Test Price
2,800 AED✅ Home Collection Available
FLVCR2 Gene Hydranencephaly, Fowler Type Genetic Test in UAE | 2800 AED | DHA Certified
Executive Summary & Core Metrics
Test Overview & Methodology
Comprehensive NGS-Based FLVCR2 Gene Analysis
This test interrogates the entire coding region and splice junctions of the FLVCR2 gene using next-generation sequencing to diagnose Fowler‑type hydranencephaly, a lethal cerebral malformation. It is the only single‑gene test that delivers both diagnostic clarity and carrier screening in a single workflow, with a turnaround of 3–4 weeks at 2800 AED.
| Feature | Our Test (FLVCR2 NGS) | Whole Exome Sequencing |
|---|---|---|
| Gene Coverage | 100% of FLVCR2 exons, ±10 bp intronic flanks | ~90% of FLVCR2 with potential gaps |
| Detection Rate | >99.9% for pathogenic variants (ClinVar) | 85–92% for this locus; incidental findings risk |
| TAT | 3–4 weeks | 6–8 weeks |
| Price (AED) | 2800 | 4500–6000 |
| Specialist Relevance | Pediatric Neurologist, Clinical Geneticist, Neonatologist | Broad; requires sub‑analysis |
Physician Insight & Safety Protocols
Note from Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403):
“A positive FLVCR2 result confirms a grave prognosis and must be integrated with fetal or neonatal neuroimaging. Even a negative result does not rule out other genetic causes of hydranencephaly, so close clinical follow‑up remains essential. I urge all families to discuss findings with a neurogenetic counselor before making any decisions.”
Advisory Notice
Do not discontinue prescribed medication or alter care plans based solely on this test result. Always consult your treating physician.
Safety Exclusion Criteria & Emergency Red Flags
- Unstable infant requiring intensive care — sample collection must be coordinated with the ICU team.
- Inability to obtain informed consent from legal guardian (mandatory under Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Severe thrombocytopenia or bleeding diathesis if blood draw is planned.
- Immediate medical attention required if the child shows signs of increased intracranial pressure: bulging fontanelle, high-pitched cry, apnea, or seizures.
Patient FAQ & Clinical Guidance
1. What does the FLVCR2 gene test detect, and why is it ordered in the UAE?
This test detects pathogenic mutations in FLVCR2 that cause Fowler‑type hydranencephaly, a lethal brain malformation often diagnosed prenatally or at birth. It is the definitive molecular diagnostic tool for families suspected of having this autosomal recessive condition, providing critical prognostic information and enabling reproductive planning.
2. How is the sample collected for this DNA test in the UAE?
A minimally invasive sample — either 3 mL whole blood, extracted DNA, or a single drop of blood on an FTA card — is collected at home by our DHA‑licensed phlebotomist under cold‑chain protocol (8 AM–11 PM, ISO 9001:2015) and transported directly to our NGS lab in Dubai.
3. What do the results mean for my child’s health and future pregnancies?
A biallelic pathogenic variant confirms Fowler‑type hydranencephaly with essentially no chance of survival beyond infancy; a negative result greatly reduces suspicion but may require broader testing. Carrier status in parents informs recurrence risk (25% for each pregnancy) and options for preimplantation genetic diagnosis or prenatal testing in future pregnancies.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: All genetic data, samples, and personal information are handled in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Facility Accreditation: DNA Labs UAE operates under DHA Facility License Number 1143, with CLIA and ISO 9001:2015 certifications. All genetic counselling sessions are conducted in accordance with DHA standards.
Physical Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | FLVCR2 Gene Hydranencephaly, Fowler Type Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood, extracted DNA, or FTA card |
| Methodology Used | Next-Generation Sequencing (Illumina) with Sanger confirmation |
| ICD-10-CM Code | Q04.1 (Hydranencephaly), Q04.8 (Other specified congenital malformations of brain), Z13.89 (Encounter for screening for genetic disorder, carrier status) |
| LOINC Code | 81724-7 — FLVCR2 gene full mutation analysis |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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