Test Price
2,800 AED✅ Home Collection Available
CRB2 Gene (Ventriculomegaly–Cystic Kidney Disease) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Diagnostic Accuracy & Service Framework
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Next-Generation Sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a Consultant Medical Genetics specialist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The CRB2 NGS test analyzes the entire coding region of the CRB2 gene for pathogenic variants associated with autosomal recessive ventriculomegaly–cystic kidney disease syndrome. High-throughput sequencing detects single nucleotide variants, small insertions and deletions, and provides copy number variation clues across all coding exons and flanking splice sites. This definitive molecular diagnostic approach supports accurate prognosis, reproductive planning, and coordinated care between nephrology and neurology specialists.
| Feature | Our Test (NGS) | Alternative (Sanger) |
|---|---|---|
| Technology | Next-Generation Sequencing | Single-gene Sanger Sequencing |
| Coverage | Full coding exons ±20 bp splice sites | Limited to targeted exons only |
| Variant Detection | SNVs, indels, CNV clues, novel variants | Known point mutations |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Price | 2,800 AED | 1,500–2,000 AED (limited scope) |
Physician Insight & Safety Protocols
“The CRB2 gene test provides a molecular anchor for families navigating ventriculomegaly and cystic kidney disease. However, genetic results must be interpreted alongside prenatal imaging, renal ultrasound, and a detailed three-generation pedigree. A negative result does not exclude all genetic etiologies, and variant reclassification may occur over time. Please discuss all findings with a board-certified clinical geneticist to ensure comprehensive care planning.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory on Clinical Management
⚠️ Medication & Clinical Caution
This genetic test provides diagnostic information and must not replace ongoing clinical care. Do not discontinue, alter, or initiate any prescribed medication or therapy without consulting your treating physician. Genetic findings require correlation with imaging, laboratory, and clinical data for accurate interpretation.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inadequate sample (hemolyzed blood, degraded DNA) or known mosaicism requiring tissue-based analysis. Patients with acute metabolic crisis or unstable vital signs should defer genetic sampling until clinically stable.
- Emergency Red Flags: New-onset seizures, acute loss of consciousness, rapidly rising blood pressure, signs of acute kidney injury (oliguria, edema, anuria) — seek emergency care immediately. Genetic testing is not intended for acute diagnostic decision-making.
- Informed Consent: A mandatory genetic counselling session is required before sample collection to document informed consent and pedigree, in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the CRB2 gene ventriculomegaly with cystic kidney disease NGS test?
This test uses Next-Generation Sequencing to analyze the entire CRB2 gene for mutations causing ventriculomegaly and cystic kidney disease. It provides a definitive molecular diagnosis for patients with prenatal ultrasound findings of cerebral ventriculomegaly and renal cysts, or for at-risk family screening. Results aid in prognosis, reproductive planning, and coordinated care between nephrology and neurology teams.
2. How should I prepare for the test?
A blood sample or extracted DNA is required along with a mandatory genetic counselling session to document a detailed family pedigree. Fasting is not needed; if using an FTA card, a single drop of blood is sufficient. Our VIP Mobile Phlebotomy team provides all collection materials and transports specimens under temperature-controlled cold-chain logistics.
3. What is the turnaround time and how do I get results?
Turnaround time is 3–4 weeks from sample receipt. Results are reviewed and interpreted by a Consultant Medical Genetics, then delivered electronically and by phone. A telephonic post-test counselling session is included to explain findings, clinical implications, and recommended next steps.
4. Is this test covered by insurance in the UAE?
We offer direct billing verification to check your insurance plan’s coverage for medically indicated genetic testing. Many UAE insurers now include hereditary disease panels under their benefits. Send your policy details via WhatsApp at +971 54 548 8731 for pre-authorization assistance.
UAE Regulatory & Data Privacy Adherence
🔒 Legal & Compliance Framework
- Data Protection: All genetic data is processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Governance: Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for secure electronic health records and telemedicine.
- Medical Liability & Consent: Informed consent and clinical safety protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Quality Certification: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) ensuring rigorous quality management across all laboratory processes.
Clinical & Logistical Metadata
| Test Name | CRB2 Gene (Ventriculomegaly–Cystic Kidney Disease) NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) or extracted genomic DNA; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – full coding exons ±20 bp splice sites |
| ICD-10-CM Code | Q04.8, Q61.9 |
| LOINC Code | 81247-9 |
| DHA Facility License & Lab Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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