Test Price
2,800 AED✅ Home Collection Available
FREM2 Gene (Fraser Syndrome) Genetic Test in UAE | 2,800 AED | DHA-Licensed Lab
Executive Summary & Core Metrics
This advanced genetic test provides 99.9% diagnostic sensitivity for Fraser syndrome through ISO 9001:2015‑accredited next‑generation sequencing. The service includes VIP mobile phlebotomy with temperature‑controlled cold‑chain home collection (available daily from 8 AM to 11 PM), post‑test telephonic clinical guidance, and direct insurance billing verification via WhatsApp at +971 54 548 8731.
- Turnaround Time: 3–4 weeks
- Sample Type: Whole blood (3–5 mL in EDTA tube), extracted DNA, or dried blood spot
- Methodology: Next‑Generation Sequencing (NGS) – full coding region plus flanking intronic regions
- Price: 2,800 AED (includes home collection, clinical report, and genetic counselling)
Test Overview & Methodology
The FREM2 gene encodes the extracellular matrix protein FRAS1 and is responsible for Fraser syndrome, a rare autosomal recessive disorder characterized by cryptophthalmos, syndactyly, and renal agenesis. This next‑generation sequencing test analyzes the full coding sequence of the FREM2 gene to identify pathogenic single nucleotide variants, small insertions/deletions, and copy number changes, enabling definitive confirmation of a clinical diagnosis and guiding multidisciplinary management and family planning.
| Feature | Our FREM2 NGS Test | Alternative Single‑Gene Testing |
|---|---|---|
| Technology | Next‑Generation Sequencing (NGS) – full gene coverage | Sanger Sequencing of selected exons only |
| Variants Detected | SNVs, indels, copy number variants (CNVs) | Primarily SNVs and small indels |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Quality Accreditation | ISO 9001:2015, DHA‑licensed facility (License No. 1143) | May lack ISO certification |
| Price | 2,800 AED | Varies |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403), notes: “While this NGS test identifies pathogenic FREM2 variants with high precision, its interpretation must always be integrated with a thorough clinical evaluation and family history. A negative result does not exclude Fraser syndrome if the clinical presentation is compelling, as other genes or deep intronic variants may be involved. Please consult your physician before making any medical decision.”
Advisory: Medication Caution
Do not discontinue or adjust any prescribed medication based solely on genetic test results. Always consult your treating physician before making changes to your medication regimen. Genetic findings complement but do not replace clinical judgment.
Exclusion Criteria
- Allogeneic bone marrow/stem cell transplant: Patients who have received a transplant may have donor DNA that confounds results; alternative samples (e.g., skin biopsy) may be required.
- Recent blood transfusion: If a whole blood sample has been collected within 2 weeks of transfusion, inform the laboratory to ensure accurate interpretation.
- Emergency Red Flags (seek immediate medical attention): If the patient develops sudden respiratory distress, cyanosis, or signs of acute renal failure (e.g., markedly reduced urine output), call emergency services immediately.
Patient FAQ & Clinical Guidance
1. What is the FREM2 genetic test for?
This test detects mutations in the FREM2 gene that cause Fraser syndrome, a rare genetic disorder affecting the eyes, fingers, and kidneys. It is used to confirm a clinical diagnosis, guide family planning, and inform multidisciplinary care.
2. Do I need to fast before the test?
No. The test requires a simple whole blood sample (3–5 mL in an EDTA tube) and does not require fasting or special preparation. Samples may also be collected via dried blood spot for infants or difficult venous access.
3. How long do results take?
Results are typically available within 3 to 4 weeks from the date the sample is received at our ISO‑accredited laboratory. The process includes DNA extraction, NGS library preparation, sequencing, bioinformatic analysis, and a comprehensive clinical report signed by a PhD molecular geneticist.
4. Is home collection available for this test?
Yes. Our VIP Mobile Phlebotomy service provides temperature‑controlled cold‑chain home collection daily from 8 AM to 11 PM. A trained phlebotomist will visit your home to collect the sample in accordance with hospital‑grade safety protocols.
5. Can this test be used for prenatal diagnosis?
Yes, when combined with expert genetic counselling, this NGS‑based test can be performed on chorionic villus samples or amniocytes. Prenatal testing requires independent medical consent and should be conducted by an experienced obstetrician. Results must be discussed with a clinical geneticist.
UAE Regulatory & Data Privacy Adherence
Data Protection: All patient data is handled in compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Laboratory Credentials: Our facility holds DHA License No. 1143 and is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). The laboratory is located at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | FREM2 Gene (Fraser Syndrome) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (3–5 mL EDTA), extracted DNA, or dried blood spot |
| Methodology Used | Next‑Generation Sequencing (NGS) – full coding region plus intronic boundaries |
| ICD‑10‑CM Code | Q87.0 |
| LOINC Code | 83325-4 |
| DHA Facility License & Address | DHA License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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