Test Price
2,800 AEDโ Home Collection Available
DHA-CERTIFIED GENOMIC TEST ยท ISO 9001:2015 ยท UAE TRUSTED
FOXC2 Gene Lymphedema-Distichiasis Syndrome Genetic Test in UAE | 2800 AED | DHA-Approved Laboratory
Executive Summary & Core Metrics
This comprehensive genetic test analyses the FOXC2 gene using next-generation sequencing (NGS) for precise detection of lymphedema-distichiasis syndrome. The test delivers 99.9% diagnostic sensitivity, includes copy number variation analysis, and is supported by VIP mobile phlebotomy with cold-chain home collection available daily from 8 AM to 11 PM across the UAE. A free genetic counselling session and post-test telephonic guidance are included.
- โ Accuracy: 99.9% diagnostic sensitivity via ISO 9001:2015 certified processing (Certificate INT/EGQ/2509DA/3139).
- โ Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM โ 11 PM, all UAE).
- โ Clinical Guidance: Telephonic post-test interpretation by a DHA-licensed consultant medical geneticist.
- โ Insurance: Direct billing verification โ send your card via WhatsApp to +971 54 548 8731.
- โ Privacy & Compliance: Data protection adheres to Federal Decree-Law No. 45 of 2021 (PDPL) and Federal Law No. 2 of 2019.
Test Overview & Methodology
The FOXC2 gene NGS test examines all coding exons and flanking splice sites to identify disease-causing mutations responsible for lymphedema-distichiasis syndrome. This rare dysmorphology condition features childhood-onset lymphedema of the lower limbs and double rows of eyelashes (distichiasis). NGS provides higher sensitivity than traditional Sanger sequencing, including copy number variation detection, and is the gold standard for definitive diagnosis and family cascade screening.
| Parameter | Our Test | Closest Alternative |
|---|---|---|
| Precision | GOLD 99.9% diagnostic sensitivity; full coding exons + 20 bp flanking splice sites coverage via NGS with CNV analysis | Sanger sequencing โ limited to point mutations/small indels, may miss large deletions |
| Method | NGS (Next Generation Sequencing) with integrated CNV analysis | Sanger sequencing without CNV detection, lower throughput |
| Turnaround | 3 to 4 Weeks (expedited reporting available) | 4 to 6 Weeks typical |
| Clinical Support | Free genetic counselling + pedigree drafting + post-test telephonic guidance | Often not included |
Physician Insight & Safety Protocols
โThis NGS test provides definitive molecular confirmation of FOXC2-related lymphedema-distichiasis syndrome, enabling clinicians to initiate early surveillance for cardiac, ocular, and lymphatic complications. However, results must always be correlated with full clinical and family history; no genetic report should replace a detailed physical examination and multidisciplinary assessment.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
โ Medication Safety & Exclusion Criteria
Do not discontinue prescribed medication without consulting your doctor.
- Exclusion Criteria: This test is not suitable for standalone fetal diagnosis, preimplantation genetic testing, or asymptomatic minors without a clinical indication. Patients who have received a blood transfusion within the last 2 weeks or have an active severe infection should defer sample collection.
- Emergency Red Flags: If your child develops sudden shortness of breath, severe chest pain, sudden vision loss, or rapidly worsening limb swelling, seek immediate medical attention โ these may indicate complications like pulmonary embolism or acute lymphatic obstruction.
- Sample collection is performed by DHA-licensed phlebotomists using sterile, single-use equipment. Rare adverse events (bruising, fainting) are managed on-site.
Patient FAQ & Clinical Guidance
1. What is the FOXC2 gene test and who should undergo it?
Direct Clinical Answer: This NGS test detects pathogenic FOXC2 variants causing lymphedema-distichiasis syndrome, recommended for children with leg lymphedema and double eyelashes or a positive family history. Adults planning a family or seeking cascade screening for relatives may also benefit.
If your child shows swelling of the lower limbs from infancy or early childhood and an extra row of eyelashes (distichiasis), this test confirms the diagnosis. It requires a prior clinical evaluation and genetic counselling session to draw a family pedigree and assess inheritance pattern.
2. How is the sample collected and what are the pre-test requirements?
Direct Clinical Answer: A simple blood draw is accepted. A genetic counselling session to construct a family pedigree is mandatory before testing. No fasting is required.
Our VIP mobile phlebotomy team visits your home between 8 AM and 11 PM and obtains a venous blood sample using sterile venipuncture. Alternatively, a finger-prick sample on FTA card may be used. You must provide a detailed clinical history and attend a free pre-test video counselling session with a clinical geneticist. Postpone collection if the patient has a fever or has received a blood transfusion within 2 weeks.
3. How accurate is this test and what is the turnaround time?
Direct Clinical Answer: With 99.9% diagnostic sensitivity and complete NGS coverage of all FOXC2 coding exons plus CNV analysis, results are available in 3 to 4 weeks.
The ISO-certified laboratory uses the latest Illumina platform. The report is issued in a DHA-compliant format with clear classification of variants (pathogenic, likely pathogenic, variants of uncertain significance). A post-test telephonic consultation with our genetics team ensures you understand the implications for your childโs care and family planning.
UAE Regulatory & Data Privacy Adherence
Data Protection & Healthcare Compliance
This test is performed under the regulatory framework of the Dubai Health Authority (DHA) and in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data are encrypted, stored securely, and used solely for diagnostic purposes with explicit patient consent.
Clinical & Logistical Metadata
| Test Name | FOXC2 Gene Lymphedema-Distichiasis Syndrome Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks (expedited reporting available on request) |
| Sample Type / Matrix | Whole blood (EDTA) or FTA card โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM โ 11 PM |
| Methodology Used | Next Generation Sequencing (NGS) with copy number variation (CNV) analysis, full coding regions + 20 bp flanking splice sites |
| ICD-10-CM Code | Q87.8 (Other specified congenital malformation syndromes affecting multiple systems); I89.0 (Lymphedema, not elsewhere classified) |
| LOINC Code | 90362-5 (FOXC2 gene mutation detection) |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
Book Your Home Collection or Get Insurance Verification
Schedule your VIP phlebotomy (8 AM โ 11 PM) or send your insurance card for direct billing.
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All reports reviewed by DHA-Certified physicians