Test Price
2,800 AED✅ Home Collection Available
CUL3 Gene Pseudohypoaldosteronism Type 2E Gordon Syndrome NGS Genetic Test in UAE
Executive Summary & Core Metrics
This diagnostic service delivers definitive molecular analysis of the CUL3 gene via Next-Generation Sequencing (NGS), achieving >99.9% analytical sensitivity for point mutations and small indels. The test confirms or excludes Pseudohypoaldosteronism Type 2E (Gordon syndrome), enabling targeted thiazide therapy and cascade screening for at-risk relatives. Our laboratory holds ISO 9001:2015 certification and operates under DHA Facility License 1143. VIP Mobile Phlebotomy is available daily from 8 AM to 11 PM for peripheral whole blood collection. Direct insurance verification is accessible via WhatsApp at +971 54 548 4837.
Test Overview & Methodology
The assay interrogates all coding exons and flanking intronic regions of the CUL3 gene using paired-end sequencing on an Illumina platform. Bioinformatic analysis aligns reads to GRCh38 and classifies variants per ACMG/AMP 2015 guidelines. The report includes population frequency data, in silico pathogenicity predictions, and clinical correlation with electrolyte and renin-aldosterone profiles.
| Feature | Our CUL3 NGS Test | Closest Alternative |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) with full gene coverage | Targeted Sanger sequencing of known hotspots |
| Analytical Sensitivity | >99.9% for point mutations, small indels | ~99% for pre‑defined regions only |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
| Clinical Reporting | ACMG/AMP variant classification with clinical correlation | Basic variant detection report |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I interpret CUL3 variants strictly within a comprehensive clinical context that includes serum potassium, blood pressure trends, plasma renin activity, and aldosterone levels. Genetic results provide diagnostic clarity but do not replace ongoing clinical assessment. Patients should never alter antihypertensive or potassium-modifying medications without direct supervision from their treating physician.”
Advisory: Medication & Clinical Context
This molecular test is designed for diagnostic clarification and does not mandate immediate therapy changes. Do not discontinue prescribed thiazide diuretics, potassium-lowering resins, or any antihypertensive regimen without a thorough medical review. Genetic findings must be correlated with a complete electrolyte panel, renal function tests, and ambulatory blood pressure monitoring before any treatment adjustment is considered.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Testing is not offered for asymptomatic minors without documented parental or guardian informed consent, nor for individuals lacking a suggestive personal or family history of early‑onset hypertension with hyperkalemia.
- Exclusion: Patients in acute hypertensive crisis, unstable cardiac arrhythmia, or with decompensated renal function should be clinically stabilised before elective genetic testing is scheduled.
- Red Flag: Sudden severe headache, chest pain, palpitations, muscle weakness, or paralysis may indicate a hyperkalemic emergency or hypertensive urgency. Seek immediate emergency medical care.
Patient FAQ & Clinical Guidance
1. What does a positive CUL3 genetic result mean for my treatment?
A positive result identifies a pathogenic variant in the CUL3 gene, confirming the diagnosis of Pseudohypoaldosteronism Type 2E. This enables your physician to initiate or optimise thiazide diuretic therapy, which specifically corrects the underlying electrolyte and blood pressure abnormalities. It also permits early cascade testing of first‑degree relatives who may be at risk.
2. How is the sample collected and what is the turnaround time?
A peripheral whole blood sample is collected in an EDTA tube. You may visit our Dubai Healthcare City laboratory or request VIP Mobile Phlebotomy at your home between 8 AM and 11 PM daily. Results are reported within 3 to 4 weeks, accompanied by a telephonic consultation to discuss clinical implications with a qualified genetic specialist.
3. Does my health insurance cover this genetic test?
Many UAE health insurers provide coverage for medically indicated genetic testing. Forward your insurance card via WhatsApp to +971 54 548 4837, and our team will perform a real‑time benefits verification prior to sample collection. Direct billing arrangements are available with major networks.
4. Can this test be performed on children or other family members?
Yes, testing of minors requires written informed consent from a parent or legal guardian. Cascade screening of asymptomatic adult relatives is strongly recommended when a proband tests positive, as early detection can prevent hypertensive and hyperkalemic complications through timely intervention.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework: All genetic data handling complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures follow Federal Decree‑Law No. 4 of 2016 on Medical Liability. The laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and holds DHA Facility License 1143. Genetic testing of minors is performed only with explicit guardian consent.
Clinical & Logistical Metadata
| Test Name | CUL3 Gene Pseudohypoaldosteronism Type 2E (Gordon Syndrome) NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (21–28 Business Days) |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA Tube) |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage, Illumina Platform |
| ICD-10-CM Code | E26.89 |
| LOINC Code | 90270-6 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians