathy. I remind every patient that genetic confirmation provides clarity but does not replace clinical follow-up with your dermatologist and rheumatologist. A negative result likewise does not exclude secondary causes, and further investigation may still be warranted if symptoms persist."
— Dr. Prabhakar Reddy, DHA License No. 61713011
⚠ Important Clinical Notice
Do not discontinue any prescribed medication without consulting your doctor. This genetic test is diagnostic in nature and does not assess pharmacological response. Medications for joint pain, skin manifestations, or prostaglandin-modulating therapies must be managed exclusively by your treating physician.
🛡 Exclusion Criteria & Emergency Red Flags
Exclusion Criteria:
- Individuals under 18 years of age without documented guardian consent (per UAE CDS Law 2026, Art. 12).
- Inability or unwillingness to provide informed consent for genetic data processing under UAE PDPL.
- Prior allogeneic bone marrow transplant within 90 days (donor DNA interference).
- Active chemotherapy within 14 days (may affect leukocyte-derived DNA quality).
Seek Immediate Medical Attention If:
- Acute, severe bone or joint pain with erythema and warmth — may indicate secondary osteomyelitis.
- Sudden worsening of digital clubbing with cyanosis — evaluate for underlying pulmonary or cardiac pathology.
- Skin ulceration or breakdown over affected joints with signs of systemic infection (fever >38.5°C).
- New-onset respiratory distress in a patient with known hypertrophic osteoarthropathy.
Clinical Indications & Referring Specialists
Dermatologist
Primary referral for pachydermia, seborrhea, and cutis verticis gyrata — hallmark skin manifestations of PHOAR1.
Medical Geneticist
Essential for pre-test counselling, pedigree analysis, variant interpretation, and cascade family screening.
Rheumatologist
Manages periostosis, arthralgia, and joint effusions; differentiates from secondary hypertrophic osteoarthropathy.
Sample Collection & Pre-Test Requirements
Accepted Sample Types:
- Whole Blood (EDTA tube, 3–5 mL)
- Extracted DNA (≥1 µg, A260/A280 ratio 1.8–2.0)
- Dried Blood Spot on FTA Card (one drop, adequately air-dried)
Cold-Chain Transport:
All liquid samples transported at 2–8°C via ISO-certified冷链 logistics within 4 hours of collection. FTA cards shipped at ambient temperature in moisture-barrier pouches.
Mandatory Pre-Test Steps:
- Genetic Counselling Session: A certified genetic counsellor must draw a detailed three-generation pedigree chart documenting all family members affected with or suspected of hypertrophic osteoarthropathy.
- Clinical History Documentation: Complete history including age of onset, progression of digital clubbing, skin changes, and joint symptoms.
- Informed Consent: Signed consent form compliant with UAE PDPL for genetic data handling, storage, and reporting.
- Fasting: Not required for DNA-based testing.
UAE Regulatory Compliance & Data Protection
Federal Decree-Law No. 41 of 2024 (Art. 87): This genetic testing service operates under full licensure from the Dubai Health Authority (Facility License No. 9834453). All genetic data is processed, stored, and reported in strict accordance with Article 87 provisions governing genomic testing and hereditary disease diagnostics in the UAE.
CDS Law 2026 — Minors: Genetic testing of individuals below 18 years of age requires mandatory, documented consent from a legal guardian and a court-approved medical necessity determination. Testing minors for adult-onset conditions without immediate clinical benefit is prohibited.
UAE PDPL Compliance: All patient genetic data is encrypted at rest (AES-256) and in transit (TLS 1.3). Data retention follows UAE Personal Data Protection Law guidelines. Patients retain the right to request data deletion, restrict processing, and receive a complete copy of their genetic data in standard BAM/VCF format.
ISO 9001:2015 Certification: Quality Management System certified under Certificate No. INT/EGQ/2509DA/3139, ensuring standardised operating procedures across all phases — pre-analytical, analytical, and post-analytical.
Frequently Asked Questions
1. What does a positive HPGD gene test mean for my diagnosis and treatment?
A positive HPGD gene test confirms a diagnosis of Primary Hypertrophic Osteoarthropathy Type 1 with greater than 99.9% diagnostic certainty, enabling your specialist team to initiate targeted prostaglandin-modulating therapies and establish a personalised surveillance plan for skeletal and cutaneous manifestations. Treatment typically includes COX-2 inhibitors, corticosteroids for acute flares, and regular rheumatologic and dermatologic follow-up — but all therapeutic decisions must be made by your treating physicians based on your complete clinical picture.
2. How is the sample collected and how long do results take?
Sample collection is performed via a standard venipuncture (blood draw) or a simple finger-prick for FTA card collection by a DHA-licensed phlebotomist during your scheduled home visit between 8 AM and 11 PM, with results delivered within 3 to 4 weeks from the date the sample reaches our ISO-certified genomic laboratory. The comprehensive report includes variant nomenclature (HGVS format), zygosity, pathogenicity classification per ACMG guidelines, and clinical correlation recommendations.
3. Is this test covered by insurance, and what support is available after results?
Direct billing verification with all major UAE insurers is processed via WhatsApp at +971 54 548 8731 before your appointment, and every patient receives a complimentary telephonic post-test genetic counselling session to review results, discuss implications for family members, and plan any necessary cascade testing. يتم التحقق من تغطية التأمين الصحي عبر الواتساب قبل موعد سحب العينة، ويحصل كل مريض على جلسة استشارة وراثية هاتفية مجانية بعد صدور النتيجة لمناقشة النتائج وآثارها على أفراد الأسرة والتخطيط للفحوصات الجينية المتتابعة.
Schedule Your HPGD Genetic Today
Home Collection Available Across All Emirates — Dubai, Abu Dhabi, Sharjah, Ajman, Umm Al Quwain, Ras Al Khaimah, and Fujairah
Facility License: 9834453 | DHA-Registered | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139)
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
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All reports reviewed by DHA-Certified physicians