Test Price
2,800 AED✅ Home Collection Available
DCX Gene Lissencephaly, X-linked Type 1 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Sequencing Lab (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM – 11 PM) by DHA-licensed phlebotomists.
Clinical Guidance: Telephonic Post‑Test Result Interpretation session with a senior genetic counsellor.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The DCX Gene Lissencephaly, X-linked Type 1 NGS Test employs high-coverage next‑generation sequencing to identify pathogenic variants in the DCX gene, the definitive cause of classic lissencephaly and subcortical band heterotopia. This DHA‑compliant assay combines Illumina NovaSeq 6000 technology with Sanger confirmation, offering unparalleled diagnostic precision for paediatric, neurological, and genetic counselling workflows across the UAE.
| Feature | Our Test (DCX NGS) | Closest Alternative (Single‑Site Sanger) |
|---|---|---|
| Precision | >99.9% analytical sensitivity for all exonic variants | Limited to known familial mutations; 95% for targeted site |
| Method | NGS (Illumina NovaSeq) + Sanger confirmation, >1000× mean depth | Sanger sequencing of single amplicon |
| Turnaround Time | 3–4 weeks | 2–4 weeks |
| Regulatory Approval | ISO 9001:2015, DHA facility licence 1143 | Often lacks ISO certification; limited to single‑lab validation |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasize that accurate molecular diagnosis of DCX‑related lissencephaly is crucial for counselling families about recurrence risks and for guiding early intervention. This NGS test provides comprehensive analysis of the DCX gene, but it is essential to interpret results in the context of clinical and imaging findings. A negative result does not exclude other genetic aetiologies—all findings must be integrated with the child’s neuroimaging and clinical trajectory.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Infants requiring intensive care whose clinical instability precludes safe phlebotomy.
- Exclusion: Inability to obtain blood sample or a DNA FTA card; severe coagulopathy without physician clearance.
- ER Red Flag: New‑onset seizures, persistent vomiting, lethargy, or bulging fontanelle in an infant with suspected lissencephaly — seek immediate emergency care.
- ER Red Flag: Signs of raised intracranial pressure (high-pitched cry, sunsetting eyes) after diagnosis; do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the DCX gene test, and why is it performed?
Answer: The DCX NGS test sequences the entire coding region of the DCX gene to detect pathogenic variants responsible for X‑linked lissencephaly type 1 and subcortical band heterotopia, enabling accurate diagnosis and family‑wide genetic counselling.
This test is ordered when clinical features (agyria/pachygyria on MRI, developmental delay, epilepsy) and family history suggest DCX‑related neuronal migration disorder. It helps distinguish classic lissencephaly from other cortical malformations and guides prognosis and reproductive options.
2. How is the sample collected for this test in the UAE?
Answer: A DHA‑licensed phlebotomist visits your home at a scheduled slot to perform a simple blood draw (3‑5 mL in EDTA tube) or collect a DNA FTA card, followed by ISO‑certified cold‑chain transport to our central laboratory.
All home collections for minors strictly adhere to the UAE’s Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, requiring parental consent and a pediatrician referral. Samples are accepted from 8 AM to 11 PM, seven days a week, with results delivered via secure patient portal.
3. What do the results mean, and what support is available?
Answer: A positive result confirms a pathogenic variant in DCX, providing a definitive aetiology for the brain malformation and guiding early intervention; a negative result rules out DCX‑related lissencephaly but does not exclude other genetic causes, which our team will explain in detail.
All reports include variant classification per ACMG guidelines. A complimentary telephonic post‑test consultation with a certified genetic counsellor is provided. For further genetic evaluation, we can facilitate referral to paediatric neurology or clinical genetics services within UAE healthcare networks, in compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019.
UAE Regulatory & Data Privacy Adherence
- All personal health data processed per Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring encrypted transfer and storage.
- Medical testing and reporting performed under Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, with strict adherence to patient safety and result accuracy standards.
- Clinical safety and patient consent governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 certified facility (Certificate: INT/EGQ/2509DA/3139) – DHA Licence No. 1143.
- Pre‑test genetic counselling session and pedigree chart review strongly recommended to optimise interpretation (available via WhatsApp booking).
Clinical & Logistical Metadata
| Test Name | DCX Gene Lissencephaly, X-linked Type 1 NGS Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA) or DNA FTA card |
| Methodology Used | Next‑Generation Sequencing (Illumina NovaSeq) + Sanger confirmation |
| ICD-10-CM Code | Q04.3 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians