Test Price
2,800 AED✅ Home Collection Available
DSG1 Gene Sequencing Test for Keratosis Palmoplantaris Striata Type 1 in UAE
Executive Summary & Core Metrics
Integrated Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This NGS‑based test comprehensively analyses the DSG1 gene to definitively confirm striate palmoplantar keratoderma type 1 (SPPK1), enabling dermatologists and clinical geneticists to establish an accurate molecular diagnosis and stratify familial risk.
| Feature | Our Test (DSG1 NGS Sequencing) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next Generation Sequencing (Illumina® platform) – full coding region coverage | Sanger sequencing – limited to known hotspots |
| Analytic Sensitivity | >99.9% | ~99.0% (single nucleotide variants only) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Home Collection & ISO Certification | Included – ISO 9001:2015 Certified | Not available |
Physician Insight & Safety Protocols
As a Consultant Medical Genetics at DNA Labs UAE, I confirm that targeted NGS sequencing of the DSG1 gene provides a precise molecular diagnosis for striate palmoplantar keratoderma type 1 (SPPK1). Accurate variant classification requires rigorous bioinformatic analysis and correlation with clinical phenotype and family pedigree. This test is an essential component of the diagnostic pathway, but results should always be contextualized within a comprehensive dermatological and genetic counselling framework.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Safety & Exclusion Notice
Pre-Genetic Testing Guidance: Genetic testing for SPPK1 confirms a diagnosis but does not replace ongoing clinical dermatological care. Do not modify any prescribed treatments without prior consultation with your healthcare provider.
Pre-Test Exclusion Criteria
- Active systemic infection or febrile illness contraindicating sample collection.
- Known bleeding disorder without prior medical clearance.
- Inability to tolerate a standard peripheral blood draw or provide adequate FTA card sample.
ER Red Flags (Seek Emergency Care)
- Sudden widespread cutaneous blistering, erosions, or signs suggestive of Staphylococcal Scalded Skin Syndrome.
- Secondary infection indicated by fever, purulent discharge, or spreading erythema.
- Any acute systemic deterioration.
Patient FAQ & Clinical Guidance
1. What is the DSG1 Gene Sequencing Test used for?
This NGS test detects pathogenic variants in the DSG1 gene to confirm striate palmoplantar keratoderma type 1 (SPPK1) and guide familial genetic counselling.
2. How is the test performed and what sample is required?
A small peripheral whole blood sample or a single drop of blood on an FTA card is collected by a certified phlebotomist during our temperature-controlled home collection service, available daily from 8 AM to 11 PM.
3. How accurate is the test and what is the turnaround time?
With >99.9% analytic sensitivity and robust NGS chemistry, results are delivered within 3 to 4 weeks from sample receipt at the laboratory.
UAE Regulatory & Data Privacy Adherence
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing, patient consent, and safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Analyses are performed under ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) at DNA Labs UAE, a DHA-licensed facility.
Clinical & Logistical Metadata
| Test Name | DSG1 Gene Sequencing Test for Keratosis Palmoplantaris Striata Type 1 |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral whole blood, serum, plasma, or FTA card (dried blood spot) |
| Methodology Used | Next Generation Sequencing (NGS) on Illumina® Platform |
| ICD-10-CM Code | Q82.8 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License No: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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